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Page 1
MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation.
Zhang Y, Lin W, Yang Y, Zhu S, Chen Y, Wang H, Teng L. Zhang Y, et al. Cancer Lett. 2024 Jun 1;591:216878. doi: 10.1016/j.canlet.2024.216878. Epub 2024 Apr 10. Cancer Lett. 2024. PMID: 38609001 Free article.
In human gastric cancer tissues, the expression of IL13RA1, the receptor for IL-13, positively correlates with the expression of MEF2D and H1X. ...Targeting MEF2D could therefore be a promising therapeutic strategy for the clinical management of gastric cancer
In human gastric cancer tissues, the expression of IL13RA1, the receptor for IL-13, positively correlates with the expression …
IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
Aranda CJ, Gonzalez-Kozlova E, Saunders SP, Fernandes-Braga W, Ota M, Narayanan S, He JS, Del Duca E, Swaroop B, Gnjatic S, Shattner G, Reibman J, Soter NA, Guttman-Yassky E, Curotto de Lafaille MA. Aranda CJ, et al. Allergy. 2023 Mar;78(3):752-766. doi: 10.1111/all.15601. Epub 2022 Dec 19. Allergy. 2023. PMID: 36445014 Free PMC article.
RESULTS: We identified a novel population of IgG memory B cells characterized by the expression of IL-4/IL-13 regulated genes FCER2/CD23, IL4R, IL13RA1, and IGHE, denoting a history of differentiation during type 2 immune responses. ...
RESULTS: We identified a novel population of IgG memory B cells characterized by the expression of IL-4/IL-13 regulated genes FCER2/CD23, IL …
Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.
Avlas S, Shani G, Rhone N, Itan M, Dolitzky A, Hazut I, Grisaru-Tal S, Gordon Y, Shoda T, Ballaban A, Ben-Baruch NM, Rochman M, Diesendruck Y, Nahary L, Bitton A, Halpern Z, Benhar I, Varol C, Rothenberg ME, Munitz A. Avlas S, et al. Allergy. 2023 Feb;78(2):464-476. doi: 10.1111/all.15510. Epub 2022 Sep 13. Allergy. 2023. PMID: 36070083 Free PMC article.
METHODS: Experimental EoE was induced in WT, Il13ra1(-/-) , and Krt14(Cre) /Il13ra1(fl/fl) mice by skin-sensitized using 4-ethoxymethylene-2-phenyl-2-oxazolin (OXA) followed by intraesophageal challenges. ...RESULTS: Induction of experimental EoE in mice lacking …
METHODS: Experimental EoE was induced in WT, Il13ra1(-/-) , and Krt14(Cre) /Il13ra1(fl/fl) mice by skin-sensitized using 4-eth …
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.
Barilla RM, Berard C, Sun L, Sandhu S, Zaghouani S, Iyer KS, Altun G, Su CW, Deguine J, Singh V, Hou Y, Kusumakar K, Rutlin ML, Rao M, Zaghouani H, Shi HN, Xavier RJ, Kuchroo VK. Barilla RM, et al. Science. 2025 May 22:eadn9850. doi: 10.1126/science.adn9850. Online ahead of print. Science. 2025. PMID: 40403128
Type 2 cytokines amplified NMU and CGRPbeta expression in PSNs, in vitro and in vivo, which was abrogated by PSN-specific Il13ra1 deletion. Deletion of Il13ra1 in PSNs impaired host defense to the gastrointestinal helminth Heligmosomoides polygyrus and blunted muscu …
Type 2 cytokines amplified NMU and CGRPbeta expression in PSNs, in vitro and in vivo, which was abrogated by PSN-specific Il13ra1 del …
Targeting of IL-4 and IL-13 receptors for cancer therapy.
Suzuki A, Leland P, Joshi BH, Puri RK. Suzuki A, et al. Cytokine. 2015 Sep;75(1):79-88. doi: 10.1016/j.cyto.2015.05.026. Epub 2015 Jun 15. Cytokine. 2015. PMID: 26088753 Review.
In certain cancers, the presence of these cytokine receptors may serve as biomarkers of cancer aggressiveness. In a series of studies, we reported that overexpression of IL-4 and IL-13 receptors on cancer cells provides targets for therapeutic agents for c
In certain cancers, the presence of these cytokine receptors may serve as biomarkers of cancer aggressiveness. In a series of …
Cancer gene therapy utilizing interleukin-13 receptor alpha2 chain.
Kawakami K. Kawakami K. Curr Gene Ther. 2005 Apr;5(2):213-23. doi: 10.2174/1566523053544227. Curr Gene Ther. 2005. PMID: 15853729 Review.
IL-13Ralpha2 chain on these cancer cells can be targeted with a receptor-directed cytotoxin termed IL13-PE to induce specific cancer cell killing, however, this molecule does not mediate cytotoxicity to cells that do not express or express low levels of IL-13Ralpha2 …
IL-13Ralpha2 chain on these cancer cells can be targeted with a receptor-directed cytotoxin termed IL13-PE to induce specific canc
Interleukin-13 (IL-13) pathway.
Kelly-Welch A, Hanson EM, Keegan AD. Kelly-Welch A, et al. Sci STKE. 2005 Jul 19;2005(293):cm8. doi: 10.1126/stke.2932005cm8. Sci STKE. 2005. PMID: 16030286
Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.
Shi J, Shen X, Kang Q, Yang X, Denzinger M, Kornmann M, Traub B. Shi J, et al. Int J Mol Sci. 2022 Mar 26;23(7):3659. doi: 10.3390/ijms23073659. Int J Mol Sci. 2022. PMID: 35409019 Free PMC article.
In search of new therapies for pancreatic cancer, cytokine pathways have attracted increasing interest in recent years. Cytokines play a vital role in the crosstalk between tumour cells and the tumour microenvironment. ...Overall, our results indicate the vital role of IL- …
In search of new therapies for pancreatic cancer, cytokine pathways have attracted increasing interest in recent years. Cytokines pla …
Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients' survival.
Moreno DA, da Silva LS, Gomes I, Leal LF, Berardinelli GN, Gonçalves GM, Pereira CA, Santana IVV, Matsushita MM, Bhat K, Lawler S, Reis RM. Moreno DA, et al. Ther Adv Med Oncol. 2022 Dec 21;14:17588359221127678. doi: 10.1177/17588359221127678. eCollection 2022. Ther Adv Med Oncol. 2022. PMID: 36579028 Free PMC article.
Gene expression profile was assessed using the Pan-Cancer Immune Profiling Panel (Nanostring Technologies, Inc., Seattle, WA, USA). Data analysis was performed using nSolverSoftware and validated in The Cancer Genome Atlas. ...Two different prognostic groups were fo …
Gene expression profile was assessed using the Pan-Cancer Immune Profiling Panel (Nanostring Technologies, Inc., Seattle, WA, USA). D …
150 results