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Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.
Lipsman N, Meng Y, Bethune AJ, Huang Y, Lam B, Masellis M, Herrmann N, Heyn C, Aubert I, Boutet A, Smith GS, Hynynen K, Black SE. Lipsman N, et al. Nat Commun. 2018 Jul 25;9(1):2336. doi: 10.1038/s41467-018-04529-6. Nat Commun. 2018. PMID: 30046032 Free PMC article. Clinical Trial.
Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior.
Burgess A, Dubey S, Yeung S, Hough O, Eterman N, Aubert I, Hynynen K. Burgess A, et al. Radiology. 2014 Dec;273(3):736-45. doi: 10.1148/radiol.14140245. Epub 2014 Sep 15. Radiology. 2014. PMID: 25222068 Free PMC article.
Focused ultrasound-mediated drug delivery through the blood-brain barrier.
Burgess A, Shah K, Hough O, Hynynen K. Burgess A, et al. Expert Rev Neurother. 2015 May;15(5):477-91. doi: 10.1586/14737175.2015.1028369. Expert Rev Neurother. 2015. PMID: 25936845 Free PMC article. Review.
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma.
Treat LH, McDannold N, Zhang Y, Vykhodtseva N, Hynynen K. Treat LH, et al. Ultrasound Med Biol. 2012 Oct;38(10):1716-25. doi: 10.1016/j.ultrasmedbio.2012.04.015. Epub 2012 Jul 19. Ultrasound Med Biol. 2012. PMID: 22818878 Free PMC article.
Ultrasound for drug and gene delivery to the brain.
Hynynen K. Hynynen K. Adv Drug Deliv Rev. 2008 Jun 30;60(10):1209-17. doi: 10.1016/j.addr.2008.03.010. Epub 2008 Apr 6. Adv Drug Deliv Rev. 2008. PMID: 18486271 Free PMC article. Review.
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