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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 4
1964 5
1965 5
1966 5
1967 3
1968 8
1969 7
1970 13
1971 13
1972 16
1973 17
1974 11
1975 15
1976 17
1977 13
1978 8
1979 17
1980 24
1981 24
1982 25
1983 28
1984 47
1985 47
1986 29
1987 31
1988 52
1989 60
1990 105
1991 137
1992 180
1993 158
1994 186
1995 201
1996 238
1997 239
1998 279
1999 302
2000 390
2001 372
2002 515
2003 584
2004 742
2005 872
2006 1107
2007 957
2008 1007
2009 903
2010 962
2011 1044
2012 947
2013 1058
2014 1012
2015 928
2016 1030
2017 960
2018 812
2019 768
2020 845
2021 896
2022 859
2023 718
2024 261

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21,246 results

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Page 1
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
Jia G, DeMarco VG, Sowers JR. Jia G, et al. Nat Rev Endocrinol. 2016 Mar;12(3):144-53. doi: 10.1038/nrendo.2015.216. Epub 2015 Dec 18. Nat Rev Endocrinol. 2016. PMID: 26678809 Free PMC article. Review.
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote the development of a specific form of cardiomyopathy that is independent of coronary artery disease and hypertension. ...
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote the development of a specific form of cardi …
Hyperinsulinemia in Obesity, Inflammation, and Cancer.
Zhang AMY, Wellberg EA, Kopp JL, Johnson JD. Zhang AMY, et al. Diabetes Metab J. 2021 May;45(3):285-311. doi: 10.4093/dmj.2020.0250. Epub 2021 Mar 29. Diabetes Metab J. 2021. PMID: 33775061 Free PMC article. Review.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are beginning to elucidate the cause-effect relationships between hyperinsulinemia and numerous consequences …
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperi
Exercise and Polycystic Ovary Syndrome.
Woodward A, Klonizakis M, Broom D. Woodward A, et al. Adv Exp Med Biol. 2020;1228:123-136. doi: 10.1007/978-981-15-1792-1_8. Adv Exp Med Biol. 2020. PMID: 32342454 Review.
The mechanism by which exercise improves many CVD risk factors is again associated with improved insulin sensitivity and decreased hyperinsulinemia. In addition to cardiometabolic and reproductive complications, PCOS has been associated with an increased prevalence of ment …
The mechanism by which exercise improves many CVD risk factors is again associated with improved insulin sensitivity and decreased hyperi
Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer.
Janssen JAMJL. Janssen JAMJL. Int J Mol Sci. 2021 Jul 21;22(15):7797. doi: 10.3390/ijms22157797. Int J Mol Sci. 2021. PMID: 34360563 Free PMC article. Review.
For many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest a reverse order and place hyperinsulinemia mechanistically upstream of insulin resistance. ...Drugs that reduce insulin (hyper) secr …
For many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest …
Congenital Hyperinsulinism: Diagnosis and Treatment Update.
Demirbilek H, Hussain K. Demirbilek H, et al. J Clin Res Pediatr Endocrinol. 2017 Dec 30;9(Suppl 2):69-87. doi: 10.4274/jcrpe.2017.S007. Epub 2017 Dec 27. J Clin Res Pediatr Endocrinol. 2017. PMID: 29280746 Free PMC article. Review.
Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited.
da Silva AA, do Carmo JM, Li X, Wang Z, Mouton AJ, Hall JE. da Silva AA, et al. Can J Cardiol. 2020 May;36(5):671-682. doi: 10.1016/j.cjca.2020.02.066. Epub 2020 Feb 12. Can J Cardiol. 2020. PMID: 32389340 Free PMC article. Review.
Support for this concept initially came from clinical and population studies showing correlations among hyperinsulinemia, insulin resistance, and elevated BP in individuals with metabolic syndrome. ...Multiple studies in humans and experimental animals have also shown that …
Support for this concept initially came from clinical and population studies showing correlations among hyperinsulinemia, insulin res …
Increased cell senescence in human metabolic disorders.
Spinelli R, Baboota RK, Gogg S, Beguinot F, Blüher M, Nerstedt A, Smith U. Spinelli R, et al. J Clin Invest. 2023 Jun 15;133(12):e169922. doi: 10.1172/JCI169922. J Clin Invest. 2023. PMID: 37317964 Free PMC article. Review.
Senescent tissues are characterized by dysfunctional cells and increased inflammation, and both progenitor cells and mature, fully differentiated and nonproliferating cells are afflicted. Recent studies have shown that hyperinsulinemia and associated insulin resistance (IR …
Senescent tissues are characterized by dysfunctional cells and increased inflammation, and both progenitor cells and mature, fully different …
Insulin: too much of a good thing is bad.
Kolb H, Kempf K, Röhling M, Martin S. Kolb H, et al. BMC Med. 2020 Aug 21;18(1):224. doi: 10.1186/s12916-020-01688-6. BMC Med. 2020. PMID: 32819363 Free PMC article. Review.
Because of the largely unrestricted insulin signaling, hyperinsulinemia increases the risk of obesity, type 2 diabetes, and cardiovascular disease and decreases health span and life expectancy. ...CONCLUSIONS: The detrimental actions of prolonged high insulin concentration …
Because of the largely unrestricted insulin signaling, hyperinsulinemia increases the risk of obesity, type 2 diabetes, and cardiovas …
Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment.
Zhao H, Zhang J, Cheng X, Nie X, He B. Zhao H, et al. J Ovarian Res. 2023 Jan 11;16(1):9. doi: 10.1186/s13048-022-01091-0. J Ovarian Res. 2023. PMID: 36631836 Free PMC article. Review.
PCOS involves various pathophysiological factors, and affected women usually have significant insulin resistance (IR), which is a major cause of PCOS. IR and compensatory hyperinsulinaemia have differing pathogeneses in various tissues, and IR varies among different PCOS p …
PCOS involves various pathophysiological factors, and affected women usually have significant insulin resistance (IR), which is a major caus …
New Insight into Diabetes Management: From Glycemic Index to Dietary Insulin Index.
Yari Z, Behrouz V, Zand H, Pourvali K. Yari Z, et al. Curr Diabetes Rev. 2020;16(4):293-300. doi: 10.2174/1573399815666190614122626. Curr Diabetes Rev. 2020. PMID: 31203801 Review.
This may be due to focusing on reducing hyperglycemia and neglecting the importance of hyperinsulinemia; while insulin resistance and resultant hyperinsulinemia preceded diabetes onset and may contribute to disease pathogenesis. ...
This may be due to focusing on reducing hyperglycemia and neglecting the importance of hyperinsulinemia; while insulin resistance and …
21,246 results
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