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The role of antibodies in small fiber neuropathy: a review of currently available evidence.
Morelli L, Serra L, Ricciardiello F, Gligora I, Donadio V, Caprini M, Liguori R, Giannoccaro MP. Morelli L, et al. Rev Neurosci. 2024 Jun 13;35(8):877-893. doi: 10.1515/revneuro-2024-0027. Print 2024 Dec 17. Rev Neurosci. 2024. PMID: 38865989 Review.
Small fiber neuropathy (SFN) is a peripheral nerve condition affecting thin myelinated Adelta and unmyelinated C-fibers, characterized by severe neuropathic pain and other sensory and autonomic symptoms. A variety of medical disorders can cause SFN; however, …
Small fiber neuropathy (SFN) is a peripheral nerve condition affecting thin myelinated Adelta and unmyelinated C-fibers …
Primary Sjogren syndrome-related peripheral neuropathy: A systematic review and meta-analysis.
Liampas A, Parperis K, Erotocritou MF, Nteveros A, Papadopoulou M, Moschovos C, Akil M, Coaccioli S, Hadjigeorgiou GM, Hadjivassiliou M, Zis P. Liampas A, et al. Eur J Neurol. 2023 Jan;30(1):255-265. doi: 10.1111/ene.15555. Epub 2022 Sep 23. Eur J Neurol. 2023. PMID: 36086910 Free PMC article.
BACKGROUND AND PURPOSE: Primary Sjogren syndrome (pSS) is a chronic, systemic, autoimmune disorder characterized by lymphocytic infiltrates of the exocrine organs, leading to sicca symptoms and parotid enlargement. pSS has been linked to various neurological manifestations …
BACKGROUND AND PURPOSE: Primary Sjogren syndrome (pSS) is a chronic, systemic, autoimmune disorder characterized by lymphocytic infil …
Updated consensus statement: Intravenous immunoglobulin in the treatment of neuromuscular disorders report of the AANEM ad hoc committee.
Tavee J, Brannagan TH 3rd, Lenihan MW, Muppidi S, Kellermeyer L, D Donofrio P; AANEM. Tavee J, et al. Muscle Nerve. 2023 Oct;68(4):356-374. doi: 10.1002/mus.27922. Epub 2023 Jul 11. Muscle Nerve. 2023. PMID: 37432872 Review.
Based on Class II evidence, IVIG is also recommended for Lambert-Eaton myasthenic syndrome and pediatric GBS. In contrast, based on Class I evidence, IVIG is not recommended for inclusion body myositis, post-polio syndrome, IgM paraproteinemic neuropathy and …
Based on Class II evidence, IVIG is also recommended for Lambert-Eaton myasthenic syndrome and pediatric GBS. In contrast, based on C …
The effect of high-dose long-term therapy of intravenous immunoglobulins in autoimmune autonomic and sensory small fiber neuropathy: a retrospective open-label controlled study.
Novak P, Witte A, Marciano SP, Felsenstein D, Ngo L. Novak P, et al. Sci Rep. 2025 Dec 20;16(1):3151. doi: 10.1038/s41598-025-33059-7. Sci Rep. 2025. PMID: 41422333 Free PMC article.
Intravenous Immunoglobulins (IVIG) are used to treat autoimmune autonomic and sensory small fiber neuropathy (ASFN). ...Patients were treated with IVIG until their condition improved and reached a plateau. Linear models cont …
Intravenous Immunoglobulins (IVIG) are used to treat autoimmune autonomic and sensory small fiber …
How We Treat Autoimmune Small Fiber Polyneuropathy with Immunoglobulin Therapy.
Schofield JR, Chemali KR. Schofield JR, et al. Eur Neurol. 2018;80(5-6):304-310. doi: 10.1159/000498858. Epub 2019 Mar 19. Eur Neurol. 2018. PMID: 30889595 Review.
Immunoglobulin therapy has been used increasingly with significant efficacy in the treatment of patients with disabling autoimmune forms of dysautonomia, which are most often small fiber (autonomic and/or sensory) polyneuropathies. ...We discuss our combined …
Immunoglobulin therapy has been used increasingly with significant efficacy in the treatment of patients with disabling autoimmune fo …
A double-blind placebo-controlled pilot study of immunoglobulin for small fiber neuropathy associated with TS-HDS and FGFR-3 autoantibodies.
Gibbons CH, Rajan S, Senechal K, Hendry E, McCallister B, Levine TD. Gibbons CH, et al. Muscle Nerve. 2023 May;67(5):363-370. doi: 10.1002/mus.27745. Epub 2022 Nov 29. Muscle Nerve. 2023. PMID: 36367813 Clinical Trial.
INTRODUCTION/AIMS: Small fiber neuropathies (SFN) have been associated with two autoantibodies, trisulfated heparin disaccharide (TS-HDS) and fibroblast growth factor receptor 3 (FGFR-3), and intravenous immune globulin (IVIG) has been suggested as a p …
INTRODUCTION/AIMS: Small fiber neuropathies (SFN) have been associated with two autoantibodies, trisulfated heparin disacchari …
Intravenouse immunoglobuline in dysautonomia.
Gavrilova N, Kamaeva E, Ignatova M, Ryabkova V, Lukashenko M, Soprun L, Churilov LP, Shoenfeld Y. Gavrilova N, et al. Clin Immunol. 2022 Jul;240:109039. doi: 10.1016/j.clim.2022.109039. Epub 2022 May 13. Clin Immunol. 2022. PMID: 35569781 Review.
Nowadays intravenous immunoglobulin (IVIg) treatment is considered to play a promising role in the autoimmune disease therapy. Despite its significant beneficial effects, the precise mechanism of action needs further studies, as well as recommended dosage in …
Nowadays intravenous immunoglobulin (IVIg) treatment is considered to play a promising role in the autoimmune disease t …
A role for pathogenic autoantibodies in small fiber neuropathy?
Daifallah O, Farah A, Dawes JM. Daifallah O, et al. Front Mol Neurosci. 2023 Sep 20;16:1254854. doi: 10.3389/fnmol.2023.1254854. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37799730 Free PMC article. Review.
For example, passive transfer of CASPR2 autoantibodies from patients cause increased pain sensitivity and enhanced sensory neuron excitability in mice confirming pathogenicity and demonstrating that patient autoantibodies are a mechanism to cause neuropathic pain. Small …
For example, passive transfer of CASPR2 autoantibodies from patients cause increased pain sensitivity and enhanced sensory neuron excitabili …
Autoimmune Small Fiber Neuropathy Associated With Ehlers-Danlos Syndrome Treated With Intravenous Immunoglobulins.
Cook MK, Jordan M. Cook MK, et al. J Clin Neuromuscul Dis. 2021 Mar 1;22(3):160-163. doi: 10.1097/CND.0000000000000341. J Clin Neuromuscul Dis. 2021. PMID: 33596000
Patients with Ehlers-Danlos syndrome (EDS) have many associated symptoms of unclear cause, most recently suggested to be due to small fiber neuropathy (SFN). Small fiber neuropathies are sorely underestimated and with minimal treatment options. …
Patients with Ehlers-Danlos syndrome (EDS) have many associated symptoms of unclear cause, most recently suggested to be due to small …
Small Fiber Neuropathy Triggered by COVID-19 Vaccination: Association with FGFR3 Autoantibodies and Improvement during Intravenous Immunoglobulin Treatment.
Mastropaolo M, Hasbani MJ. Mastropaolo M, et al. Case Rep Neurol. 2023 Jan 27;15(1):6-10. doi: 10.1159/000528566. eCollection 2023 Jan-Dec. Case Rep Neurol. 2023. PMID: 36742446 Free PMC article.
Further, one large case supports that the COVID-19 vaccine has been reported to result in small fiber neuropathy. We report a case of a patient with confirmed small fiber neuropathy post-COVID-19 vaccination with positive FGFR3 antibodies …
Further, one large case supports that the COVID-19 vaccine has been reported to result in small fiber neuropathy. We re …
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