Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1999 1
2001 1
2002 2
2003 1
2004 2
2005 4
2006 3
2007 5
2008 9
2009 8
2010 12
2011 20
2012 12
2013 33
2014 36
2015 36
2016 41
2017 49
2018 42
2019 57
2020 75
2021 89
2022 83
2023 79
2024 84
2025 89
2026 16

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

806 results

Results by year

Filters applied: . Clear all
Page 1
Interferon-Inducible Transmembrane Protein 3 (IFITM3) Restricts Rotavirus Infection.
Pang Z, Hao P, Qu Q, Li L, Jiang Y, Xiao S, Jin N, Li C. Pang Z, et al. Viruses. 2022 Oct 30;14(11):2407. doi: 10.3390/v14112407. Viruses. 2022. PMID: 36366505 Free PMC article.
Therefore, we attempted to determine whether IFITM3 also restricts RV infection by using over-expression and knockout cell strains. ...Correspondingly, IFITM3-knockout cells were significantly susceptible compared to the normal cells. Furthermore, the IFN-induced an …
Therefore, we attempted to determine whether IFITM3 also restricts RV infection by using over-expression and knockout cell strains. . …
Interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity.
Jiménez-Munguía I, Beaven AH, Blank PS, Sodt AJ, Zimmerberg J. Jiménez-Munguía I, et al. Curr Opin Struct Biol. 2022 Dec;77:102467. doi: 10.1016/j.sbi.2022.102467. Epub 2022 Oct 25. Curr Opin Struct Biol. 2022. PMID: 36306674 Review.
Here, we focus on interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity. IFITM3 is predicted to block or stall viral fusion at an intermediate state, causing viral propagation to fail. After introducing IFITM3, we describe the general …
Here, we focus on interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity. IFITM3 is predicted to block …
The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer's disease.
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.
The expression of IFITM3 is increased with ageing and in mouse models that express familial Alzheimer's disease genes. ...IFITM3 protein is upregulated in tissue samples from a subset of patients with late-onset Alzheimer's disease that exhibit higher gamma-secretas …
The expression of IFITM3 is increased with ageing and in mouse models that express familial Alzheimer's disease genes. ...IFITM3 …
IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion.
Klein S, Golani G, Lolicato F, Lahr C, Beyer D, Herrmann A, Wachsmuth-Melm M, Reddmann N, Brecht R, Hosseinzadeh M, Kolovou A, Makroczyova J, Peterl S, Schorb M, Schwab Y, Brügger B, Nickel W, Schwarz US, Chlanda P. Klein S, et al. Cell Host Microbe. 2023 Apr 12;31(4):616-633.e20. doi: 10.1016/j.chom.2023.03.005. Epub 2023 Mar 31. Cell Host Microbe. 2023. PMID: 37003257 Free article.
Interferon-induced transmembrane protein 3 (IFITM3) inhibits the entry of numerous viruses through undefined molecular mechanisms. IFITM3 localizes in the endosomal-lysosomal system and specifically affects virus fusion with target cell membranes. ...
Interferon-induced transmembrane protein 3 (IFITM3) inhibits the entry of numerous viruses through undefined molecular mechanisms. …
Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's-related phenotypes.
Feng Y, Wang S, Yang D, Zheng W, Xia H, Zhu Q, Wang Z, Hu B, Jiang X, Qin X, Ni C, Pan W, Zhao Y, Pan S, Zhang Y, Song W. Feng Y, et al. Alzheimers Dement. 2025 Feb;21(2):e14543. doi: 10.1002/alz.14543. Epub 2025 Jan 14. Alzheimers Dement. 2025. PMID: 39807629 Free PMC article.
DISCUSSION: Knockdown of IFITM3 in CVECs alleviates AD pathology and cognitive impairment. Targeting cerebrovascular endothelial IFITM3 holds promise for AD treatment. ...Cerebrovascular endothelial IFITM3 could be a potential target for the treatment of AD.. …
DISCUSSION: Knockdown of IFITM3 in CVECs alleviates AD pathology and cognitive impairment. Targeting cerebrovascular endothelial I …
Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry.
Anafu AA, Bowen CH, Chin CR, Brass AL, Holm GH. Anafu AA, et al. J Biol Chem. 2013 Jun 14;288(24):17261-71. doi: 10.1074/jbc.M112.438515. Epub 2013 May 6. J Biol Chem. 2013. PMID: 23649619 Free PMC article.
Reovirus replication was also significantly reduced in IFITM3-expressing cells. Additionally, cells expressing an shRNA targeting IFITM3 exhibited a smaller decrease in infection after IFN treatment than the control cells, indicating that endogenous IFITM3 re …
Reovirus replication was also significantly reduced in IFITM3-expressing cells. Additionally, cells expressing an shRNA targeting …
Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease.
Zhao Y, Zhu XY, Ma W, Zhang Y, Yuan F, Kim SR, Tang H, Jordan K, Lerman A, Tchkonia T, Kirkland JL, Lerman LO. Zhao Y, et al. Cell Death Dis. 2025 May 10;16(1):372. doi: 10.1038/s41419-025-07666-1. Cell Death Dis. 2025. PMID: 40348745 Free PMC article.
MMT markers and TGF-beta/Smad3 expression also rose in these macrophages and decreased after IFITM3 or ITGB3 silencing. p16(INK-4a)-expressing macrophages may regulate interstitial fibrosis in RAS via MMT. This process is associated with elevated expression of ITGB3 and TG …
MMT markers and TGF-beta/Smad3 expression also rose in these macrophages and decreased after IFITM3 or ITGB3 silencing. p16(INK-4a)-e …
Interferon-Induced Transmembrane Protein 3 (IFITM3) Restricts PRRSV Replication via Post-Entry Mechanisms.
Katwal P, Aftab S, Nelson E, Hildreth M, Li S, Wang X. Katwal P, et al. Microorganisms. 2025 Jul 25;13(8):1737. doi: 10.3390/microorganisms13081737. Microorganisms. 2025. PMID: 40871241 Free PMC article.
IFITM3 over-expression reduced PRRSV replication, while the siRNA-induced knockdown of endogenous IFITM3 increased PRRSV RNA copies and virus titers. The colocalization of the virus with IFITM3 was observed at both 3 and 24 h post infection (hpi). Quantitativ …
IFITM3 over-expression reduced PRRSV replication, while the siRNA-induced knockdown of endogenous IFITM3 increased PRRSV RNA c …
Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A.
Chen L, Zhu L, Chen J. Chen L, et al. Biomed Res Int. 2021 Mar 3;2021:6652147. doi: 10.1155/2021/6652147. eCollection 2021. Biomed Res Int. 2021. Retraction in: Biomed Res Int. 2022 Apr 6;2022:9790782. doi: 10.1155/2022/9790782. PMID: 33763481 Free PMC article. Retracted.
Studies have shown that human interferon inducible transmembrane protein (hIFITMs) family proteins have broad-spectrum antiviral capabilities. ...
Studies have shown that human interferon inducible transmembrane protein (hIFITMs) family proteins have broad-sp …
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia.
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, Rangaraju S. Sudwarts A, et al. Mol Neurodegener. 2022 May 7;17(1):33. doi: 10.1186/s13024-022-00535-x. Mol Neurodegener. 2022. PMID: 35526014 Free PMC article.
The consensus from in vitro and in vivo findings showed that loss of Bin1 impaired the ability of microglia to mount type 1 interferon responses to proinflammatory challenge, particularly the upregulation of a critical type 1 immune response gene, Ifitm3. CONCLUSIONS: Our …
The consensus from in vitro and in vivo findings showed that loss of Bin1 impaired the ability of microglia to mount type 1 interferon respo …
806 results