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Identifying genetically driven clinical phenotypes using linear mixed models.
Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC. Mosley JD, et al. Nat Commun. 2016 Apr 25;7:11433. doi: 10.1038/ncomms11433. Nat Commun. 2016. PMID: 27109359 Free PMC article.
We hypothesized that generalized linear mixed models (GLMMs), which estimate the additive genetic variance underlying phenotype variability, would facilitate rapid characterization of clinical phenotypes from an electronic health r …
We hypothesized that generalized linear mixed models (GLMMs), which estimate the additive genetic variance under …
Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016.
Srivastava AK, Wang Y, Huang R, Skinner C, Thompson T, Pollard L, Wood T, Luo F, Stevenson R, Polimanti R, Gelernter J, Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Yap F, Kwek K, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group; Kapoor A, Lee D, Chakravarti A, Maercker C, Graf F, Boutros M, Stamoulis G, Santoni F, Makrythanasis P, Letourneau A, Guipponi M, Panousis N, Garieri M, Ribaux P, Falconnet E, Borel C, Antonarakis SE, Kumar S, Curran J, Blangero J, Chatterjee S, Kapoor A, Akiyama J, Auer D, Berrios C, Pennacchio L, Chakravarti A, Donti TR, Cappuccio G, Miller M, Atwal P, Kennedy A, Cardon A, Bacino C, Emrick L, Hertecant J, Baumer F, Porter B, Bainbridge M, Bonnen P, Graham B, Sutton R, Sun Q, Elsea S, Hu Z, Wang P, Zhu Y, Zhao J, Xiong M, Bennett DA, Hidalgo-Miranda A, Romero-Cordoba S, Rodriguez-Cuevas S, Rebollar-Vega R, Tagliabue E, Iorio M, D’Ippolito E, Baroni S, Kaczkowski B, Tanaka Y, Kawaji H, Sandelin A, Andersson R, Itoh M, Lassmann T; The FANTOM5 Consortium; Hayashizaki Y, Carninci P, Forrest ARR, Semple CA, Rosenthal EA, Shirts B, Amendola L, Gallego C, Horike-Pyne… See abstract for full author list ➔ Srivastava AK, et al. Hum Genomics. 2016 May 26;10 Suppl 1(Suppl 1):12. doi: 10.1186/s40246-016-0063-5. Hum Genomics. 2016. PMID: 27294413 Free PMC article.
Karuturi, J. Keck, J. Chuang, E. T. Liu O16 Modeling genetic interactions associated with molecular subtypes of breast cancer B. Ji, A. ...Xu P51 A Bayesian framework for generalized linear mixed models in genome-wide association studies X. Wang …
Karuturi, J. Keck, J. Chuang, E. T. Liu O16 Modeling genetic interactions associated with molecular subtypes of breast cancer …
Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach.
Putcha D, Katsumi Y, Touroutoglou A, Eloyan A, Taurone A, Thangarajah M, Aisen P, Dage JL, Foroud T, Jack CR Jr, Kramer JH, Nudelman KNH, Raman R, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Grant IM, Honig LS, Johnson ECB, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha S, Turner RS, Wingo TS, Wolk DA, Womack K, Carrillo MC, Rabinovici GD, Dickerson BC, Apostolova LG, Hammers DB; LEADS Consortium. Putcha D, et al. Alzheimers Res Ther. 2025 Feb 6;17(1):38. doi: 10.1186/s13195-025-01689-8. Alzheimers Res Ther. 2025. PMID: 39915859 Free PMC article.
Whole-cortex general linear modeling of cortical atrophy was applied as an MRI-based validation of these distinct clinical phenotypes. ...CONCLUSION: A neuropsychological data-driven method to phenotype EOAD individuals uncovered a more d …
Whole-cortex general linear modeling of cortical atrophy was applied as an MRI-based validation of these distinct clinical …
Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum.
Illán-Gala I, Lorca-Puls DL, Tee BL, Ezzes Z, de Leon J, Miller ZA, Rubio-Guerra S, Santos-Santos M, Gómez-Andrés D, Grinberg LT, Spina S, Kramer JH, Wauters LD, Henry ML, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Mandelli ML, Gorno-Tempini ML. Illán-Gala I, et al. Brain. 2024 Apr 4;147(4):1511-1525. doi: 10.1093/brain/awad396. Brain. 2024. PMID: 37988272 Free PMC article.
We also assessed if data-driven latent clinical dimensions with aetiologic/prognostic value could be identified. ...The longitudinal CDR-SB change was estimated using linear mixed-effects models. Of the participants included in this study …
We also assessed if data-driven latent clinical dimensions with aetiologic/prognostic value could be identified. ...The …
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits.
Poveda A, Pomares-Millan H, Chen Y, Kurbasic A, Patel CJ, Renström F, Hallmans G, Johansson I, Franks PW. Poveda A, et al. Sci Rep. 2022 Mar 8;12(1):4088. doi: 10.1038/s41598-022-08050-1. Sci Rep. 2022. PMID: 35260745 Free PMC article.
The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test …
The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed …
Integrative model of leukocyte genomics and organ dysfunction in heart failure patients requiring mechanical circulatory support: a prospective observational study.
Wisniewski N, Bondar G, Rau C, Chittoor J, Chang E, Esmaeili A, Cadeiras M, Deng M. Wisniewski N, et al. BMC Med Genomics. 2017 Aug 29;10(1):52. doi: 10.1186/s12920-017-0288-8. BMC Med Genomics. 2017. PMID: 28851355 Free PMC article.
Clinical phenotyping was performed using 12 clinical parameters, 2 organ dysfunction scoring systems, and survival outcomes. ...Genes and eigengenes were mapped to the clinical phenotype using a linear mixed-effect model, wi …
Clinical phenotyping was performed using 12 clinical parameters, 2 organ dysfunction scoring systems, and survival outc …
Association between cognitive phenotype in unaffected siblings and prospective 3- and 6-year clinical outcome in their proband affected by psychosis.
Burger TJ, Schirmbeck F, Vermeulen JM, Quee PJ, de Koning MB, Bruggeman R, de Haan L; GROUP investigator. Burger TJ, et al. Psychol Med. 2021 Aug;51(11):1916-1926. doi: 10.1017/S0033291720000719. Epub 2020 Apr 15. Psychol Med. 2021. PMID: 32290874
Generalized linear mixed models assessed multi-cross-sectional associations between the sibling cognitive subtype and repeated measures of proband symptoms across all assessments. ...CONCLUSIONS: Cross-sibling pathways from higher levels of familial cognitive …
Generalized linear mixed models assessed multi-cross-sectional associations between the sibling cognitive subtype and r …