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Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system.
Canac R, Caillaud A, Cimarosti B, Girardeau A, Hamamy H, Reversade B, Bonnard C, Al Sayed ZR, David L, Poschmann J, Lemarchand P, Lamirault G, Gaborit N. Canac R, et al. Stem Cell Res. 2022 Jan;58:102627. doi: 10.1016/j.scr.2021.102627. Epub 2021 Dec 13. Stem Cell Res. 2022. PMID: 34929443 Free article.
Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular electrical repolarization gradient in the adult heart. Mutations in IRX5 have also been linked in humans to cardiac conduct …
Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular elec …
lnc9141-a and -b Play a Different Role in Bovine Myoblast Proliferation, Apoptosis, and Differentiation.
Zhang M, Li B, Wang J, Zhang S, Li H, Ma L, Guo W, Lei C, Chen H, Lan X. Zhang M, et al. Mol Ther Nucleic Acids. 2019 Dec 6;18:554-566. doi: 10.1016/j.omtn.2019.09.013. Epub 2019 Sep 23. Mol Ther Nucleic Acids. 2019. PMID: 31675668 Free PMC article.
However, lnc9141-a or lnc9141-b interference was found to increase the number of S-phase myoblasts, and upregulate Cyclin D1 and Cyclin E expression. ...Meantime, high expression of lnc9141-b could decrease MyHC expression. In addition, the intergenic region between lnc914 …
However, lnc9141-a or lnc9141-b interference was found to increase the number of S-phase myoblasts, and upregulate Cyclin D1 and Cycl …
Dissection of the voltage-activated potassium outward currents in adult mouse ventricular myocytes: I(to,f), I(to,s), I(K,slow1), I(K,slow2), and I(ss).
Liu J, Kim KH, London B, Morales MJ, Backx PH. Liu J, et al. Basic Res Cardiol. 2011 Mar;106(2):189-204. doi: 10.1007/s00395-010-0134-z. Epub 2011 Jan 21. Basic Res Cardiol. 2011. PMID: 21253754
In this study, we developed a statistically rigorous method to uniquely quantify various I (Kv) in adult mouse ventricular myocytes, and concluded that tri-exponential functions combined with depolarizing pulses of duration greater than 20 s are essential to adequat …
In this study, we developed a statistically rigorous method to uniquely quantify various I (Kv) in adult mouse ventricular myocytes, …
Regional variation in mRNA transcript abundance within the ventricular wall.
Rosati B, Grau F, McKinnon D. Rosati B, et al. J Mol Cell Cardiol. 2006 Feb;40(2):295-302. doi: 10.1016/j.yjmcc.2005.11.002. Epub 2006 Jan 18. J Mol Cell Cardiol. 2006. PMID: 16412459
One of these differentially expressed genes is the sodium channel gene Scn5a, which is expressed at higher levels in the endocardium than in the epicardium of rat heart. The transcription factor genes Irx3, Irx5 and Etv1 were found to be expressed in transmural grad …
One of these differentially expressed genes is the sodium channel gene Scn5a, which is expressed at higher levels in the endocardium than in …
Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Bruneau BG, et al. Mol Cell Biol. 2001 Mar;21(5):1730-6. doi: 10.1128/MCB.21.5.1730-1736.2001. Mol Cell Biol. 2001. PMID: 11238910 Free PMC article.
In neonatal hearts, ventricular expression of atrial natriuretic factor and alpha-skeletal actin was markedly increased. Several weeks subsequent to these changes in embryonic and neonatal gene expression, increased expression of hypertrophic markers BNP and beta-myosin he …
In neonatal hearts, ventricular expression of atrial natriuretic factor and alpha-skeletal actin was markedly increased. Several week …
Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.
Gaborit N, Varro A, Le Bouter S, Szuts V, Escande D, Nattel S, Demolombe S. Gaborit N, et al. J Mol Cell Cardiol. 2010 Oct;49(4):639-46. doi: 10.1016/j.yjmcc.2010.06.005. Epub 2010 Jun 21. J Mol Cell Cardiol. 2010. PMID: 20600101
In addition, they demonstrated an isoform switch in Na(+)/K(+)-ATPase, expressing more of the alpha1 and less of the alpha3 subunit than male hearts, along with increased expression of calmodulin-3. Iroquois transcription factors (IRX3, IRX5) were more strongly expr …
In addition, they demonstrated an isoform switch in Na(+)/K(+)-ATPase, expressing more of the alpha1 and less of the alpha3 subunit than mal …