Natural occurring 2-(2-phenylethyl) chromones, structure elucidation and biological activities

Nat Prod Res. 2015;29(16):1489-520. doi: 10.1080/14786419.2014.991323. Epub 2014 Dec 20.

Abstract

2-(2-Phenylethyl) chromone (PEC), an uncommon class of chromones, possesses a phenylethyl substituent at the C2 position. They have been isolated from a few plant species. They have promising biological activities such as neuro-protective, cytotoxic, acetylcholinesterase inhibitory, antibacterial and anti-inflammatory. This review focuses on the naturally occurring PEC derivatives, their sources, physical and spectral data, as well as biological activities.

Keywords: 2-(2-phenylethyl) chromones; biological activities; physical data; plant source; spectral data.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Inflammatory Agents / chemistry
  • Cell Line
  • Cell Line, Tumor
  • Cholinesterase Inhibitors / chemistry
  • Chromones / chemistry*
  • Cucurbitaceae / chemistry
  • Drugs, Chinese Herbal / chemistry*
  • Flavonoids / chemistry*
  • Humans
  • Mice
  • Molecular Structure
  • Neuroprotective Agents / chemistry
  • Thymelaeaceae / chemistry

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Cholinesterase Inhibitors
  • Chromones
  • Drugs, Chinese Herbal
  • Flavonoids
  • Neuroprotective Agents
  • 2-(2-phenylethyl)chromone