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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1931 1
1950 1
1951 2
1954 2
1955 3
1957 1
1959 1
1960 1
1964 4
1965 1
1968 2
1969 3
1971 1
1972 1
1973 2
1975 1
1977 2
1980 1
1981 3
1982 1
1984 1
1985 2
1986 4
1987 5
1988 3
1989 5
1990 3
1991 6
1992 7
1993 4
1994 20
1995 10
1996 9
1997 32
1998 45
1999 77
2000 168
2001 192
2002 161
2003 145
2004 160
2005 156
2006 146
2007 129
2008 138
2009 142
2010 143
2011 154
2012 143
2013 139
2014 139
2015 123
2016 140
2017 123
2018 136
2019 149
2020 146
2021 131
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3,137 results
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Page 1
Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action.
Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. Zirak N, et al. J Cell Physiol. 2019 Jun;234(6):8496-8508. doi: 10.1002/jcp.27781. Epub 2018 Nov 21. J Cell Physiol. 2019. PMID: 30461013 Review.
Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adverse effects. Hypericum perforatum, widely known as St. John's wort, is a perennial herbaceous plant most well known for its ant …
Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adver …
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
Russo E, Scicchitano F, Whalley BJ, Mazzitello C, Ciriaco M, Esposito S, Patanè M, Upton R, Pugliese M, Chimirri S, Mammì M, Palleria C, De Sarro G. Russo E, et al. Phytother Res. 2014 May;28(5):643-55. doi: 10.1002/ptr.5050. Epub 2013 Jul 30. Phytother Res. 2014. PMID: 23897801 Review.
Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest used and most extensively investigated medicinal herbs. ...
Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest used and most extensively investigated m
The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial.
Eatemadnia A, Ansari S, Abedi P, Najar S. Eatemadnia A, et al. Complement Ther Med. 2019 Aug;45:109-113. doi: 10.1016/j.ctim.2019.05.028. Epub 2019 May 31. Complement Ther Med. 2019. PMID: 31331546 Clinical Trial.
OBJECTIVES: Hypericum perforatum (St John's wort) is an herbal plant that has antidepressant activity and contains ingredients such as flavonols derivatives, bioflavonoids, proanthocyanidins, xanthones, phloroglucinol, and naphthodianthrones. This study was aimed to …
OBJECTIVES: Hypericum perforatum (St John's wort) is an herbal plant that has antidepressant activity and contains ingredients …
Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations.
Borrelli F, Izzo AA. Borrelli F, et al. AAPS J. 2009 Dec;11(4):710-27. doi: 10.1208/s12248-009-9146-8. Epub 2009 Oct 27. AAPS J. 2009. PMID: 19859815 Free PMC article. Review.
St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically active ingredients, including naphthodianthrones (e.g., hypericin and its derivatives), phloroglucinols derivatives (e.g., hyperforin, which inh …
St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically acti …
Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis.
Ben-Eliezer D, Yechiam E. Ben-Eliezer D, et al. Sci Rep. 2016 Oct 20;6:35700. doi: 10.1038/srep35700. Sci Rep. 2016. PMID: 27762349 Free PMC article. Review.
Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competitive synergistic manner, and may have nootropic potential. ...Thus, while primarily considered as a medication for depression, H. perforat
Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competit …
Monograph. Hypericum perforatum.
[No authors listed] [No authors listed] Altern Med Rev. 2004 Sep;9(3):318-25. Altern Med Rev. 2004. PMID: 15387723 Free article. Review. No abstract available.
Quality control of Hypericum perforatum L. analytical challenges and recent progress.
Agapouda A, Booker A, Kiss T, Hohmann J, Heinrich M, Csupor D. Agapouda A, et al. J Pharm Pharmacol. 2019 Jan;71(1):15-37. doi: 10.1111/jphp.12711. Epub 2017 Mar 7. J Pharm Pharmacol. 2019. PMID: 28266019 Review.
OBJECTIVES: The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum extracts will be reviewed, including routine analytical tools and most modern approaches. KEY FINDINGS: Biologically active components …
OBJECTIVES: The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum
Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract.
Di Pierro F, Risso P, Settembre R. Di Pierro F, et al. Panminerva Med. 2018 Dec;60(4):156-160. doi: 10.23736/S0031-0808.18.03518-8. Epub 2018 Jul 10. Panminerva Med. 2018. PMID: 29991209 Free article. Clinical Trial.
BACKGROUND: Hypericum perforatum is used as medicinal plant for mild to moderately severe depression. ...Aim is to test if greater chemical complexity could result in a greater hypericum antidepressant action. METHODS: A retrospective, 12-month, open-label, o …
BACKGROUND: Hypericum perforatum is used as medicinal plant for mild to moderately severe depression. ...Aim is to test if gre …
[Chemical constituents of Hypericum perforatum].
Shi MJ, Hu JW, Wang JJ, Zhen B, Wang X, Ji TF. Shi MJ, et al. Zhongguo Zhong Yao Za Zhi. 2018 Jul;43(13):2726-2731. doi: 10.19540/j.cnki.cjcmm.20180316.001. Zhongguo Zhong Yao Za Zhi. 2018. PMID: 30111023 Chinese.
A chemical investigation on the aerial parts of Hypericum perforatum resulted in the isolation of a new phloroglucinol derivatives (1), and seven known compounds (2-8). ...Compound 1 was a new compound, and compounds 3-5 were obtained from H. perforatum for t …
A chemical investigation on the aerial parts of Hypericum perforatum resulted in the isolation of a new phloroglucinol derivat …
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