Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system.
Stem Cell Res. 2022 Jan;58:102627. doi: 10.1016/j.scr.2021.102627. Epub 2021 Dec 13.
Stem Cell Res. 2022.
PMID: 34929443
Free article.
Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular electrical repolarization gradient in the adult heart. Mutations in IRX5 have also been linked in humans to cardiac conduct …
Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular elec …