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301 results

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Page 1
HERG channel trafficking.
Ficker E, Dennis A, Kuryshev Y, Wible BA, Brown AM. Ficker E, et al. Novartis Found Symp. 2005;266:57-69; discussion 70-4, 95-9. Novartis Found Symp. 2005. PMID: 16050262 Review.
Mutations in the cardiac potassium channel hERG/IKr cause inherited long QT syndrome with increased susceptibility to ventricular arrhythmias. ...Therapeutic compounds that inhibit chaperone function produce a novel form of acquire …
Mutations in the cardiac potassium channel hERG/IKr cause inherited long QT syndrome with i …
The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.
Thomas D, Karle CA, Kiehn J. Thomas D, et al. Curr Pharm Des. 2006;12(18):2271-83. doi: 10.2174/138161206777585102. Curr Pharm Des. 2006. PMID: 16787254 Review.
Human ether-a-go-go-related gene (hERG) potassium channels conduct the rapid component of the delayed rectifier potassium current, IKr, which is crucial for repolarization of cardiac action potentials. Moderate hERG blockade may produce a …
Human ether-a-go-go-related gene (hERG) potassium channels conduct the rapid component of the delayed rectifier pota …
Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.
Keller SH, Platoshyn O, Yuan JX. Keller SH, et al. Cell Biochem Biophys. 2005;43(3):365-77. doi: 10.1385/CBB:43:3:365. Cell Biochem Biophys. 2005. PMID: 16244363
Hereditary long QT syndrome is a fatal arrhythmia associated with gene mutations in potassium and sodium channels that are expressed in ventricle. By employing heterologous expression and making comparisons to cells expressing wild-type human-et …
Hereditary long QT syndrome is a fatal arrhythmia associated with gene mutations in potassium and sodium chan …
hERG channel trafficking: novel targets in drug-induced long QT syndrome.
Dennis A, Wang L, Wan X, Ficker E. Dennis A, et al. Biochem Soc Trans. 2007 Nov;35(Pt 5):1060-3. doi: 10.1042/BST0351060. Biochem Soc Trans. 2007. PMID: 17956279 Review.
The cardiac potassium channel hERG (human ether-a-go-go-related gene) encodes the alpha-subunit of the rapid delayed rectifier current I(Kr) in the heart, which contributes to terminal repolarization in human cardiomyocytes. Direct block of hERG/I(Kr) …
The cardiac potassium channel hERG (human ether-a-go-go-related gene) encodes the alpha-subunit of the rapid delayed re …
A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2.
Gu K, Qian D, Qin H, Cui C, Fernando WCHA, Wang D, Wang J, Cao K, Chen M. Gu K, et al. Pflugers Arch. 2021 Feb;473(2):219-229. doi: 10.1007/s00424-021-02518-1. Epub 2021 Jan 15. Pflugers Arch. 2021. PMID: 33449212
Mutations in hERG (human ether-a-go-go-related gene) potassium channel are closely associated with long QT syndromes. By direct Sanger sequencing, we identified a novel KCNH2 mutation W410R in the patient with long QT syndrome …
Mutations in hERG (human ether-a-go-go-related gene) potassium channel are closely associated with long QT …
miRNAs Regulate hERG.
Lian J, Guo J, Huang X, Yang XI, Huang G, Mao H, Sun HH, Ba Y, Zhou J. Lian J, et al. J Cardiovasc Electrophysiol. 2016 Dec;27(12):1472-1482. doi: 10.1111/jce.13084. Epub 2016 Sep 26. J Cardiovasc Electrophysiol. 2016. PMID: 27558843
Impairment of hERG function is believed to be a mechanism causing long-QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation of the hERG pathway. ...Confocal microscopy showed that all 4 miRNAs …
Impairment of hERG function is believed to be a mechanism causing long-QT syndromes (LQTS). Growing evidences have show …
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.
Helliwell MV, Zhang Y, El Harchi A, Dempsey CE, Hancox JC. Helliwell MV, et al. Pharmaceuticals (Basel). 2023 Aug 24;16(9):1204. doi: 10.3390/ph16091204. Pharmaceuticals (Basel). 2023. PMID: 37765012 Free PMC article.
hERG (human Ether-a-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (I(Kr)) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form o …
hERG (human Ether-a-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (I(Kr)) …
Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.
Witchel HJ, Hancox JC. Witchel HJ, et al. Clin Exp Pharmacol Physiol. 2000 Oct;27(10):753-66. doi: 10.1046/j.1440-1681.2000.03337.x. Clin Exp Pharmacol Physiol. 2000. PMID: 11022966 Review.
1. Long QT syndrome (LQTS) is a cardiac disorder characterized by syncope, seizures and sudden death; it can be congenital, idiopathic, or iatrogenic. 2. Long QT syndrome is so-named because of the connection observed between the distinct …
1. Long QT syndrome (LQTS) is a cardiac disorder characterized by syncope, seizures and sudden death; it can be congeni …
Drug-induced QT interval prolongation--regulatory guidance and perspectives on hERG channel studies.
Shah RR. Shah RR. Novartis Found Symp. 2005;266:251-80; discussion 280-5. Novartis Found Symp. 2005. PMID: 16050273 Review.
Other drugs have been denied regulatory approval because of their 'QT liability'. This mechanism-based toxicity results principally from inhibition of IKr, the rapid component of delayed rectifier potassium current. ...Among the battery of non-dinical tests u …
Other drugs have been denied regulatory approval because of their 'QT liability'. This mechanism-based toxicity results principally f …
Rescue of expression and function of long QT syndrome-causing mutant hERG channels by enhancing channel stability in the plasma membrane.
Davis J, Cornwell JD, Campagna N, Guo J, Li W, Yang T, Wang T, Zhang S. Davis J, et al. J Biol Chem. 2024 Aug;300(8):107526. doi: 10.1016/j.jbc.2024.107526. Epub 2024 Jul 2. J Biol Chem. 2024. PMID: 38960041 Free PMC article.
The human ether-a-go-go-related gene (hERG) encodes the Kv11.1 (or hERG) channel that conducts the rapidly activating delayed rectifier potassium current (I(Kr)). Naturally occurring mutations in hERG impair the channel function and cause …
The human ether-a-go-go-related gene (hERG) encodes the Kv11.1 (or hERG) channel that conducts the rapidly activating d …
301 results