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Your search for Identifying and characterizing che mical skin sensitizers without animal testing retrieved no results
Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program.
Aeby P, Ashikaga T, Bessou-Touya S, Schepky A, Gerberick F, Kern P, Marrec-Fairley M, Maxwell G, Ovigne JM, Sakaguchi H, Reisinger K, Tailhardat M, Martinozzi-Teissier S, Winkler P. Aeby P, et al. Toxicol In Vitro. 2010 Sep;24(6):1465-73. doi: 10.1016/j.tiv.2010.07.005. Epub 2010 Jul 17. Toxicol In Vitro. 2010. PMID: 20624454 Review.
The sensitizing potential of chemicals is usually identified and characterized using one of the available animal test methods, such as the mouse local lymph node assay. ...The replacement of the need for animal testing for skin
The sensitizing potential of chemicals is usually identified and characterized using one of the available animal
Chemical-induced contact allergy: from mechanistic understanding to risk prevention.
Corsini E, Engin AB, Neagu M, Galbiati V, Nikitovic D, Tzanakakis G, Tsatsakis AM. Corsini E, et al. Arch Toxicol. 2018 Oct;92(10):3031-3050. doi: 10.1007/s00204-018-2283-z. Epub 2018 Aug 10. Arch Toxicol. 2018. PMID: 30097700 Review.
Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. ...Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune disease, resulting in erythema and eczema. Chemical allergy is of considerable impor
Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. ...Allergic contact dermatitis
The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers-Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility.
Gradin R, Johansson A, Forreryd A, Aaltonen E, Jerre A, Larne O, Mattson U, Johansson H. Gradin R, et al. Toxicol Sci. 2020 Aug 1;176(2):423-432. doi: 10.1093/toxsci/kfaa068. Toxicol Sci. 2020. PMID: 32421796 Free PMC article.
Proactive identification and characterization of hazards attributable to chemicals are central aspects of risk assessments. ...In conclusion, the in vitro GARDpotency assay constitutes a step forward for development of nonanimal alternatives for hazard characteri
Proactive identification and characterization of hazards attributable to chemicals are central aspects of risk assessments. .. …
Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?
Patlewicz G, Casati S, Basketter DA, Asturiol D, Roberts DW, Lepoittevin JP, Worth AP, Aschberger K. Patlewicz G, et al. Regul Toxicol Pharmacol. 2016 Dec;82:147-155. doi: 10.1016/j.yrtph.2016.08.007. Epub 2016 Aug 26. Regul Toxicol Pharmacol. 2016. PMID: 27569201
Predictive testing to characterize substances for their skin sensitization potential has historically been based on animal tests such as the Local Lymph Node Assay (LLNA). ...The analysis here showed that skin metabolism was not li …
Predictive testing to characterize substances for their skin sensitization potential has historically been based …
The local lymph node assay and skin sensitization testing.
Kimber I, Dearman RJ. Kimber I, et al. Methods Mol Biol. 2010;598:221-31. doi: 10.1007/978-1-60761-401-2_16. Methods Mol Biol. 2010. PMID: 19967517
The mouse local lymph node assay (LLNA) is a method for the identification and characterization of skin sensitization hazards. In this context the method can be used both to identify contact allergens, and also determine the relative skin sensit …
The mouse local lymph node assay (LLNA) is a method for the identification and characterization of skin sensitization h …
Quantitative assessment of sensitizing potency using a dose-response adaptation of GARDskin.
Gradin R, Forreryd A, Mattson U, Jerre A, Johansson H. Gradin R, et al. Sci Rep. 2021 Sep 23;11(1):18904. doi: 10.1038/s41598-021-98247-7. Sci Rep. 2021. PMID: 34556744 Free PMC article.
Hundreds of chemicals have been identified as skin sensitizers. These are chemicals that possess the ability to induce hypersensitivity reactions in humans, giving rise to a condition termed allergic contact dermatitis. The capacity to limit haz …
Hundreds of chemicals have been identified as skin sensitizers. These are chemicals that possess the abil …
Mapping Chemical Respiratory Sensitization: How Useful Are Our Current Computational Tools?
Golden E, Maertens M, Hartung T, Maertens A. Golden E, et al. Chem Res Toxicol. 2021 Feb 15;34(2):473-482. doi: 10.1021/acs.chemrestox.0c00320. Epub 2020 Dec 15. Chem Res Toxicol. 2021. PMID: 33320000 Free PMC article.
The Adverse Outcome Pathway (AOP) for respiratory sensitization is currently incomplete. However, some key events have been identified, and there is overlap with the comparatively well-characterized AOP for dermal sensitization. ...There were important …
The Adverse Outcome Pathway (AOP) for respiratory sensitization is currently incomplete. However, some key events have been identi
Beryllium metal II. a review of the available toxicity data.
Strupp C. Strupp C. Ann Occup Hyg. 2011 Jan;55(1):43-56. doi: 10.1093/annhyg/meq073. Epub 2010 Dec 31. Ann Occup Hyg. 2011. PMID: 21196456 Free PMC article. Review.
Following introduction of the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation, beryllium metal was classified as individual substance and more investigational efforts to appropriately characterize beryllium metal as a specific …
Following introduction of the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation, beryllium meta …
An in vitro human skin test for assessing sensitization potential.
Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, Dickinson AM. Ahmed SS, et al. J Appl Toxicol. 2016 May;36(5):669-84. doi: 10.1002/jat.3197. Epub 2015 Aug 7. J Appl Toxicol. 2016. PMID: 26251951
The current gold-standard method for identification and characterization of skin-sensitizing chemicals was the mouse local lymph node assay (LLNA). ...Using this approach we have measured responses to 44 chemicals including skin sensitizers
The current gold-standard method for identification and characterization of skin-sensitizing chemicals was the mouse lo …
Developing a framework for assessing chemical respiratory sensitization: A workshop report.
North CM, Ezendam J, Hotchkiss JA, Maier C, Aoyama K, Enoch S, Goetz A, Graham C, Kimber I, Karjalainen A, Pauluhn J, Roggen EL, Selgrade M, Tarlo SM, Chen CL. North CM, et al. Regul Toxicol Pharmacol. 2016 Oct;80:295-309. doi: 10.1016/j.yrtph.2016.06.006. Epub 2016 Jul 7. Regul Toxicol Pharmacol. 2016. PMID: 27396307
While induction of respiratory sensitization is widely recognized for some chemicals, validated standard methods or frameworks for identifying and characterizing the hazard are not available. ...Progress on non-animal approaches to skin
While induction of respiratory sensitization is widely recognized for some chemicals, validated standard methods or frameworks …
39 results