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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 1
1992 1
1993 4
1994 11
1995 3
1996 11
1997 9
1998 5
1999 18
2000 19
2001 25
2002 25
2003 28
2004 22
2005 34
2006 30
2007 38
2008 24
2009 23
2010 23
2011 33
2012 24
2013 44
2014 37
2015 29
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2023 17
2024 5

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688 results

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Page 1
Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways.
Zhou D, Huang C, Lin Z, Zhan S, Kong L, Fang C, Li J. Zhou D, et al. Cell Signal. 2014 Feb;26(2):192-7. doi: 10.1016/j.cellsig.2013.11.004. Epub 2013 Nov 9. Cell Signal. 2014. PMID: 24219909 Review.
Two major macrophage subpopulations with different functions which represent extreme of a continuum in a universe of activation states, including classically activated/inflammatory (M1) and alternatively activated/regenerative (M2) macrophages, have long been recogn …
Two major macrophage subpopulations with different functions which represent extreme of a continuum in a universe of activation state …
Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance.
Sheu KM, Hoffmann A. Sheu KM, et al. Annu Rev Immunol. 2022 Apr 26;40:295-321. doi: 10.1146/annurev-immunol-101320-031555. Annu Rev Immunol. 2022. PMID: 35471841 Free PMC article. Review.
Macrophages are distributed throughout the body-they circulate in the blood, line the mucosal membranes, reside within organs, and survey the connective tissue. ...When these hallmark properties are diminished, the macrophage's biological functions are impair
Macrophages are distributed throughout the body-they circulate in the blood, line the mucosal membranes, reside within organs, and su
Sublytic C5b-9 Induces CCL3/4 Production and Macrophage Accumulation in Thy-1N Rats via PKC-alpha/p65/IRF-8 Axis.
Wang W, Qian B, Zhao C, Peng M, Liu L, Xie M, Peng N, He Q, Ying S, Zhu Y, Wang T, Hu D, Zhao D, Zhang J, Wang Y, Qiu W. Wang W, et al. Int J Biol Sci. 2022 May 1;18(8):3178-3193. doi: 10.7150/ijbs.69652. eCollection 2022. Int J Biol Sci. 2022. PMID: 35637950 Free PMC article.
Further experiments in vitro revealed that the phosphorylated PKC-alpha (p-PKC-alpha) could promote p65 phosphorylation, and then p-p65 enhanced IRF-8 expression through binding to IRF-8 promotor (-591 ~ -582 nt and -299 ~ -290 nt). ...The underlying mechanism invol …
Further experiments in vitro revealed that the phosphorylated PKC-alpha (p-PKC-alpha) could promote p65 phosphorylation, and then p-p65 enha …
Macrophage membrane-functionalized nanofibrous mats and their immunomodulatory effects on macrophage polarization.
Nakkala JR, Duan Y, Ding J, Muhammad W, Zhang D, Mao Z, Ouyang H, Gao C. Nakkala JR, et al. Acta Biomater. 2022 Mar 15;141:24-38. doi: 10.1016/j.actbio.2021.12.026. Epub 2021 Dec 25. Acta Biomater. 2022. PMID: 34958971
In this study, macrophage membranes of different phenotypes (macrophages (M0), classically activated macrophages (M1) and alternatively activated macrophages (M2)) were coated onto poly-epsilon-caprolactone (PCL) nanofibers to acquire exterior surface …
In this study, macrophage membranes of different phenotypes (macrophages (M0), classically activated macrophages (M1) a …
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
Yang T, Wang R, Liu H, Wang L, Li J, Wu S, Chen X, Yang X, Zhao Y. Yang T, et al. Life Sci. 2021 Feb 1;266:118903. doi: 10.1016/j.lfs.2020.118903. Epub 2020 Dec 16. Life Sci. 2021. PMID: 33340526
The mRNA expression of M1-polarized Mphis, including TNF-alpha, NOS2, CCR7, and IRF-8, were suppressed by BBR administration and the mRNA expression of M2-polarized Mphis, including IL-4, STAT6, IL-10 and Chil3, were increased by BBR intervention. ...
The mRNA expression of M1-polarized Mphis, including TNF-alpha, NOS2, CCR7, and IRF-8, were suppressed by BBR administration and the …
The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2.
Chistiakov DA, Myasoedova VA, Revin VV, Orekhov AN, Bobryshev YV. Chistiakov DA, et al. Immunobiology. 2018 Jan;223(1):101-111. doi: 10.1016/j.imbio.2017.10.005. Epub 2017 Oct 5. Immunobiology. 2018. PMID: 29032836 Review.
Of 9 IRFs, at least 3 (IRF-1, IRF-5, and IRF-8) are involved in the commitment of proinflammatory M1 whereas IRF-3 and IRF-4 control M2 polarization. The role of IRF-2 is context-dependent. The IRF impact on macrophage pheno …
Of 9 IRFs, at least 3 (IRF-1, IRF-5, and IRF-8) are involved in the commitment of proinflammatory M1 whereas IRF
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Yamamoto M, et al. Science. 2003 Aug 1;301(5633):640-3. doi: 10.1126/science.1087262. Epub 2003 Jul 10. Science. 2003. PMID: 12855817
TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3. Furthermore, inflammatory cytokine production in response to the TLR4 ligand, but not to other TLR ligands, was severely impaired in TRIF-deficient macroph
TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3. Furthermore, infla …
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis.
Hoffner O'Connor M, Berglind A, Kennedy Ng MM, Keith BP, Lynch ZJ, Schaner MR, Steinbach EC, Herzog J, Trad OK, Jeck WR, Arthur JC, Simon JM, Sartor RB, Furey TS, Sheikh SZ. Hoffner O'Connor M, et al. Front Immunol. 2022 Mar 24;13:856966. doi: 10.3389/fimmu.2022.856966. eCollection 2022. Front Immunol. 2022. PMID: 35401533 Free PMC article.
INTRODUCTION: In colitis, macrophage functionality is altered compared to normal homeostatic conditions. ...CONCLUSION: We identified the mechanism of action associated with a new class of compounds that may mitigate aberrant macrophage responses to bacteria in coli …
INTRODUCTION: In colitis, macrophage functionality is altered compared to normal homeostatic conditions. ...CONCLUSION: We identified …
Treatment with TNF-alpha inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.
Lin SH, Chuang HY, Ho JC, Lee CH, Hsiao CC. Lin SH, et al. J Dermatol Sci. 2018 Sep;91(3):276-284. doi: 10.1016/j.jdermsci.2018.05.009. Epub 2018 May 29. J Dermatol Sci. 2018. PMID: 29914850
BACKGROUND: Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-alpha inhibitors. TNF-alpha is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. ...TNF-alpha blockage inhibits M1 po …
BACKGROUND: Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-alpha inhibitors. TNF-alpha is mainly produced by …
CD34+ derived macrophage and dendritic cells display differential responses to paraquat.
Fransen LFH, Leonard MO. Fransen LFH, et al. Toxicol In Vitro. 2021 Sep;75:105198. doi: 10.1016/j.tiv.2021.105198. Epub 2021 Jun 9. Toxicol In Vitro. 2021. PMID: 34097952 Free PMC article.
To explore this further, primary cultures of human CD34+ stem cell derived macrophages (MC(cd34)) and dendritic cells (DC(cd34)) were established and characterised using RNA-Seq profiling. ...Interestingly, PQ induced unfolded protein response (UPR), p53, Irf and DC …
To explore this further, primary cultures of human CD34+ stem cell derived macrophages (MC(cd34)) and dendritic cells (DC(cd34)) were …
688 results