Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 1
1999 2
2001 2
2002 1
2003 1
2004 1
2005 1
2007 2
2008 2
2009 2
2010 6
2011 2
2012 2
2014 2
2015 4
2016 3
2017 3
2018 1
2020 3
2021 1
Text availability
Article attribute
Article type
Publication date

Search Results

36 results
Results by year
Filters applied: . Clear all
Page 1
Your search for Identifying and characterizing che mical skin sensitizers without animal testing retrieved no results
Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program.
Aeby P, Ashikaga T, Bessou-Touya S, Schepky A, Gerberick F, Kern P, Marrec-Fairley M, Maxwell G, Ovigne JM, Sakaguchi H, Reisinger K, Tailhardat M, Martinozzi-Teissier S, Winkler P. Aeby P, et al. Toxicol In Vitro. 2010 Sep;24(6):1465-73. doi: 10.1016/j.tiv.2010.07.005. Epub 2010 Jul 17. Toxicol In Vitro. 2010. PMID: 20624454 Review.
The sensitizing potential of chemicals is usually identified and characterized using one of the available animal test methods, such as the mouse local lymph node assay. ...Data from all three test methods will be used to support th …
The sensitizing potential of chemicals is usually identified and characterized using one of the available ani
The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers-Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility.
Gradin R, Johansson A, Forreryd A, Aaltonen E, Jerre A, Larne O, Mattson U, Johansson H. Gradin R, et al. Toxicol Sci. 2020 Aug 1;176(2):423-432. doi: 10.1093/toxsci/kfaa068. Toxicol Sci. 2020. PMID: 32421796 Free PMC article.
Current legislations and trends in predictive toxicology advocate a transition from in vivo methods to nonanimal alternatives. For skin sensitization assessment, several OECD validated alternatives exist for hazard identification, but nonanimal methods capable of ac …
Current legislations and trends in predictive toxicology advocate a transition from in vivo methods to nonanimal alternatives. For skin
Chemical-induced contact allergy: from mechanistic understanding to risk prevention.
Corsini E, Engin AB, Neagu M, Galbiati V, Nikitovic D, Tzanakakis G, Tsatsakis AM. Corsini E, et al. Arch Toxicol. 2018 Oct;92(10):3031-3050. doi: 10.1007/s00204-018-2283-z. Epub 2018 Aug 10. Arch Toxicol. 2018. PMID: 30097700 Review.
Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. ...Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune disease, resulting in erythema and eczema. Chemical allergy is of considerabl
Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. ...Allergic contact der
Beryllium metal II. a review of the available toxicity data.
Strupp C. Strupp C. Ann Occup Hyg. 2011 Jan;55(1):43-56. doi: 10.1093/annhyg/meq073. Epub 2010 Dec 31. Ann Occup Hyg. 2011. PMID: 21196456 Free PMC article. Review.
Following introduction of the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation, beryllium metal was classified as individual substance and more investigational efforts to appropriately characterize beryllium metal as a specific …
Following introduction of the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation, beryllium meta …
An in vitro human skin test for assessing sensitization potential.
Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, Dickinson AM. Ahmed SS, et al. J Appl Toxicol. 2016 May;36(5):669-84. doi: 10.1002/jat.3197. Epub 2015 Aug 7. J Appl Toxicol. 2016. PMID: 26251951
The current gold-standard method for identification and characterization of skin-sensitizing chemicals was the mouse local lymph node assay (LLNA). ...Using this approach we have measured responses to 44 chemicals including skin sensit
The current gold-standard method for identification and characterization of skin-sensitizing chemicals was the m …
The local lymph node assay and skin sensitization testing.
Kimber I, Dearman RJ. Kimber I, et al. Methods Mol Biol. 2010;598:221-31. doi: 10.1007/978-1-60761-401-2_16. Methods Mol Biol. 2010. PMID: 19967517
The mouse local lymph node assay (LLNA) is a method for the identification and characterization of skin sensitization hazards. In this context the method can be used both to identify contact allergens, and also determine the relative skin sen
The mouse local lymph node assay (LLNA) is a method for the identification and characterization of skin sensitization h …
An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing.
McKim JM Jr, Keller DJ 3rd, Gorski JR. McKim JM Jr, et al. Cutan Ocul Toxicol. 2012 Dec;31(4):292-305. doi: 10.3109/15569527.2012.667031. Epub 2012 Apr 12. Cutan Ocul Toxicol. 2012. PMID: 22494060
This approach combines solubility, chemical reactivity, cytotoxicity, and activation of the Nrf2/ARE expression pathway to identify and categorize chemical sensitizers. Known chemical sensitizers representing extreme/strong-, moderate-, w …
This approach combines solubility, chemical reactivity, cytotoxicity, and activation of the Nrf2/ARE expression pathway to identif
Mapping Chemical Respiratory Sensitization: How Useful Are Our Current Computational Tools?
Golden E, Maertens M, Hartung T, Maertens A. Golden E, et al. Chem Res Toxicol. 2021 Feb 15;34(2):473-482. doi: 10.1021/acs.chemrestox.0c00320. Epub 2020 Dec 15. Chem Res Toxicol. 2021. PMID: 33320000
We identified a data set of known human respiratory sensitizers, which we used to investigate the accuracy of a structural alert model, Toxtree, designed for skin sensitization and the Centre for Occupational and Environmental Health (COEH)'s mo …
We identified a data set of known human respiratory sensitizers, which we used to investigate the accuracy of a structural ale …
Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients.
Gilmour N, Kern PS, Alépée N, Boislève F, Bury D, Clouet E, Hirota M, Hoffmann S, Kühnl J, Lalko JF, Mewes K, Miyazawa M, Nishida H, Osmani A, Petersohn D, Sekine S, van Vliet E, Klaric M. Gilmour N, et al. Regul Toxicol Pharmacol. 2020 Oct;116:104721. doi: 10.1016/j.yrtph.2020.104721. Epub 2020 Jul 6. Regul Toxicol Pharmacol. 2020. PMID: 32645429
All cosmetic products placed onto the market must undergo a risk assessment for human health to ensure they are safe for consumers, including an assessment of skin sensitisation risk. Historically, in vivo animal test methods were used to identify
All cosmetic products placed onto the market must undergo a risk assessment for human health to ensure they are safe for consumers, includin …
Developing a framework for assessing chemical respiratory sensitization: A workshop report.
North CM, Ezendam J, Hotchkiss JA, Maier C, Aoyama K, Enoch S, Goetz A, Graham C, Kimber I, Karjalainen A, Pauluhn J, Roggen EL, Selgrade M, Tarlo SM, Chen CL. North CM, et al. Regul Toxicol Pharmacol. 2016 Oct;80:295-309. doi: 10.1016/j.yrtph.2016.06.006. Epub 2016 Jul 7. Regul Toxicol Pharmacol. 2016. PMID: 27396307
While induction of respiratory sensitization is widely recognized for some chemicals, validated standard methods or frameworks for identifying and characterizing the hazard are not available. ...Progress on non-animal approaches to skin
While induction of respiratory sensitization is widely recognized for some chemicals, validated standard methods or frameworks …
36 results
You have reached the last page of results. A maximum of 10,000 results are available.
Jump to page