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Year Number of Results
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Page 1
Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells.
Guo Y, Gu R, Gan D, Hu F, Li G, Xu G. Guo Y, et al. Cell Commun Signal. 2020 Oct 28;18(1):172. doi: 10.1186/s12964-020-00637-3. Cell Commun Signal. 2020. PMID: 33115500 Free PMC article.
BACKGROUND: Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious inflammation. Retinal microvascular endothel …
BACKGROUND: Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in ma …
Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury.
Chen X, Qi D, Fan S, He Y, Jing H, Wang D. Chen X, et al. Clin Sci (Lond). 2023 Mar 15;137(5):367-383. doi: 10.1042/CS20220876. Clin Sci (Lond). 2023. PMID: 36857175 Free PMC article.
However, little is known about the molecular mechanism that underpin endothelial cell regeneration in ARDS. METHODS: R-based bioinformatics tools were used to analyze microarray-derived transcription profiles in human lung microvascular endothelial …
However, little is known about the molecular mechanism that underpin endothelial cell regeneration in ARDS. METHODS: R-based b …
Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii.
Colonne PM, Sahni A, Sahni SK. Colonne PM, et al. J Med Microbiol. 2013 Jul;62(Pt 7):968-979. doi: 10.1099/jmm.0.054502-0. Epub 2013 Apr 4. J Med Microbiol. 2013. PMID: 23558133 Free PMC article.
Our recent studies reveal that human microvascular endothelial cells (HMECs) infected with R. conorii also launch 'antiviral' host defence mechanisms typically governed by type I interferons. ...A number of IFN-stimulated genes, including ISG15, OAS1, MX1, …
Our recent studies reveal that human microvascular endothelial cells (HMECs) infected with R. conorii also launch 'anti …
Bone Marrow Mesenchymal Stem Cells Release miR-378a-5p-Carried Extracellular Vesicles to Alleviate Rheumatoid Arthritis.
Zhang Y, Jiao Z, Wang S. Zhang Y, et al. J Innate Immun. 2023;15(1):893-910. doi: 10.1159/000534830. Epub 2023 Nov 3. J Innate Immun. 2023. PMID: 37926093 Free PMC article.
This study investigates whether bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) can affect rheumatoid arthritis (RA) by delivering microRNA (miR)-378a-5p to regulate the interferon regulatory factor 1/signal transducer and transcription 1 ( …
This study investigates whether bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) can affect rheumatoid a …
Hantavirus infection induces the expression of RANTES and IP-10 without causing increased permeability in human lung microvascular endothelial cells.
Sundstrom JB, McMullan LK, Spiropoulou CF, Hooper WC, Ansari AA, Peters CJ, Rollin PE. Sundstrom JB, et al. J Virol. 2001 Jul;75(13):6070-85. doi: 10.1128/JVI.75.13.6070-6085.2001. J Virol. 2001. PMID: 11390609 Free PMC article.
Sin Nombre virus (SNV) and Hantaan virus (HTN) infect endothelial cells and are associated with different patterns of increased vascular permeability during human disease. ...In this study, the ability of hantavirus to directly induce activation of human lung mic …
Sin Nombre virus (SNV) and Hantaan virus (HTN) infect endothelial cells and are associated with different patterns of increase …
Early angiogenic response to shock waves in a three-dimensional model of human microvascular endothelial cell culture (HMEC-1).
Sansone V, D' Agostino MC, Bonora C, Sizzano F, De Girolamo L, Romeo P. Sansone V, et al. J Biol Regul Homeost Agents. 2012 Jan-Mar;26(1):29-37. J Biol Regul Homeost Agents. 2012. PMID: 22475095
To test this hypothesis, a three-dimensional (3D) culture model on Matrigel was developed employing a human microvascular endothelial cell line (HMEC-1) which was stimulated with low energy soft- focused SW generated by an SW lithotripter. ...Our preliminary …
To test this hypothesis, a three-dimensional (3D) culture model on Matrigel was developed employing a human microvascular endothel …
Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-beta autocrine signaling to promote monocyte recruitment.
Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Venkatesh D, et al. Immunity. 2013 May 23;38(5):1025-37. doi: 10.1016/j.immuni.2013.01.012. Epub 2013 Apr 25. Immunity. 2013. PMID: 23623383 Free PMC article.
Endothelial-dependent mechanisms of mononuclear cell influx are not well understood. We showed that acute stimulation of murine microvascular endothelial cells expressing the tumor necrosis factor receptors TNFR1 and TNFR2 with the soluble cytok …
Endothelial-dependent mechanisms of mononuclear cell influx are not well understood. We showed that acute stimulation of murin …
Microvascular endothelial cells of the bovine corpus luteum: a comparative examination of the estrous cycle and pregnancy.
Cherry JA, Hou X, Rueda BR, Davis JS, Townson DH. Cherry JA, et al. J Reprod Dev. 2008 Jun;54(3):183-91. doi: 10.1262/jrd.19182. Epub 2008 Feb 25. J Reprod Dev. 2008. PMID: 18296866 Free article.
Endothelial cells derived from the corpus luteum (CLENDOs) exhibit diverse characteristics presumably serving their wide-ranging roles in luteal function and fate. ...Lastly, extended exposure of CLENDOs of midcycle CL to cytokines induced cell death (~50% …
Endothelial cells derived from the corpus luteum (CLENDOs) exhibit diverse characteristics presumably serving their wide-rangi …
Innate Immune Dysfunction in Rosacea Promotes Photosensitivity and Vascular Adhesion Molecule Expression.
Kulkarni NN, Takahashi T, Sanford JA, Tong Y, Gombart AF, Hinds B, Cheng JY, Gallo RL. Kulkarni NN, et al. J Invest Dermatol. 2020 Mar;140(3):645-655.e6. doi: 10.1016/j.jid.2019.08.436. Epub 2019 Aug 29. J Invest Dermatol. 2020. PMID: 31472105 Free PMC article.
Sequencing of RNA from the endothelial cells uncovered the activation of Gene Ontology (GO) pathways relevant to the human disease, such as type I and II interferon signaling, cell-cell adhesion, leukocyte chemotaxis, and angiogenesis. Functional relev …
Sequencing of RNA from the endothelial cells uncovered the activation of Gene Ontology (GO) pathways relevant to the human dis …
IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease.
Perez F, Ruera CN, Miculan E, Carasi P, Dubois-Camacho K, Garbi L, Guzman L, Hermoso MA, Chirdo FG. Perez F, et al. Front Immunol. 2020 Oct 8;11:581445. doi: 10.3389/fimmu.2020.581445. eCollection 2020. Front Immunol. 2020. PMID: 33133101 Free PMC article.
Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelial cells. While localized in the nucleus acting as a gene regulator, it can be also released after injury, stress or inflammatory …
Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelia …
23 results