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470 results

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Page 1
Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2.
Li D, Liu Y, Li C, Zhou Z, Gao K, Bao H, Yang J, Xue G, Yin D, Zhao X, Shen K, Zhang L, Li J, Li C, Song J, Zhao L, Pei Y, Xuan L, Zhang Y, Lu Y, Zhang ZR, Yang B, Li Y, Pan Z. Li D, et al. Circulation. 2024 Jul 9;150(2):111-127. doi: 10.1161/CIRCULATIONAHA.123.067517. Epub 2024 May 10. Circulation. 2024. PMID: 38726666
Optical mapping was used to determine atrial conduction velocity and action potential duration. Atrial myocyte action potential duration and inward rectifying K(+) current (I(K1)) were recorded using whole-cell patch clamps. ...In the atrium of SPX-KO …
Optical mapping was used to determine atrial conduction velocity and action potential duration. Atrial myocyte action potential …
The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis.
Dhamoon AS, Jalife J. Dhamoon AS, et al. Heart Rhythm. 2005 Mar;2(3):316-24. doi: 10.1016/j.hrthm.2004.11.012. Heart Rhythm. 2005. PMID: 15851327 Review.
The cardiac inwardly rectifying potassium current (I(K1)) stabilizes the resting membrane potential and is responsible for shaping the initial depolarization and final repolarization of the action potential. The inwardly rectifying …
The cardiac inwardly rectifying potassium current (I(K1)) stabilizes the resting membrane potential and i …
Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.
Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A, Bartelt L, Stelzer L, Haghighi F, Pietras J, Windel H, Pedrosa NDI, Rapedius M, Doering Y, Solano R, Hindmarsh R, Shi R, Tiburcy M, Bruegmann T, Kutschka I, Streckfuss-Bömeke K, Kensah G, Cyganek L, Zimmermann WH, Voigt N. Seibertz F, et al. Cardiovasc Res. 2023 Dec 19;119(16):2623-2637. doi: 10.1093/cvr/cvad143. Cardiovasc Res. 2023. PMID: 37677054 Free PMC article.
Selective IK,ACh blockade with tertiapin reduced basal inward-rectifier K+ current only in iPSC-aCM subjected to TP, thereby unmasking an agonist-independent constitutively active IK,ACh. ...In addition, continuous TP (7 days) led to (i) increased amplitude of in …
Selective IK,ACh blockade with tertiapin reduced basal inward-rectifier K+ current only in iPSC-aCM subjected to TP, thereby u …
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms.
Giammarino L, Matas L, Alerni N, Horváth A, Vashanthakumar V, Nimani S, Barbieri M, Bains S, Lopez R, Louradour J, Ördög B, Hof T, Maguy A, Conte G, Auricchio A, Schotten U, Odening KE. Giammarino L, et al. Cardiovasc Res. 2025 Jul 31;121(8):1215-1227. doi: 10.1093/cvr/cvaf074. Cardiovasc Res. 2025. PMID: 40272446 Free PMC article.
In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence in the younger population, focusing on IK1, a cardiac ion current important for action potential (AP) stability and triggered a …
In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence in the y …
Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis.
Reilly L, Eckhardt LL. Reilly L, et al. Heart Rhythm. 2021 Aug;18(8):1423-1434. doi: 10.1016/j.hrthm.2021.04.008. Epub 2021 Apr 20. Heart Rhythm. 2021. PMID: 33857643 Free PMC article. Review.
Potassium inward rectifier channel Kir2 is an important component of terminal cardiac repolarization and resting membrane stability. This functionality is part of balanced cardiac excitability and is a defining feature of excitable car …
Potassium inward rectifier channel Kir2 is an important component of terminal cardiac repolarization and resting …
Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes.
Horváth A, Lemoine MD, Löser A, Mannhardt I, Flenner F, Uzun AU, Neuber C, Breckwoldt K, Hansen A, Girdauskas E, Reichenspurner H, Willems S, Jost N, Wettwer E, Eschenhagen T, Christ T. Horváth A, et al. Stem Cell Reports. 2018 Mar 13;10(3):822-833. doi: 10.1016/j.stemcr.2018.01.012. Epub 2018 Feb 8. Stem Cell Reports. 2018. PMID: 29429959 Free PMC article.
Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative resting membrane potential (RMP), which is attributed to small inward rectifier currents (I(K1)). Here, I(K1) was measured in hiPSC-CMs (proprietary and commerci …
Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative resting membrane potential (RMP), w …
Cardiac strong inward rectifier potassium channels.
Anumonwo JM, Lopatin AN. Anumonwo JM, et al. J Mol Cell Cardiol. 2010 Jan;48(1):45-54. doi: 10.1016/j.yjmcc.2009.08.013. Epub 2009 Aug 22. J Mol Cell Cardiol. 2010. PMID: 19703462 Free PMC article. Review.
Cardiac I(K1) and I(KACh) are the major potassium currents displaying classical strong inward rectification, a unique property that is critical for their roles in cardiac excitability. ...It has become increasingly clear that the contribution of I(K1) and I(K …
Cardiac I(K1) and I(KACh) are the major potassium currents displaying classical strong inward rectification, a unique property …
Pharmacology of cardiac potassium channels.
Tamargo J, Caballero R, Gómez R, Valenzuela C, Delpón E. Tamargo J, et al. Cardiovasc Res. 2004 Apr 1;62(1):9-33. doi: 10.1016/j.cardiores.2003.12.026. Cardiovasc Res. 2004. PMID: 15023549 Review.
Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of K+ ions across the cell membrane along its electrochemical gradient. They regulate the resting membrane potential, the frequency of pacemaker cells and …
Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of K+ ions across the cell membrane …
Pharmacology of cardiac potassium channels.
Li GR, Dong MQ. Li GR, et al. Adv Pharmacol. 2010;59:93-134. doi: 10.1016/S1054-3589(10)59004-5. Adv Pharmacol. 2010. PMID: 20933200 Review.
Cardiac K(+) channels are cardiomyocyte membrane proteins that regulate K(+) ion flow across the cell membrane on the electrochemical gradient and determine the resting membrane potential and the cardiac action potential mor …
Cardiac K(+) channels are cardiomyocyte membrane proteins that regulate K(+) ion flow across the cell membrane on the e …
Caveolin-3 Microdomain: Arrhythmia Implications for Potassium Inward Rectifier and Cardiac Sodium Channel.
Vaidyanathan R, Reilly L, Eckhardt LL. Vaidyanathan R, et al. Front Physiol. 2018 Nov 9;9:1548. doi: 10.3389/fphys.2018.01548. eCollection 2018. Front Physiol. 2018. PMID: 30473666 Free PMC article. Review.
Our lab has recently explored this sub-cellular microdomain and found that potassium inward rectifier Kir2.x is found in association with caveolin-3. The three cardiac Kir2.x isoforms (Kir2.1, Kir2.2, and Kir2.3) are the molecular correlates of I(K1) in the …
Our lab has recently explored this sub-cellular microdomain and found that potassium inward rectifier Kir2.x is found in assoc …
470 results