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3,834 results

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St. John's wort (Hypericum perforatum) and depression: what happens to the neurotransmitter systems?
Kholghi G, Arjmandi-Rad S, Zarrindast MR, Vaseghi S. Kholghi G, et al. Naunyn Schmiedebergs Arch Pharmacol. 2022 Jun;395(6):629-642. doi: 10.1007/s00210-022-02229-z. Epub 2022 Mar 16. Naunyn Schmiedebergs Arch Pharmacol. 2022. PMID: 35294606 Review.
St. John's wort (Hypericum perforatum) is a herbaceous plant containing many bioactive molecules including naphthodianthrones, phloroglucinol derivatives, flavonoids, bioflavonoids, proanthocyanidins, and chlorogenic acid. ...
St. John's wort (Hypericum perforatum) is a herbaceous plant containing many bioactive molecules including naphthodianthrones, …
Hypericum perforatum L. attenuates depression by regulating Akkermansia muciniphila, tryptophan metabolism and NFkappaB-NLRP2-Caspase1-IL1beta pathway.
Jiang ZM, Wang FF, Zhao YY, Lu LF, Jiang XY, Huang TQ, Lin Y, Guo L, Weng ZB, Liu EH. Jiang ZM, et al. Phytomedicine. 2024 Sep;132:155847. doi: 10.1016/j.phymed.2024.155847. Epub 2024 Jul 3. Phytomedicine. 2024. PMID: 38996505
BACKGROUND: Gut microbiota dysbiosis significantly contributes to progression of depression. Hypericum perforatum L. (HPL) is traditionally used in Europe for treating depression. However, its mechanism remains largely underexplored. ...
BACKGROUND: Gut microbiota dysbiosis significantly contributes to progression of depression. Hypericum perforatum L. (HPL) is …
Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy.
Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J. Ma X, et al. Int J Nanomedicine. 2025 Feb 4;20:1529-1541. doi: 10.2147/IJN.S510339. eCollection 2025. Int J Nanomedicine. 2025. PMID: 39925681 Free PMC article.
Plant-derived exosome-like nanovesicles offer an innovative platform for enhancing photosensitizer performance. METHODS: Hypericum perforatum-derived nanovesicles (HPDENs) were characterized using electron microscopy, dynamic light scattering, and proteomic and miRN …
Plant-derived exosome-like nanovesicles offer an innovative platform for enhancing photosensitizer performance. METHODS: Hypericum …
Hypericum perforatum: a comprehensive review on pharmacognosy, preclinical studies, putative molecular mechanism, and clinical studies in neurodegenerative diseases.
Suryawanshi MV, Gujarathi PP, Mulla T, Bagban I. Suryawanshi MV, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):3803-3818. doi: 10.1007/s00210-023-02915-6. Epub 2024 Jan 4. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38175276 Review.
The herb Hypericum perforatum, also referred to as St. John's wort, has drawn a lot of interest because of its potential therapeutic benefits in treating neurodegenerative illnesses. ...In conclusion, Hypericum perforatum shows tremendous promise as a …
The herb Hypericum perforatum, also referred to as St. John's wort, has drawn a lot of interest because of its potential thera …
Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action.
Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. Zirak N, et al. J Cell Physiol. 2019 Jun;234(6):8496-8508. doi: 10.1002/jcp.27781. Epub 2018 Nov 21. J Cell Physiol. 2019. PMID: 30461013 Review.
Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adverse effects. Hypericum perforatum, widely known as St. John's wort, is a perennial herbaceous plant most well known for its ant …
Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adver …
Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis.
Ben-Eliezer D, Yechiam E. Ben-Eliezer D, et al. Sci Rep. 2016 Oct 20;6:35700. doi: 10.1038/srep35700. Sci Rep. 2016. PMID: 27762349 Free PMC article. Review.
Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competitive synergistic manner, and may have nootropic potential. ...Thus, while primarily considered as a medication for depression, H. perforat …
Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competit …
Hypericum perforatum L. preparations for menopause: a meta-analysis of efficacy and safety.
Liu YR, Jiang YL, Huang RQ, Yang JY, Xiao BK, Dong JX. Liu YR, et al. Climacteric. 2014 Aug;17(4):325-35. doi: 10.3109/13697137.2013.861814. Epub 2013 Dec 27. Climacteric. 2014. PMID: 24188229
OBJECTIVE: To compare by meta-analysis the efficacy and adverse events of Hypericum perforatum L. (St. John's Wort), or its combinations, and placebo for menopausal women. ...CONCLUSION: Extracts of Hypericum perforatum L. have possibly fewer side-effe …
OBJECTIVE: To compare by meta-analysis the efficacy and adverse events of Hypericum perforatum L. (St. John's Wort), or its co …
Hypericum perforatum (St John's wort) beyond depression: A therapeutic perspective for pain conditions.
Galeotti N. Galeotti N. J Ethnopharmacol. 2017 Mar 22;200:136-146. doi: 10.1016/j.jep.2017.02.016. Epub 2017 Feb 12. J Ethnopharmacol. 2017. PMID: 28216196 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum perforatum L. (Hypericaceae), popularly called St. John's wort (SJW), has a rich historical background being one of the oldest used and most extensively investigated medicinal herbs. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum perforatum L. (Hypericaceae), popularly called St. John's wort (SJW), has a rich his …
Quality control of Hypericum perforatum L. analytical challenges and recent progress.
Agapouda A, Booker A, Kiss T, Hohmann J, Heinrich M, Csupor D. Agapouda A, et al. J Pharm Pharmacol. 2019 Jan;71(1):15-37. doi: 10.1111/jphp.12711. Epub 2017 Mar 7. J Pharm Pharmacol. 2019. PMID: 28266019 Review.
OBJECTIVES: The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum extracts will be reviewed, including routine analytical tools and most modern approaches. KEY FINDINGS: Biologically active components …
OBJECTIVES: The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum …
Monograph. Hypericum perforatum.
[No authors listed] [No authors listed] Altern Med Rev. 2004 Sep;9(3):318-25. Altern Med Rev. 2004. PMID: 15387723 Review. No abstract available.
3,834 results