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Page 1
Indoleamine 2,3-dioxygenase (IDO)-activity in Severe Psychiatric Disorders: A Systemic Review.
Fellendorf FT, Bonkat N, Dalkner N, Schönthaler EMD, Manchia M, Fuchs D, Reininghaus EZ. Fellendorf FT, et al. Curr Top Med Chem. 2022;22(25):2107-2118. doi: 10.2174/1568026622666220718155616. Curr Top Med Chem. 2022. PMID: 35850653
BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) activity is induced by cellular immune activation and therefore associated with inflammatory diseases, among others psychiatric disorders. ...There are only two studies comparing KYN/TRP in major depress …
BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) activity is induced by cellular immune activation and therefore associate …
Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice.
Walker AK, Wing EE, Banks WA, Dantzer R. Walker AK, et al. Mol Psychiatry. 2019 Oct;24(10):1523-1532. doi: 10.1038/s41380-018-0076-7. Epub 2018 Jul 9. Mol Psychiatry. 2019. PMID: 29988087 Free PMC article.
Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynurenine. ...These findings demonstrate that leucine has antidepressant properties vis-a-vis inflammation-induced depression and one mechanism fo …
Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynurenine. ...These …
Inflammation-induced activation of the indoleamine 2,3-dioxygenase pathway: Relevance to cancer-related fatigue.
Kim S, Miller BJ, Stefanek ME, Miller AH. Kim S, et al. Cancer. 2015 Jul 1;121(13):2129-36. doi: 10.1002/cncr.29302. Epub 2015 Feb 27. Cancer. 2015. PMID: 25728366 Free article. Review.
Although the specific mechanisms remain poorly understood, inflammation is now considered to be a distinct component of CRF in addition to effects of depression, anxiety, insomnia, and other factors. One key biological pathway that may link inflammation and C …
Although the specific mechanisms remain poorly understood, inflammation is now considered to be a distinct component of CRF in additi …
Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.
Barreto FS, Chaves Filho AJM, de Araújo MCCR, de Moraes MO, de Moraes MEA, Maes M, de Lucena DF, Macedo DS. Barreto FS, et al. Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):165-180. doi: 10.1097/FBP.0000000000000384. Behav Pharmacol. 2018. PMID: 29543650 Review.
Similarly, cancers present elevated levels of TNF-alpha, reduced major histocompatibility complex class I and II, and natural killer cells. Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of the tryptophan catabolite (TRYCAT) pathway, is induced b …
Similarly, cancers present elevated levels of TNF-alpha, reduced major histocompatibility complex class I and II, and natural killer cells. …
The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression.
Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R. Maes M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):702-21. doi: 10.1016/j.pnpbp.2010.12.017. Epub 2010 Dec 23. Prog Neuropsychopharmacol Biol Psychiatry. 2011. PMID: 21185346 Review.
This paper reviews the body of evidence that not only tryptophan and consequent 5-HT depletion, but also induction of indoleamine 2,3-dioxygenase (IDO) and the detrimental effects of tryptophan catabolites (TRYCATs) play a role in the pathophysiology of de …
This paper reviews the body of evidence that not only tryptophan and consequent 5-HT depletion, but also induction of indoleamine 2,3 …
Mechanisms of Inflammation-Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms.
Strasser B, Sperner-Unterweger B, Fuchs D, Gostner JM. Strasser B, et al. Curr Top Behav Neurosci. 2017;31:95-115. doi: 10.1007/7854_2016_23. Curr Top Behav Neurosci. 2017. PMID: 27278641 Review.
Metabolic parameters have a direct role in the regulation of immune cell function. Thereby the inflammation-induced metabolism of aromatic amino acids, most importantly of tryptophan and phenylalanine, plays a central role. ...Monitoring of these immunometabolic parameters …
Metabolic parameters have a direct role in the regulation of immune cell function. Thereby the inflammation-induced metabolism of aro …
COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route.
Mingoti MED, Bertollo AG, Simões JLB, Francisco GR, Bagatini MD, Ignácio ZM. Mingoti MED, et al. J Mol Neurosci. 2022 Jun;72(6):1166-1181. doi: 10.1007/s12031-022-02004-y. Epub 2022 Mar 23. J Mol Neurosci. 2022. PMID: 35322375 Free PMC article. Review.
Some studies provide evidence on the onset or exacerbation of major depressive disorder (MDD), among other psychiatric disorders due to COVID-19. Oxidative stress and neuroinflammation are associated conditions, especially in the more severe form of MDD and i …
Some studies provide evidence on the onset or exacerbation of major depressive disorder (MDD), among other psychiatric …
Inflammation in cancer and depression: a starring role for the kynurenine pathway.
Sforzini L, Nettis MA, Mondelli V, Pariante CM. Sforzini L, et al. Psychopharmacology (Berl). 2019 Oct;236(10):2997-3011. doi: 10.1007/s00213-019-05200-8. Epub 2019 Feb 26. Psychopharmacology (Berl). 2019. PMID: 30806743 Free PMC article.
Depression is a common comorbidity in cancer cases, but this is not only due to the emotional distress of having a life-threatening disease. ...In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role …
Depression is a common comorbidity in cancer cases, but this is not only due to the emotional distress of having a life-threatening d …
Indoleamine 2,3-dioxygenase and immune changes under antidepressive treatment in major depression in females.
Zoga M, Oulis P, Chatzipanagiotou S, Masdrakis VG, Pliatsika P, Boufidou F, Foteli S, Soldatos CR, Nikolaou C, Papageorgiou C. Zoga M, et al. In Vivo. 2014 Jul-Aug;28(4):633-8. In Vivo. 2014. PMID: 24982234
BACKGROUND/AIM: Indoleamine 2, 3-dioxygenase (IDO) induction has been suggested as a mechanism by which immune activation affects tryptophan metabolism and serotonin synthesis in major depressive disorder (MDD). ...IDO and TNFalpha concen …
BACKGROUND/AIM: Indoleamine 2, 3-dioxygenase (IDO) induction has been suggested as a mechanism by which immune activati …
Inflammatory biomarkers and depression.
Müller N, Myint AM, Schwarz MJ. Müller N, et al. Neurotox Res. 2011 Feb;19(2):308-18. doi: 10.1007/s12640-010-9210-2. Epub 2010 Jul 24. Neurotox Res. 2011. PMID: 20658274 Review.
Differences in the activation of the enzyme indoleamine 2,3-dioxygenase (IDO) and in the tryptophan-kynurenine metabolism resulting in an increased tryptophan and serotonin degradation and probably in an increased production of quinolinic acid might play a ke …
Differences in the activation of the enzyme indoleamine 2,3-dioxygenase (IDO) and in the tryptophan-kynurenine metaboli …
60 results