Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts.
De R, Verma SS, Holzinger E, Hall M, Burt A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Lange LA, Lanktree MB, Larson EB, North KE, Reiner AP, Tragante V, Tromp G, Wilson JG, Asselbergs FW, Drenos F, Moore JH, Ritchie MD, Keating B, Gilbert-Diamond D.
De R, et al.
Hum Genet. 2017 Feb;136(2):165-178. doi: 10.1007/s00439-016-1738-7. Epub 2016 Nov 15.
Hum Genet. 2017.
PMID: 27848076
Genetic loci explain only 25-30 % of the heritability observed in plasma lipid traits. Epistasis, or gene-gene interactions may contribute to a portion of this missing heritability. Using the genetic data from five NHLBI cohorts of 24,837 individuals, we comb …
Genetic loci explain only 25-30 % of the heritability observed in plasma lipid traits. Epistasis, or gene-gene interactions …