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Identification of galectins as novel regulators of platelet signaling and function.
Romaniuk MA, Negrotto S, Campetella O, Rabinovich GA, Schattner M. Romaniuk MA, et al. IUBMB Life. 2011 Jul;63(7):521-7. doi: 10.1002/iub.483. IUBMB Life. 2011. PMID: 21698756 Free article. Review.
Activation of platelets is therefore crucial for normal hemostasis. However, uncontrolled platelet activation may also lead to the formation of occlusive thrombi that can cause ischemic events. ...In this article, we review recent advances on the role of galectin
Activation of platelets is therefore crucial for normal hemostasis. However, uncontrolled platelet activation may also lead to …
Binding of galectin-1 to αIIbβ₃ integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis.
Romaniuk MA, Croci DO, Lapponi MJ, Tribulatti MV, Negrotto S, Poirier F, Campetella O, Rabinovich GA, Schattner M. Romaniuk MA, et al. FASEB J. 2012 Jul;26(7):2788-98. doi: 10.1096/fj.11-197541. Epub 2012 Mar 27. FASEB J. 2012. PMID: 22456341
Understanding noncanonical mechanisms of platelet activation represents an important challenge for the identification of novel therapeutic targets in bleeding disorders, thrombosis, and cancer. ...This study identifies a noncanonical mechanism, based on ga
Understanding noncanonical mechanisms of platelet activation represents an important challenge for the identification of no