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Year Number of Results
1990 1
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756 results

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Page 1
Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance.
Sheu KM, Hoffmann A. Sheu KM, et al. Annu Rev Immunol. 2022 Apr 26;40:295-321. doi: 10.1146/annurev-immunol-101320-031555. Annu Rev Immunol. 2022. PMID: 35471841 Free PMC article. Review.
Macrophages are distributed throughout the body-they circulate in the blood, line the mucosal membranes, reside within organs, and survey the connective tissue. ...When these hallmark properties are diminished, the macrophage's biological functions are impair …
Macrophages are distributed throughout the body-they circulate in the blood, line the mucosal membranes, reside within organs, and su …
Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways.
Zhou D, Huang C, Lin Z, Zhan S, Kong L, Fang C, Li J. Zhou D, et al. Cell Signal. 2014 Feb;26(2):192-7. doi: 10.1016/j.cellsig.2013.11.004. Epub 2013 Nov 9. Cell Signal. 2014. PMID: 24219909 Review.
Two major macrophage subpopulations with different functions which represent extreme of a continuum in a universe of activation states, including classically activated/inflammatory (M1) and alternatively activated/regenerative (M2) macrophages, have long been recogn …
Two major macrophage subpopulations with different functions which represent extreme of a continuum in a universe of activation state …
Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus.
Zhang S, Zhong R, Zhou M, Li K, Lv H, Wang H, Xu Y, Liu D, Ma Q, Chen L, Zhang H. Zhang S, et al. Adv Sci (Weinh). 2025 Jun;12(21):e2415948. doi: 10.1002/advs.202415948. Epub 2025 Apr 8. Adv Sci (Weinh). 2025. PMID: 40200426 Free PMC article.
This study revealed that baicalin alleviates bacterial intestinal inflammation through regulating macrophage polarization and increasing Lactobacillus amylovorus abundance in colon. Specifically, transcriptomic analysis showed that baicalin restored Escherichia coli-induce …
This study revealed that baicalin alleviates bacterial intestinal inflammation through regulating macrophage polarization and increas …
ZBP1 senses Brucella abortus DNA triggering type I interferon signaling pathway and unfolded protein response activation.
Gomes MTR, Guimarães ES, Oliveira SC. Gomes MTR, et al. Front Immunol. 2025 Jan 9;15:1511949. doi: 10.3389/fimmu.2024.1511949. eCollection 2024. Front Immunol. 2025. PMID: 39850894 Free PMC article.
Furthermore, ZBP1 is involved in type I IFN signaling inducing IRF-1 expression. Additionally, ZBP1 also contributes to Unfolded Protein Response (UPR) activation during infection. However, ZBP1 does not influence the production of proinflammatory mediators, inflammasome a …
Furthermore, ZBP1 is involved in type I IFN signaling inducing IRF-1 expression. Additionally, ZBP1 also contributes to Unfolded Prot …
Interplay Between KLF4, STAT, IRF, and NF-kappaB in VSMC and Macrophage Plasticity During Vascular Inflammation and Atherosclerosis.
Lopacinska N, Wesoly J, Bluyssen HAR. Lopacinska N, et al. Int J Mol Sci. 2025 Oct 20;26(20):10205. doi: 10.3390/ijms262010205. Int J Mol Sci. 2025. PMID: 41155497 Free PMC article. Review.
Atherosclerosis is characterized by atherosclerotic plaque formation in large and medium vessels, mediated by endothelial cell (EC) dysfunction, altered contractility of Vascular Smooth Muscle Cells (VSMCs) and recruitment of blood leukocytes to the injured vascular endothelium. …
Atherosclerosis is characterized by atherosclerotic plaque formation in large and medium vessels, mediated by endothelial cell (EC) dysfunct …
Sublytic C5b-9 Induces CCL3/4 Production and Macrophage Accumulation in Thy-1N Rats via PKC-alpha/p65/IRF-8 Axis.
Wang W, Qian B, Zhao C, Peng M, Liu L, Xie M, Peng N, He Q, Ying S, Zhu Y, Wang T, Hu D, Zhao D, Zhang J, Wang Y, Qiu W. Wang W, et al. Int J Biol Sci. 2022 May 1;18(8):3178-3193. doi: 10.7150/ijbs.69652. eCollection 2022. Int J Biol Sci. 2022. PMID: 35637950 Free PMC article.
Further experiments in vitro revealed that the phosphorylated PKC-alpha (p-PKC-alpha) could promote p65 phosphorylation, and then p-p65 enhanced IRF-8 expression through binding to IRF-8 promotor (-591 ~ -582 nt and -299 ~ -290 nt). ...The underlying mechanism invol …
Further experiments in vitro revealed that the phosphorylated PKC-alpha (p-PKC-alpha) could promote p65 phosphorylation, and then p-p65 enha …
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis.
Peng Y, Yang Y, Li Y, Shi T, Xu N, Liu R, Luan Y, Yao Y, Yin C. Peng Y, et al. Cell Mol Biol Lett. 2024 Apr 27;29(1):61. doi: 10.1186/s11658-024-00575-9. Cell Mol Biol Lett. 2024. PMID: 38671352 Free PMC article.
BACKGROUND: Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbate the cellular immune suppression during the …
BACKGROUND: Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously …
Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis.
Zhang X, Ling C, Xiong Z, Gong T, Luo S, Liu X, Zhang L, Liao C, Lu Y, Huang X, Zhou W, Zhou S, Liu Y, Tang J. Zhang X, et al. Cell Rep. 2024 Dec 24;43(12):115060. doi: 10.1016/j.celrep.2024.115060. Epub 2024 Dec 13. Cell Rep. 2024. PMID: 39673708 Free article.
In endotoxemia and sepsis models, reduced SIRT5 levels in macrophages increased TBK1 succinylation, inhibiting its binding to IRF3 and TRAF2 and suppressing the inflammatory response. ...These findings reveal a novel mechanism by which SIRT5 modulates TBK1 activity and …
In endotoxemia and sepsis models, reduced SIRT5 levels in macrophages increased TBK1 succinylation, inhibiting its binding to IRF3 an …
Green (Ulva fenestrata) and Brown (Saccharina latissima) Macroalgae Similarly Modulate Inflammatory Signaling by Activating NF-kappaB and Dampening IRF in Human Macrophage-Like Cells.
Mildenberger J, Rebours C. Mildenberger J, et al. J Immunol Res. 2024 May 17;2024:8121284. doi: 10.1155/2024/8121284. eCollection 2024. J Immunol Res. 2024. PMID: 38799117 Free PMC article.
Effects of the macroalgae extracts were assessed on transcription factor activity of NF-kappaB and IRF as well as secretion and/or expression of the cytokines TNF-alpha and IFN-beta and chemokines IL-8 and CXCL10. ...On the other hand, pretreatment with macroalgae extracts …
Effects of the macroalgae extracts were assessed on transcription factor activity of NF-kappaB and IRF as well as secretion and/or ex …
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Yamamoto M, et al. Science. 2003 Aug 1;301(5633):640-3. doi: 10.1126/science.1087262. Epub 2003 Jul 10. Science. 2003. PMID: 12855817
TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3. Furthermore, inflammatory cytokine production in response to the TLR4 ligand, but not to other TLR ligands, was severely impaired in TRIF-deficient macroph …
TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3. Furthermore, infla …
756 results