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Interactions of oxysterols with membranes and proteins.
Olkkonen VM, Hynynen R. Olkkonen VM, et al. Among authors: hynynen r. Mol Aspects Med. 2009 Jun;30(3):123-33. doi: 10.1016/j.mam.2009.02.004. Epub 2009 Feb 25. Mol Aspects Med. 2009. PMID: 19248802 Review.
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.
Hynynen R, Suchanek M, Spandl J, Bäck N, Thiele C, Olkkonen VM. Hynynen R, et al. J Lipid Res. 2009 Jul;50(7):1305-15. doi: 10.1194/jlr.M800661-JLR200. Epub 2009 Feb 17. J Lipid Res. 2009. PMID: 19224871 Free PMC article.
Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis.
Hynynen R, Laitinen S, Käkelä R, Tanhuanpää K, Lusa S, Ehnholm C, Somerharju P, Ikonen E, Olkkonen VM. Hynynen R, et al. Biochem J. 2005 Aug 15;390(Pt 1):273-83. doi: 10.1042/BJ20042082. Biochem J. 2005. PMID: 15859942 Free PMC article.
Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants.
Lehto M, Hynynen R, Karjalainen K, Kuismanen E, Hyvärinen K, Olkkonen VM. Lehto M, et al. Among authors: hynynen r. Exp Cell Res. 2005 Nov 1;310(2):445-62. doi: 10.1016/j.yexcr.2005.08.003. Epub 2005 Sep 6. Exp Cell Res. 2005. PMID: 16143324
The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?
Olkkonen VM, Johansson M, Suchanek M, Yan D, Hynynen R, Ehnholm C, Jauhiainen M, Thiele C, Lehto M. Olkkonen VM, et al. Among authors: hynynen r. Biochem Soc Trans. 2006 Jun;34(Pt 3):389-91. doi: 10.1042/BST0340389. Biochem Soc Trans. 2006. PMID: 16709169 Review.
Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.
Mattila J, Havula E, Suominen E, Teesalu M, Surakka I, Hynynen R, Kilpinen H, Väänänen J, Hovatta I, Käkelä R, Ripatti S, Sandmann T, Hietakangas V. Mattila J, et al. Among authors: hynynen r. Cell Rep. 2015 Oct 13;13(2):350-64. doi: 10.1016/j.celrep.2015.08.081. Epub 2015 Oct 1. Cell Rep. 2015. PMID: 26440885 Free article.
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
Suchanek M, Hynynen R, Wohlfahrt G, Lehto M, Johansson M, Saarinen H, Radzikowska A, Thiele C, Olkkonen VM. Suchanek M, et al. Among authors: hynynen r. Biochem J. 2007 Aug 1;405(3):473-80. doi: 10.1042/BJ20070176. Biochem J. 2007. PMID: 17428193 Free PMC article.