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Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis.
Li J, Li YR, Glessner JT, Yang J, March ME, Kao C, Vaccaro CN, Bradfield JP, Li J, Mentch FD, Qu HQ, Qi X, Chang X, Hou C, Abrams DJ, Qiu H, Wei Z, Connolly JJ, Wang F, Snyder J, Flatø B, Thompson SD, Langefeld CD, Lie BA, Munro JE, Wise C, Sleiman PMA, Hakonarson H. Li J, et al. Arthritis Rheumatol. 2022 Aug;74(8):1420-1429. doi: 10.1002/art.42129. Epub 2022 Jul 15. Arthritis Rheumatol. 2022. PMID: 35347896 Free PMC article.
RESULTS: In addition to the major histocompatibility complex locus, we identified 15 genome-wide significant loci shared between at least 2 JIA subtypes, including 10 novel loci. Functional annotation indicated that candidate genes at these l …
RESULTS: In addition to the major histocompatibility complex locus, we identified 15 genome-wide significant loci shared betwe …
Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.
López-Isac E, Smith SL, Marion MC, Wood A, Sudman M, Yarwood A, Shi C, Gaddi VP, Martin P, Prahalad S, Eyre S, Orozco G, Morris AP, Langefeld CD, Thompson SD, Thomson W, Bowes J. López-Isac E, et al. Ann Rheum Dis. 2021 Mar;80(3):321-328. doi: 10.1136/annrheumdis-2020-218481. Epub 2020 Oct 26. Ann Rheum Dis. 2021. PMID: 33106285 Free PMC article.
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. ...RESULTS: Our analysis provides evidence to support joint analysis of all JIA subtypes with the identification of fi …
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. ...RES …