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Page 1
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
White A, Stremming J, Wesolowski SR, Al-Juboori SI, Dobrinskikh E, Limesand SW, Brown LD, Rozance PJ. White A, et al. Am J Physiol Endocrinol Metab. 2025 Jan 1;328(1):E116-E125. doi: 10.1152/ajpendo.00259.2024. Epub 2024 Dec 16. Am J Physiol Endocrinol Metab. 2025. PMID: 39679943 Free PMC article.
In this study, FGR fetal sheep received either IGF-1 LR3 treatment at 1.17 0.12 mug.kg(-1).h(-1) (LR3; n = 7) or vehicle (VEH; n = 7) for 1 wk. ...In summary, a 1-wk IGF-1 LR3 treatment did not improve growth in FGR fetuses. Insu …
In this study, FGR fetal sheep received either IGF-1 LR3 treatment at 1.17 0.12 mug.kg(-1).h(-1) (LR3; n = 7) …
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.
Lu Z, Liu N, Huang H, Wang Y, Tu T, Qin X, Wang X, Zhang J, Su X, Tian J, Bai Y, Luo H, Yao B, Zhang H. Lu Z, et al. Appl Microbiol Biotechnol. 2023 Jul;107(14):4543-4551. doi: 10.1007/s00253-023-12606-0. Epub 2023 Jun 1. Appl Microbiol Biotechnol. 2023. PMID: 37261455
Furthermore, purified IGF-1 and LR3 IGF-1 display excellent bioactivity of cell proliferation compared to the standard IGF-1. ...KEY POINTS: Human IGF-1 and LR3 IGF-1 are produced in the P. past …
Furthermore, purified IGF-1 and LR3 IGF-1 display excellent bioactivity of cell proliferation compared to …
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
White A, Stremming J, Brown LD, Rozance PJ. White A, et al. J Dev Orig Health Dis. 2023 Jun;14(3):353-361. doi: 10.1017/S2040174423000090. Epub 2023 Apr 28. J Dev Orig Health Dis. 2023. PMID: 37114757 Free PMC article.
We first infused late gestation fetal sheep (n = 10) with either IGF-1 LR3 (IGF-1) or vehicle control (CON) and measured basal insulin secretion and in vivo GSIS utilizing a hyperglycemic clamp. ...Fetal plasma insulin concentrations decreased w …
We first infused late gestation fetal sheep (n = 10) with either IGF-1 LR3 (IGF-1) or vehicle control (CO …
Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep.
Stremming J, White A, Donthi A, Batt DG, Hetrick B, Chang EI, Wesolowski SR, Seefeldt MB, McCurdy CE, Rozance PJ, Brown LD. Stremming J, et al. Front Physiol. 2022 Aug 25;13:954948. doi: 10.3389/fphys.2022.954948. eCollection 2022. Front Physiol. 2022. PMID: 36091374 Free PMC article.
However, LR3 IGF-1 has a low affinity for IGF binding proteins (IGFBP), thus reducing physiologic regulation of IGF-1 bioavailability. The peptide sequences for LR3 IGF-1 and sheep IGF-1 also differ. To overcom …
However, LR3 IGF-1 has a low affinity for IGF binding proteins (IGFBP), thus reducing physiologic regulation of IGF …
Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.
Jonker SS, Giraud GD, Chang EI, Elman MR, Louey S. Jonker SS, et al. FASEB J. 2020 Aug;34(8):10041-10055. doi: 10.1096/fj.202000215R. Epub 2020 Jun 23. FASEB J. 2020. PMID: 32573852 Free PMC article.
As loss of contractile function in heart disease could often be mitigated by increased cardiomyocyte number, expansion of cardiomyocyte endowment paired with increased vascular supply is a desirable therapeutic goal. Insulin-like growth factor 1 (IGF-1) admin …
As loss of contractile function in heart disease could often be mitigated by increased cardiomyocyte number, expansion of cardiomyocyte endo …
IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.
Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. Stremming J, et al. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E527-E538. doi: 10.1152/ajpendo.00453.2020. Epub 2021 Jan 11. Am J Physiol Endocrinol Metab. 2021. PMID: 33427051 Free PMC article.

By the end of the infusion, fetal weights were not statistically different between groups (SAL: 3.260 0.211 kg, LR3 IGF-1: 3.682 0.183; P = 0.15). Fetal heart, adrenal gland, and spleen weights were higher (P < 0.05), and insulin was lower in LR3

…
By the end of the infusion, fetal weights were not statistically different between groups (SAL: 3.260 0.211 kg, LR3 IGF-1 …
Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.
Yavuz E, Sağır MS, Ercan A, Erginer M, Barlas FB, Sakarya D, Kılıç Ş, Ölçeroğlu B, Yardibi H, Kalaycılar İB, Demiröz A. Yavuz E, et al. Int J Biol Macromol. 2025 Nov;329(Pt 2):147888. doi: 10.1016/j.ijbiomac.2025.147888. Epub 2025 Sep 25. Int J Biol Macromol. 2025. PMID: 41015370
This study introduces the first-ever decellularized plant-based nerve conduit, fabricated from Alstroemeria stem material, integrated with GelMA, and featuring controlled release of Insulin-like Growth Factor Long Arginine 3 (IGF-1 LR3) for enhanced axonal re …
This study introduces the first-ever decellularized plant-based nerve conduit, fabricated from Alstroemeria stem material, integrated with G …
Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ. White A, et al. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1138-E1147. doi: 10.1152/ajpendo.00623.2020. Epub 2021 May 3. Am J Physiol Endocrinol Metab. 2021. PMID: 33938236 Free PMC article.
Late gestation fetal sheep received infusions with IGF-1 LR3 (IGF-1, n = 8), an analog of IGF-1 with low affinity for the IGF binding proteins and high affinity for the IGF-1 receptor, or vehicle control (CON, n = 9). …
Late gestation fetal sheep received infusions with IGF-1 LR3 (IGF-1, n = 8), an analog of IGF-1 …
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
Engel MG, Narayan S, Cui MH, Branch CA, Zhang X, Gandy SE, Ehrlich M, Huffman DM. Engel MG, et al. J Alzheimers Dis. 2025 Jan;103(1):113-126. doi: 10.1177/13872877241299056. Epub 2024 Nov 29. J Alzheimers Dis. 2025. PMID: 39610283 Free PMC article.
BACKGROUND: Insulin-like growth factor-1 (IGF-1) promotes neurogenesis, cell survival, and glial function, making it a promising candidate therapy in Alzheimer's disease (AD). OBJECTIVE: Long arginine 3-IGF-1 (LR3-IGF-1) is …
BACKGROUND: Insulin-like growth factor-1 (IGF-1) promotes neurogenesis, cell survival, and glial function, making it a …
Na+ transport across rumen epithelium of hay-fed sheep is acutely stimulated by the peptide IGF-1 in vitro.
Shen Z, Martens H, Schweigel-Röntgen M. Shen Z, et al. Exp Physiol. 2012 Apr;97(4):497-505. doi: 10.1113/expphysiol.2011.061580. Epub 2012 Jan 6. Exp Physiol. 2012. PMID: 22227200 Free article.
At concentrations ranging from 20 to 100 mug l(-1), serosal LR3-IGF-1, a recombinant analogue of IGF-1, rapidly (within 30 min) stimulated the mucosal-to-serosal Na(+) flux (J(ms)Na) and consequently the net Na(+) flux (J(net)Na). Compared with …
At concentrations ranging from 20 to 100 mug l(-1), serosal LR3-IGF-1, a recombinant analogue of IGF-1, r …
43 results