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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1973 1
1975 3
1976 4
1977 1
1978 2
1979 4
1980 15
1981 21
1982 44
1983 68
1984 97
1985 126
1986 208
1987 314
1988 477
1989 606
1990 661
1991 867
1992 955
1993 1163
1994 1209
1995 1334
1996 1374
1997 1411
1998 1521
1999 1562
2000 1552
2001 1595
2002 1600
2003 1734
2004 1856
2005 1914
2006 1917
2007 1975
2008 2062
2009 2080
2010 2133
2011 2216
2012 2144
2013 2268
2014 2252
2015 2171
2016 2042
2017 1990
2018 1941
2019 1942
2020 2056
2021 2128
2022 1917
2023 1752
2024 1807
2025 2070
2026 1098

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60,432 results

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Page 1
IGF/IGF-1R signal pathway in pain: a promising therapeutic target.
Ma L, Zhao W, Huang S, Xu F, Wang Y, Deng D, Zhang T, Shu S, Chen X. Ma L, et al. Int J Biol Sci. 2023 Jul 3;19(11):3472-3482. doi: 10.7150/ijbs.84353. eCollection 2023. Int J Biol Sci. 2023. PMID: 37497005 Free PMC article. Review.
The regulation of IGF/IGF-1R pathway has obvious effect on pain. This review summarized and discussed the therapeutic potential of IGF/IGF-1R signal pathway for pain. It also summarized that IGF/IGF-1R regulates pain by acting on neuronal …
The regulation of IGF/IGF-1R pathway has obvious effect on pain. This review summarized and discussed the therapeutic potentia …
Drugging IGF-1R in cancer: New insights and emerging opportunities.
Wang P, Mak VC, Cheung LW. Wang P, et al. Genes Dis. 2022 Mar 23;10(1):199-211. doi: 10.1016/j.gendis.2022.03.002. eCollection 2023 Jan. Genes Dis. 2022. PMID: 37013053 Free PMC article. Review.
The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages. Here …
The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor …
Understanding IGF-II Action through Insights into Receptor Binding and Activation.
Blyth AJ, Kirk NS, Forbes BE. Blyth AJ, et al. Cells. 2020 Oct 12;9(10):2276. doi: 10.3390/cells9102276. Cells. 2020. PMID: 33053840 Free PMC article. Review.
It is also unique in the IGF system as it acts through both IGF-1R and insulin receptor isoform A (IR-A). Despite this, IGF-II is the least investigated ligand of the IGF system. This review will explore recent developments in IGF-II research in …
It is also unique in the IGF system as it acts through both IGF-1R and insulin receptor isoform A (IR-A). Despite this, IGF …
Disorders of IGFs and IGF-1R signaling pathways.
Forbes BE, Blyth AJ, Wit JM. Forbes BE, et al. Mol Cell Endocrinol. 2020 Dec 1;518:111035. doi: 10.1016/j.mce.2020.111035. Epub 2020 Sep 15. Mol Cell Endocrinol. 2020. PMID: 32941924 Review.
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). ...This review …
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiologic …
New insights on the cardiovascular effects of IGF-1.
Macvanin M, Gluvic Z, Radovanovic J, Essack M, Gao X, Isenovic ER. Macvanin M, et al. Front Endocrinol (Lausanne). 2023 Feb 9;14:1142644. doi: 10.3389/fendo.2023.1142644. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36843588 Free PMC article.
The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. ...We also discuss progress in therapeutic interve …
The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventio …
The role of IGF/IGF-1R signaling in the regulation of cancer stem cells.
Liu F, Ye S, Zhao L, Niu Q. Liu F, et al. Clin Transl Oncol. 2024 Dec;26(12):2924-2934. doi: 10.1007/s12094-024-03561-x. Epub 2024 Jun 12. Clin Transl Oncol. 2024. PMID: 38865036 Review.
However, the effect of IGF/IGF-1R signaling on stemness and CSCs and the underlying mechanisms are still controversial. Based on the similarity between CSCs and normal stem cells, this review discusses emerging data on the functions of IGF/IGF-1R signa …
However, the effect of IGF/IGF-1R signaling on stemness and CSCs and the underlying mechanisms are still controversial. Based …
New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations.
Janssen JAMJL. Janssen JAMJL. Cells. 2020 Apr 2;9(4):862. doi: 10.3390/cells9040862. Cells. 2020. PMID: 32252327 Free PMC article. Review.
IGF-I and IGF-II primarily activate the IGF-I receptor (IGF-IR), which is present on the cell surface. ...In addition, activation of the IGF-IR has been found to be essential for the growth of cancers. The conventional view in the past was that …
IGF-I and IGF-II primarily activate the IGF-I receptor (IGF-IR), which is present on the cell surface. ...In add …
Mechanisms of putative IGF-I receptor resistance in active acromegaly.
Janssen JAMJL. Janssen JAMJL. Growth Horm IGF Res. 2020 Jun;52:101319. doi: 10.1016/j.ghir.2020.101319. Epub 2020 Apr 6. Growth Horm IGF Res. 2020. PMID: 32339897 Free article. Review.
In this review evidence will be discussed that in active acromegaly chronically elevated IGF-I, insulin and soluble Klotho (S-Klotho) levels play a pathophysiological role in the development of IGF-I receptor (IGF-IR) resistance. It is postulated that as soon …
In this review evidence will be discussed that in active acromegaly chronically elevated IGF-I, insulin and soluble Klotho (S-Klotho) …
Targeting the IGF-1R in prostate and colorectal cancer: reasons behind trial failure and future directions.
Tufail M, Wu C. Tufail M, et al. Ther Deliv. 2022 Mar;13(3):167-186. doi: 10.4155/tde-2021-0060. Epub 2022 Jan 14. Ther Deliv. 2022. PMID: 35029130 Review.
IGF-1Rs enact a significant part in cancer growth and its progress. IGF-1R inhibitors were encouraged in the early trials, but the patients did not benefit due to the unavailability of predictive biomarkers and IGF-1R system complexity. However, the linkage b …
IGF-1Rs enact a significant part in cancer growth and its progress. IGF-1R inhibitors were encouraged in the early trials, but …
Recent update on IGF-1/IGF-1R signaling axis as a promising therapeutic target for triple-negative breast cancer.
Kumar S, Chaudhri S. Kumar S, et al. Pathol Res Pract. 2024 Nov;263:155620. doi: 10.1016/j.prp.2024.155620. Epub 2024 Sep 26. Pathol Res Pract. 2024. PMID: 39357179 Review.
In the last five to seven years, marvelous work has been done to explore the role of IGF-1/IGF-1R axis in TNBC. In the present review, starting from the general introduction to IGF-1/IGF-1R pathway an up-to-date discussion was focused on its role in TN …
In the last five to seven years, marvelous work has been done to explore the role of IGF-1/IGF-1R axis in TNBC. In the present …
60,432 results
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