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Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.
Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J, Zhu Y, Chen Q, Wu S. Ma B, et al. Nat Cell Biol. 2015 Jan;17(1):95-103. doi: 10.1038/ncb3073. Epub 2014 Dec 1. Nat Cell Biol. 2015. PMID: 25438054
Here we elucidate a molecular mechanism by which hypoxia deactivates Hippo signalling. We demonstrate that the E3 ubiquitin ligase SIAH2 stimulates YAP by destabilizing LATS2, a critical component of the Hippo pathway, in re …
Here we elucidate a molecular mechanism by which hypoxia deactivates Hippo signalling. We demonstrate that the E3
Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-beta signalling pathways.
Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, Chen Q, Zhu Y. Ma B, et al. Nat Commun. 2016 Mar 31;7:11123. doi: 10.1038/ncomms11123. Nat Commun. 2016. PMID: 27030211 Free PMC article.
Upstream signals of the Hippo pathway have been widely studied, but how microenvironmental factors coordinately regulate this pathway remains unclear. ...We show that Zyxin is required for TGF-beta and hypoxia-induced Lats2 downregulation and deactivat …
Upstream signals of the Hippo pathway have been widely studied, but how microenvironmental factors coordinately regulate