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2001 1
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67 results

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Page 1
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A. Folkersen L, et al. Nat Metab. 2020 Oct;2(10):1135-1148. doi: 10.1038/s42255-020-00287-2. Epub 2020 Oct 16. Nat Metab. 2020. PMID: 33067605 Free PMC article.
This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of …
This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, I …
Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice.
Zhang J, Yang Z, Liang Z, Wang M, Hu C, Chang C, Shi L, Ji Q, Liu L. Zhang J, et al. Mediators Inflamm. 2021 Apr 17;2021:6611085. doi: 10.1155/2021/6611085. eCollection 2021. Mediators Inflamm. 2021. PMID: 33958974 Free PMC article.
BACKGROUND: Interleukin-16 (IL-16) is an important inflammatory regulator and has been shown to have a powerful effect on the regulation of the inflammatory response. ...CONCLUSIONS: The anti-IL-16 nAb protects against DOX-induced card …
BACKGROUND: Interleukin-16 (IL-16) is an important inflammatory regulator and has been shown to have a powerful …
Anti-Interleukin-16 Neutralizing Antibody Treatment Alleviates Sepsis-Induced Cardiac Injury and Dysfunction via the Nuclear Factor Erythroid-2 Related Factor 2 Pathway in Mice.
Zhang J, Yang Z, Liang Z, Wang M, Hu C, Chang C, Shi L, Ji Q, Liu L. Zhang J, et al. Oxid Med Cell Longev. 2021 Feb 13;2021:6616422. doi: 10.1155/2021/6616422. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33628366 Free PMC article.
Then, IL-16 was neutralized, and the effects on lipopolysaccharide- (LPS-) induced cardiac injury were detected. ...Neutralization of IL-16 may be a beneficial strategy for the prevention of cardiac injury and dysfunction in sepsis patien …
Then, IL-16 was neutralized, and the effects on lipopolysaccharide- (LPS-) induced cardiac injury were detected. ...Neu …
Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
Tamaki S, Mano T, Sakata Y, Ohtani T, Takeda Y, Kamimura D, Omori Y, Tsukamoto Y, Ikeya Y, Kawai M, Kumanogoh A, Hagihara K, Ishii R, Higashimori M, Kaneko M, Hasuwa H, Miwa T, Yamamoto K, Komuro I. Tamaki S, et al. PLoS One. 2013 Jul 19;8(7):e68893. doi: 10.1371/journal.pone.0068893. Print 2013. PLoS One. 2013. PMID: 23894370 Free PMC article.
METHODS AND RESULTS: An analysis by multiplex-bead array assay revealed that serum interleukin-16 (IL-16) levels were specifically elevated in patients with HFpEF compared with HFrEF and controls. ...The cardiac expression of IL-16 …
METHODS AND RESULTS: An analysis by multiplex-bead array assay revealed that serum interleukin-16 (IL-16) levels …
IL-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis.
Elssner A, Doseff AI, Duncan M, Kotur M, Wewers MD. Elssner A, et al. J Immunol. 2004 Jun 15;172(12):7721-5. doi: 10.4049/jimmunol.172.12.7721. J Immunol. 2004. PMID: 15187155
Because pro-IL-16 is cleaved to its bioactive mature form by caspase-3, and caspase-3 is also the pivotal effector of apoptosis in monocytes, we asked whether IL-16 release occurs in monocytes that undergo spontaneous apoptosis. ...This apoptosis was p …
Because pro-IL-16 is cleaved to its bioactive mature form by caspase-3, and caspase-3 is also the pivotal effector of apoptosi …
Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model.
Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP. Kimura N, et al. J Heart Lung Transplant. 2011 Dec;30(12):1409-17. doi: 10.1016/j.healun.2011.08.017. J Heart Lung Transplant. 2011. PMID: 22055099
BACKGROUND: IL-16 promotes the recruitment of various cells expressing CD4, a receptor for IL-16. The precise role of IL-16 in transplant rejection remains unknown; therefore, the present study investigated the contribution of IL- …
BACKGROUND: IL-16 promotes the recruitment of various cells expressing CD4, a receptor for IL-16. The precise ro …
Molecular determinants of thrombosis recurrence risk across venous thromboembolism subtypes.
Munsch G, Thibord F, Bezerra OC, Brody JA, van Hylckama Vlieg A, Gourhant L, Chen MH, Samaria F, Germain M, Caro I, Suchon P, Olaso R, Wiggins KL, Saut N, Besse C, Goumidi L, Bacq D, Harrington LB, Boland A, Emmerich J, Smadja DM, Lemarié CA, Danckwardt S, Debette S, Deleuze JF, Jacqmin-Gadda H, Rodger MA, Gagnon F, Rosendaal FR, Johnson AD, Smith NL, Couturaud F, Morange PE, Trégouët DA. Munsch G, et al. Blood. 2025 Nov 6;146(19):2357-2369. doi: 10.1182/blood.2024027879. Blood. 2025. PMID: 40811855
Additionally, Mendelian randomization analyses identified 7 proteins as risk factors for recurrence: elevated plasma levels of coagulation factor XI, coagulation factor VIII, von Willebrand factor, histo-blood group ABO system transferase, and Golgi membrane protein 2; and decrea …
Additionally, Mendelian randomization analyses identified 7 proteins as risk factors for recurrence: elevated plasma levels of coagulation f …
GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.
Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X, Chu WM. Li ZW, et al. Gastroenterology. 2019 Jun;156(8):2297-2312. doi: 10.1053/j.gastro.2019.02.040. Epub 2019 Mar 2. Gastroenterology. 2019. PMID: 30836096 Free PMC article.
Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor.
Brösecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro AB, Rubenbauer L, Rao VS, Burlein S, Genser B, Reichel M, Aronson PS, Coca S, Knauf F. Brösecke F, et al. Sci Rep. 2024 May 17;14(1):11323. doi: 10.1038/s41598-024-61808-7. Sci Rep. 2024. PMID: 38760468 Free PMC article.
In a cohort of 104 US patients with kidney failure requiring dialysis (cohort 1), we measured 21 inflammatory markers. As IL-16 was the only cytokine to correlate with oxalate, we focused further investigations on IL-16. We searched for associations be …
In a cohort of 104 US patients with kidney failure requiring dialysis (cohort 1), we measured 21 inflammatory markers. As IL-16 …
67 results