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Identification of a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells.
Rossi D, Pedrali A, Urbano M, Gaggeri R, Serra M, Fernández L, Fernández M, Caballero J, Ronsisvalle S, Prezzavento O, Schepmann D, Wuensch B, Peviani M, Curti D, Azzolina O, Collina S. Rossi D, et al. Bioorg Med Chem. 2011 Nov 1;19(21):6210-24. doi: 10.1016/j.bmc.2011.09.016. Epub 2011 Sep 14. Bioorg Med Chem. 2011. PMID: 21967807
Moreover in PC12 cells (R,S)-33 promoted the nerve growth factor (NGF)-induced neurite outgrowth and elongation. Co-administration of the selective sigma(1) receptor antagonist BD-1063 totally counteracted this effect …
Moreover in PC12 cells (R,S)-33 promoted the nerve growth factor (NGF)-induced neurite outgrowt …
Identification of RC-33 as a potent and selective sigma1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-scale synthesis, physicochemical characterization and in vitro metabolic stability.
Rossi D, Marra A, Picconi P, Serra M, Catenacci L, Sorrenti M, Laurini E, Fermeglia M, Pricl S, Brambilla S, Almirante N, Peviani M, Curti D, Collina S. Rossi D, et al. Bioorg Med Chem. 2013 May 1;21(9):2577-86. doi: 10.1016/j.bmc.2013.02.029. Epub 2013 Feb 26. Bioorg Med Chem. 2013. PMID: 23498917
In the last years our research group has conducted extensive studies aimed at discovering novel sigma1 ligands and we recently selected (R/S)-RC-33 as a novel potent and selective sigma1 receptor agonist. As continuation of …
In the last years our research group has conducted extensive studies aimed at discovering novel sigma1 ligands and we recently sel …
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