Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.
Nat Cell Biol. 2015.
PMID: 25438054
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Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.
Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J, Zhu Y, Chen Q, Wu S.
Ma B, et al.
Nat Cell Biol. 2015 Jan;17(1):95-103. doi: 10.1038/ncb3073. Epub 2014 Dec 1.
Nat Cell Biol. 2015.
PMID: 25438054
We demonstrate that the E3 ubiquitin ligase SIAH2 stimulates YAP by destabilizing LATS2, a critical component of the Hippo pathway, in response to hypoxia. ...Our data uncover oxygen availability as a microenvironment signal for th …
We demonstrate that the E3 ubiquitin ligase SIAH2 stimulates YAP by destabilizing LATS2, a critical component of …
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Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-beta signalling pathways.
Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, Chen Q, Zhu Y.
Ma B, et al.
Nat Commun. 2016 Mar 31;7:11123. doi: 10.1038/ncomms11123.
Nat Commun. 2016.
PMID: 27030211
Free PMC article.
Upstream signals of the Hippo pathway have been widely studied, but how microenvironmental factors coordinately regulate this pathway remains unclear. ...This interaction facilitates Lats2 ubiquitination and degradation, Yap dephosphorylation and subse …
Upstream signals of the Hippo pathway have been widely studied, but how microenvironmental factors coordinately regulate …
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