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Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system.
Canac R, Caillaud A, Cimarosti B, Girardeau A, Hamamy H, Reversade B, Bonnard C, Al Sayed ZR, David L, Poschmann J, Lemarchand P, Lamirault G, Gaborit N. Canac R, et al. Stem Cell Res. 2022 Jan;58:102627. doi: 10.1016/j.scr.2021.102627. Epub 2021 Dec 13. Stem Cell Res. 2022. PMID: 34929443 Free article.
Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular electrical repolarization gradient in the adult heart. Mutations in IRX5 have also been linked in humans to cardiac conduct …
Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular elec …
Dissection of the voltage-activated potassium outward currents in adult mouse ventricular myocytes: I(to,f), I(to,s), I(K,slow1), I(K,slow2), and I(ss).
Liu J, Kim KH, London B, Morales MJ, Backx PH. Liu J, et al. Basic Res Cardiol. 2011 Mar;106(2):189-204. doi: 10.1007/s00395-010-0134-z. Epub 2011 Jan 21. Basic Res Cardiol. 2011. PMID: 21253754
Voltage-activated outward K(+) currents (I (Kv)) are essential for cardiac repolarization and are major factors in the electrophysiological remodeling and arrhythmias seen in heart disease. Mouse models have been useful for understanding cardiac electrophysiology. ...In th …
Voltage-activated outward K(+) currents (I (Kv)) are essential for cardiac repolarization and are major factors in the electrophysiological …
lnc9141-a and -b Play a Different Role in Bovine Myoblast Proliferation, Apoptosis, and Differentiation.
Zhang M, Li B, Wang J, Zhang S, Li H, Ma L, Guo W, Lei C, Chen H, Lan X. Zhang M, et al. Mol Ther Nucleic Acids. 2019 Dec 6;18:554-566. doi: 10.1016/j.omtn.2019.09.013. Epub 2019 Sep 23. Mol Ther Nucleic Acids. 2019. PMID: 31675668 Free PMC article.
Previously, our transcriptome sequencing revealed that lnc9141 was differentially expressed in muscles of fetal bovine, calf, and adult bovine, which is considered to provide the basis for raising the muscle mass. In this study, we identified lnc9141 characters. lnc9141 ha …
Previously, our transcriptome sequencing revealed that lnc9141 was differentially expressed in muscles of fetal bovine, calf, and adult …
A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification.
Plaisance I, Chouvardas P, Sun Y, Nemir M, Aghagolzadeh P, Aminfar F, Shen S, Shim WJ, Rochais F, Johnson R, Palpant N, Pedrazzini T. Plaisance I, et al. Cardiovasc Res. 2023 Jun 13;119(6):1361-1376. doi: 10.1093/cvr/cvac191. Cardiovasc Res. 2023. PMID: 36537036 Free PMC article.
AIMS: The major cardiac cell types composing the adult heart arise from common multipotent precursor cells. Cardiac lineage decisions are guided by extrinsic and cell-autonomous factors, including recently discovered long noncoding RNAs (lncRNAs). ...They further de …
AIMS: The major cardiac cell types composing the adult heart arise from common multipotent precursor cells. Cardiac lineage de …
Sodium-Glucose Cotransporter 2 (SGLT2) as a Potential Biomarker and Target in Papillary Renal Cell Carcinoma.
Akkus E, Yekedüz E, Ürün Y. Akkus E, et al. Clin Genitourin Cancer. 2025 Apr;23(2):102314. doi: 10.1016/j.clgc.2025.102314. Epub 2025 Feb 6. Clin Genitourin Cancer. 2025. PMID: 40020263
SGLT2 inhibitors have markedly changed diabetes, heart failure, and kidney disease treatment, and are under investigation in cancer. However, the role of SGLT2 in papillary renal cell carcinoma (pRCC) is not known. ...High correlation (r > 0.6) with SGLT2 was observed i …
SGLT2 inhibitors have markedly changed diabetes, heart failure, and kidney disease treatment, and are under investigation in cancer. …
Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Bruneau BG, et al. Mol Cell Biol. 2001 Mar;21(5):1730-6. doi: 10.1128/MCB.21.5.1730-1736.2001. Mol Cell Biol. 2001. PMID: 11238910 Free PMC article.
In neonatal hearts, ventricular expression of atrial natriuretic factor and alpha-skeletal actin was markedly increased. Several weeks subsequent to these changes in embryonic and neonatal gene expression, increased expression of hypertrophic markers BNP and beta-myosin he …
In neonatal hearts, ventricular expression of atrial natriuretic factor and alpha-skeletal actin was markedly increased. Several week …
Regional variation in mRNA transcript abundance within the ventricular wall.
Rosati B, Grau F, McKinnon D. Rosati B, et al. J Mol Cell Cardiol. 2006 Feb;40(2):295-302. doi: 10.1016/j.yjmcc.2005.11.002. Epub 2006 Jan 18. J Mol Cell Cardiol. 2006. PMID: 16412459
One of these differentially expressed genes is the sodium channel gene Scn5a, which is expressed at higher levels in the endocardium than in the epicardium of rat heart. The transcription factor genes Irx3, Irx5 and Etv1 were found to be expressed in transmural grad …
One of these differentially expressed genes is the sodium channel gene Scn5a, which is expressed at higher levels in the endocardium than in …
Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.
Gaborit N, Varro A, Le Bouter S, Szuts V, Escande D, Nattel S, Demolombe S. Gaborit N, et al. J Mol Cell Cardiol. 2010 Oct;49(4):639-46. doi: 10.1016/j.yjmcc.2010.06.005. Epub 2010 Jun 21. J Mol Cell Cardiol. 2010. PMID: 20600101
In addition, they demonstrated an isoform switch in Na(+)/K(+)-ATPase, expressing more of the alpha1 and less of the alpha3 subunit than male hearts, along with increased expression of calmodulin-3. Iroquois transcription factors (IRX3, IRX5) were more strongly expr …
In addition, they demonstrated an isoform switch in Na(+)/K(+)-ATPase, expressing more of the alpha1 and less of the alpha3 subunit than mal …