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The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.
Kharade SV, Nichols C, Denton JS. Kharade SV, et al. Future Med Chem. 2016 May;8(7):789-802. doi: 10.4155/fmc-2016-0005. Epub 2016 May 10. Future Med Chem. 2016. PMID: 27161588 Free PMC article. Review.
Small-molecule inhibitors (e.g., sulfonylurea drugs) or activators (e.g., diazoxide) acting on SUR1 or SUR2 have been used clinically for decades to manage the inappropriate secretion of insulin in patients with Type 2 diabetes, hyperinsulinism and intractable hypertension …
Small-molecule inhibitors (e.g., sulfonylurea drugs) or activators (e.g., diazoxide) acting on SUR1 or SUR2 have been used clinically for de …
[A new type of ATP-sensitive potassium channelopathy : Cantu syndrome].
Hiraki Y, Takanari H. Hiraki Y, et al. No To Hattatsu. 2016 Sep;48(5):325-31. No To Hattatsu. 2016. PMID: 30010274 Review. Japanese.
These diseases are referred to as KATP channelopathies. Recently, Cantu syndrome (CS), which was found to be caused by mutations in the ABCC9 or KCNJ8 gene, was newly added to the list of KATP channelopathies. ...
These diseases are referred to as KATP channelopathies. Recently, Cantu syndrome (CS), which was found to be caused by mutatio …