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Identification of pleiotropic genetic effects on obesity and brain anatomy.
Curran JE, McKay DR, Winkler AM, Olvera RL, Carless MA, Dyer TD, Kent JW Jr, Kochunov P, Sprooten E, Knowles EE, Comuzzie AG, Fox PT, Almasy L, Duggirala R, Blangero J, Glahn DC. Curran JE, et al. Hum Hered. 2013;75(2-4):136-43. doi: 10.1159/000353953. Epub 2013 Sep 27. Hum Hered. 2013. PMID: 24081229 Free PMC article.
In this study, we sought genetic components that influence both brain anatomy and body mass index (BMI) to provide further insight into the role of the brain in energy homeostasis and obesity. ...We identified two genome-wide quantitative trait …
In this study, we sought genetic components that influence both brain anatomy and body mass index (BMI) to provide furt …
Additional common loci associated with stroke and obesity identified using pleiotropic analytical approach.
Wang L, Xu F, Brickell A, Sun N, Mao X, Zhang Q, Wang G, Zhou Q, Yang B, Li F, Yue L, Zhang W, Hao Y, Sun C. Wang L, et al. Mol Genet Genomics. 2020 Mar;295(2):439-451. doi: 10.1007/s00438-019-01630-3. Epub 2019 Dec 7. Mol Genet Genomics. 2020. PMID: 31813042
The corresponding genes were enriched in trait-associated gene ontology (GO) terms "brain development" and "negative regulation of transport". In conclusion, our study demonstrated the feasibility and effectivity of the two pleiotropic methods which successfu …
The corresponding genes were enriched in trait-associated gene ontology (GO) terms "brain development" and "negative regulation of tr …
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