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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1961 2
1964 1
1965 2
1966 3
1967 2
1968 9
1969 4
1970 5
1971 8
1972 15
1973 8
1974 17
1975 44
1976 51
1977 51
1978 57
1979 98
1980 109
1981 120
1982 171
1983 241
1984 304
1985 361
1986 456
1987 499
1988 597
1989 733
1990 891
1991 1151
1992 1335
1993 1684
1994 2045
1995 2380
1996 2826
1997 3068
1998 3546
1999 4010
2000 4545
2001 5026
2002 5738
2003 6385
2004 7544
2005 8076
2006 9382
2007 9942
2008 10704
2009 11410
2010 12848
2011 14230
2012 15601
2013 17074
2014 18097
2015 18987
2016 19313
2017 20234
2018 21192
2019 22048
2020 13915
2021 1
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269,548 results
Results by year

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ROS signalling in the biology of cancer.
Moloney JN, Cotter TG. Moloney JN, et al. Semin Cell Dev Biol. 2018 Aug;80:50-64. doi: 10.1016/j.semcdb.2017.05.023. Epub 2017 Jun 3. Semin Cell Dev Biol. 2018. PMID: 28587975 Review.
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. ...Tumour cells have an altered redox balance to that of their normal counterparts and this identifies ROS manipulation as a potential
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. ...Tumou …
Identifying signals of potentially harmful medications in pregnancy: use of the double false discovery rate method to adjust for multiple testing.
Cavadino A, Prieto-Merino D, Morris JK. Cavadino A, et al. Br J Clin Pharmacol. 2019 Feb;85(2):356-365. doi: 10.1111/bcp.13799. Epub 2018 Nov 26. Br J Clin Pharmacol. 2019. PMID: 30350871 Free PMC article.
AIMS: Surveillance of medication use in pregnancy is essential to identify associations between first trimester medications and congenital anomalies (CAs). ...The Australian classification system was used to identify high-risk medications
AIMS: Surveillance of medication use in pregnancy is essential to identify associations between first trimester medi
Regulation and plasticity of intestinal stem cells during homeostasis and regeneration.
Beumer J, Clevers H. Beumer J, et al. Development. 2016 Oct 15;143(20):3639-3649. doi: 10.1242/dev.133132. Development. 2016. PMID: 27802133 Free article. Review.
Here, we review our current understanding of how intestinal stem and progenitor cells contribute to homeostasis and regeneration, and the different signaling pathways that regulate their behavior. Nutritional state and inflammation have been recently identified as u …
Here, we review our current understanding of how intestinal stem and progenitor cells contribute to homeostasis and regeneration, and the di …
STING Signaling Promotes Apoptosis, Necrosis, and Cell Death: An Overview and Update.
Liu S, Guan W. Liu S, et al. Mediators Inflamm. 2018 Nov 25;2018:1202797. doi: 10.1155/2018/1202797. eCollection 2018. Mediators Inflamm. 2018. PMID: 30595664 Free PMC article. Review.
STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has been recognized as an activator of immune responses by TBK1/IRF3 and NF-κB pathways, and it is suggested to play critical roles in host defense, autoimmune diseases, and tumor immunit …
STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has been recognized as an activator of immune r …
Auxin signal transduction.
Hagen G. Hagen G. Essays Biochem. 2015;58:1-12. doi: 10.1042/bse0580001. Essays Biochem. 2015. PMID: 26374883 Review.
A combination of molecular, genetic and biochemical approaches has identified several key components involved in auxin signal transduction. ...Future goals are to determine the levels of regulation of the key components of the transcriptional complex, to i
A combination of molecular, genetic and biochemical approaches has identified several key components involved in auxin signal
Advances and challenges in uncovering cold tolerance regulatory mechanisms in plants.
Ding Y, Shi Y, Yang S. Ding Y, et al. New Phytol. 2019 Jun;222(4):1690-1704. doi: 10.1111/nph.15696. Epub 2019 Feb 25. New Phytol. 2019. PMID: 30664232 Free article. Review.
Sensing of cold signals in plants IV. Messenger molecules involved in cold signal transduction V. Cold signal transduction in plants VI. ...Over the past two decades, much progress has been made in identifying crucial components involved …
Sensing of cold signals in plants IV. Messenger molecules involved in cold signal transduction V. Cold signal
The corticosteroid receptor hypothesis of depression.
Holsboer F. Holsboer F. Neuropsychopharmacology. 2000 Nov;23(5):477-501. doi: 10.1016/S0893-133X(00)00159-7. Neuropsychopharmacology. 2000. PMID: 11027914 Free article. Review.
Mouse genetics, allowing for selective inactivation of genes relevant for HPA regulation and molecular pharmacology, dissecting the intracellular cascade of CR signaling, are the most promising future research fields, suited for identifying genes predisposing to dep …
Mouse genetics, allowing for selective inactivation of genes relevant for HPA regulation and molecular pharmacology, dissecting the intracel …
An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis.
Bhandari DD, Lapin D, Kracher B, von Born P, Bautor J, Niefind K, Parker JE. Bhandari DD, et al. Nat Commun. 2019 Feb 15;10(1):772. doi: 10.1038/s41467-019-08783-0. Nat Commun. 2019. PMID: 30770836 Free PMC article.
By interrogating the Arabidopsis EDS1 ɑ-helical EP-domain we identify positively charged residues lining a cavity that are essential for TNL immunity signalling, beyond heterodimer formation. ...These data provide a unique structural insight to early downstream s
By interrogating the Arabidopsis EDS1 ɑ-helical EP-domain we identify positively charged residues lining a cavity that are essential …
The Role of Redox in Signal Transduction.
Hancock JT. Hancock JT. Methods Mol Biol. 2019;1990:1-11. doi: 10.1007/978-1-4939-9463-2_1. Methods Mol Biol. 2019. PMID: 31148058
Over many years various components have been identified and recognized as crucial for the transduction of signals in cells, including small organic molecules and ions. ...Here, the chemistry of redox modification of amino acids is introduced, and a general ov …
Over many years various components have been identified and recognized as crucial for the transduction of signals in ce …
Emerging roles of lncRNAs in senescence.
Montes M, Lund AH. Montes M, et al. FEBS J. 2016 Jul;283(13):2414-26. doi: 10.1111/febs.13679. Epub 2016 Mar 2. FEBS J. 2016. PMID: 26866709 Free article. Review.
Many molecules have been identified as regulators of these two networks, such as transcription factors, chromatin modifiers and non-coding RNAs. ...Here we review our current knowledge of the mechanistic roles of lncRNAs affecting the main senescence pathways, and discuss …
Many molecules have been identified as regulators of these two networks, such as transcription factors, chromatin modifiers and non-c …
269,548 results
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