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IGF-1 inhibits MPTP/MPP(+)-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER.
Wang XW, Yuan LJ, Yang Y, Zhang M, Chen WF. Wang XW, et al. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E734-E743. doi: 10.1152/ajpendo.00071.2020. Epub 2020 Aug 31. Am J Physiol Endocrinol Metab. 2020. PMID: 32865008
IGF-1 could inhibit the neurotoxicity through promoting the phosphorylation of Akt and mammalian target of rapamycin (mTOR), which could also be antagonized by JB-1 or G15. These data suggest that IGF-1 inhibits MPTP/MPP(+)-
IGF-1 could inhibit the neurotoxicity through promoting the phosphorylation of Akt and mammalian target of rapamycin (m
IGF-1 receptor antagonism inhibits autophagy.
Renna M, Bento CF, Fleming A, Menzies FM, Siddiqi FH, Ravikumar B, Puri C, Garcia-Arencibia M, Sadiq O, Corrochano S, Carter S, Brown SD, Acevedo-Arozena A, Rubinsztein DC. Renna M, et al. Hum Mol Genet. 2013 Nov 15;22(22):4528-44. doi: 10.1093/hmg/ddt300. Epub 2013 Jun 25. Hum Mol Genet. 2013. PMID: 23804751 Free PMC article.
This pathway is upstream of mTORC1, a negative regulator of autophagy. Thus, we expected autophagy to be activated by insulin-like growth factor-1 (IGF-1) inhibition, which could account for many of its beneficial effects. ...Finally, wit …
This pathway is upstream of mTORC1, a negative regulator of autophagy. Thus, we expected autophagy to be activated by insulin- …
MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R.
Ge YY, Shi Q, Zheng ZY, Gong J, Zeng C, Yang J, Zhuang SM. Ge YY, et al. Oncotarget. 2014 Aug 15;5(15):6218-28. doi: 10.18632/oncotarget.2189. Oncotarget. 2014. PMID: 25026290 Free PMC article.
Simultaneously, miR-100 expression led to increased fraction of cells with Annexin V-staining and loss of mitochondrial potential, implying that miR-100 may promote the Atg7-dependent autophagy and subsequent apoptotic cell death. Consistently, mouse xenograft models revea …
Simultaneously, miR-100 expression led to increased fraction of cells with Annexin V-staining and loss of mitochondrial potential, implying …