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Subpial delivery of adeno-associated virus 9-synapsin-caveolin-1 (AAV9-SynCav1) preserves motor neuron and neuromuscular junction morphology, motor function, delays disease onset, and extends survival in hSOD1G93A mice.
Wang S, Ichinomiya T, Savchenko P, Wang D, Sawada A, Li X, Duong T, Li W, Bonds JA, Kim EJ, Miyanohara A, Roth DM, Patel HH, Patel PM, Tadokoro T, Marsala M, Head BP. Wang S, et al. Theranostics. 2022 Jul 11;12(12):5389-5403. doi: 10.7150/thno.72614. eCollection 2022. Theranostics. 2022. PMID: 35910808 Free PMC article.