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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 1
1992 1
1993 4
1994 11
1995 3
1996 11
1997 9
1998 5
1999 18
2000 19
2001 25
2002 25
2003 28
2004 22
2005 34
2006 30
2007 38
2008 24
2009 23
2010 23
2011 33
2012 24
2013 44
2014 37
2015 29
2016 26
2017 34
2018 27
2019 34
2020 34
2021 30
2022 17
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661 results
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Page 1
Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways.
Zhou D, Huang C, Lin Z, Zhan S, Kong L, Fang C, Li J. Zhou D, et al. Cell Signal. 2014 Feb;26(2):192-7. doi: 10.1016/j.cellsig.2013.11.004. Epub 2013 Nov 9. Cell Signal. 2014. PMID: 24219909 Review.
Two major macrophage subpopulations with different functions which represent extreme of a continuum in a universe of activation states, including classically activated/inflammatory (M1) and alternatively activated/regenerative (M2) macrophages, have long been recogn …
Two major macrophage subpopulations with different functions which represent extreme of a continuum in a universe of activation state …
The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2.
Chistiakov DA, Myasoedova VA, Revin VV, Orekhov AN, Bobryshev YV. Chistiakov DA, et al. Immunobiology. 2018 Jan;223(1):101-111. doi: 10.1016/j.imbio.2017.10.005. Epub 2017 Oct 5. Immunobiology. 2018. PMID: 29032836 Review.
Of 9 IRFs, at least 3 (IRF-1, IRF-5, and IRF-8) are involved in the commitment of proinflammatory M1 whereas IRF-3 and IRF-4 control M2 polarization. The role of IRF-2 is context-dependent. The IRF impact on macrophage pheno …
Of 9 IRFs, at least 3 (IRF-1, IRF-5, and IRF-8) are involved in the commitment of proinflammatory M1 whereas IRF
The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy.
Zhang Y, Ma L, Hu X, Ji J, Mor G, Liao A. Zhang Y, et al. Hum Reprod. 2019 Jan 1;34(1):25-36. doi: 10.1093/humrep/dey347. Hum Reprod. 2019. PMID: 30500923
STUDY QUESTION: What is the role of the programmed cell death-1 (PD-1)/PD-1 ligand-1 (PD-L1) axis in macrophage polarization during early pregnancy? SUMMARY ANSWER: PD-1 signaling is a major regulator of macrophage differentiation and function, and it is critical fo …
STUDY QUESTION: What is the role of the programmed cell death-1 (PD-1)/PD-1 ligand-1 (PD-L1) axis in macrophage polarization during e …
IRF family of transcription factors as regulators of host defense.
Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. Taniguchi T, et al. Annu Rev Immunol. 2001;19:623-55. doi: 10.1146/annurev.immunol.19.1.623. Annu Rev Immunol. 2001. PMID: 11244049 Review.
Following the initial identification of two structurally related members, IRF-1 and IRF-2, seven additional members have now been reported. ...Indeed, IRF-1 selectively modulates different sets of genes, depending on the cell type and/or the nature of cellula …
Following the initial identification of two structurally related members, IRF-1 and IRF-2, seven additional members have now b …
CD34+ derived macrophage and dendritic cells display differential responses to paraquat.
Fransen LFH, Leonard MO. Fransen LFH, et al. Toxicol In Vitro. 2021 Sep;75:105198. doi: 10.1016/j.tiv.2021.105198. Epub 2021 Jun 9. Toxicol In Vitro. 2021. PMID: 34097952 Free PMC article.
To explore this further, primary cultures of human CD34+ stem cell derived macrophages (MC(cd34)) and dendritic cells (DC(cd34)) were established and characterised using RNA-Seq profiling. ...Interestingly, PQ induced unfolded protein response (UPR), p53, Irf and DC …
To explore this further, primary cultures of human CD34+ stem cell derived macrophages (MC(cd34)) and dendritic cells (DC(cd34)) were …
IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Kayagaki N, Lee BL, Stowe IB, Kornfeld OS, O'Rourke K, Mirrashidi KM, Haley B, Watanabe C, Roose-Girma M, Modrusan Z, Kummerfeld S, Reja R, Zhang Y, Cho V, Andrews TD, Morris LX, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Sci Signal. 2019 May 21;12(582):eaax4917. doi: 10.1126/scisignal.aax4917. Sci Signal. 2019. PMID: 31113851
Here, we showed that IRF2, a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the transcriptional activation of GSDMD. ...GSDMD expression was substantially attenuated in IRF2-deficient macrophages, endothelial cell …
Here, we showed that IRF2, a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the …
IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury.
Chen M, Wen X, Gao Y, Liu B, Zhong C, Nie J, Liang H. Chen M, et al. Int Immunopharmacol. 2021 Nov;100:108142. doi: 10.1016/j.intimp.2021.108142. Epub 2021 Sep 20. Int Immunopharmacol. 2021. PMID: 34555644
In addition, IRF-4 ablation impaired F4/80(+) macrophages and CD3(+) T lymphocytes infiltration into the FA-injured kidneys. ...Moreover, IRF-4 disruption inhibited macrophages to myofibroblasts differentiation in the kidneys in response to FA stimuli. …
In addition, IRF-4 ablation impaired F4/80(+) macrophages and CD3(+) T lymphocytes infiltration into the FA-injured kidneys. . …
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
Yang T, Wang R, Liu H, Wang L, Li J, Wu S, Chen X, Yang X, Zhao Y. Yang T, et al. Life Sci. 2021 Feb 1;266:118903. doi: 10.1016/j.lfs.2020.118903. Epub 2020 Dec 16. Life Sci. 2021. PMID: 33340526
The mRNA expression of M1-polarized Mphis, including TNF-alpha, NOS2, CCR7, and IRF-8, were suppressed by BBR administration and the mRNA expression of M2-polarized Mphis, including IL-4, STAT6, IL-10 and Chil3, were increased by BBR intervention. ...
The mRNA expression of M1-polarized Mphis, including TNF-alpha, NOS2, CCR7, and IRF-8, were suppressed by BBR administration and the …
Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.
Lin SH, Chuang HY, Ho JC, Lee CH, Hsiao CC. Lin SH, et al. J Dermatol Sci. 2018 Sep;91(3):276-284. doi: 10.1016/j.jdermsci.2018.05.009. Epub 2018 May 29. J Dermatol Sci. 2018. PMID: 29914850
BACKGROUND: Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-alpha inhibitors. TNF-alpha is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. ...TNF-alpha blockage inhibits M1 po …
BACKGROUND: Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-alpha inhibitors. TNF-alpha is mainly produced by …
Phagocytosis and immune response studies of Macrophage-Nanodiamond Interactions in vitro and in vivo.
Huang KJ, Lee CY, Lin YC, Lin CY, Perevedentseva E, Hung SF, Cheng CL. Huang KJ, et al. J Biophotonics. 2017 Oct;10(10):1315-1326. doi: 10.1002/jbio.201600202. Epub 2017 Jan 9. J Biophotonics. 2017. PMID: 28067461
The applications of nanodiamond as drug delivery and bio-imaging can require the relinquishing ND-drug conjugate via blood flow, where interaction with immune cells may occur. In this work, we investigated the ND penetration in macrophage and the immune response using the …
The applications of nanodiamond as drug delivery and bio-imaging can require the relinquishing ND-drug conjugate via blood flow, where inter …
661 results