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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1961 2
1964 1
1965 2
1966 3
1967 2
1968 9
1969 5
1970 5
1971 8
1972 15
1973 8
1974 17
1975 44
1976 52
1977 51
1978 57
1979 100
1980 109
1981 120
1982 171
1983 241
1984 304
1985 361
1986 457
1987 499
1988 597
1989 733
1990 891
1991 1151
1992 1340
1993 1690
1994 2050
1995 2383
1996 2831
1997 3071
1998 3550
1999 4026
2000 4568
2001 5051
2002 5764
2003 6417
2004 7577
2005 8105
2006 9416
2007 9979
2008 10756
2009 11460
2010 12907
2011 14314
2012 15717
2013 17204
2014 18246
2015 19158
2016 19519
2017 20479
2018 21556
2019 23010
2020 25425
2021 27834
2022 27431
2023 27042
2024 12308

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366,770 results

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Page 1
ROS signalling in the biology of cancer.
Moloney JN, Cotter TG. Moloney JN, et al. Semin Cell Dev Biol. 2018 Aug;80:50-64. doi: 10.1016/j.semcdb.2017.05.023. Epub 2017 Jun 3. Semin Cell Dev Biol. 2018. PMID: 28587975 Review.
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour cells express elevated levels of antioxidant proteins to detoxify elevated ROS levels, establish a redox balance, while maintaining pro-tumou …
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour c …
Central 5-HT receptors and their function; present and future.
Sharp T, Barnes NM. Sharp T, et al. Neuropharmacology. 2020 Oct 15;177:108155. doi: 10.1016/j.neuropharm.2020.108155. Epub 2020 Jun 6. Neuropharmacology. 2020. PMID: 32522572 Review.
Moreover, unexpected complexity in 5-HT receptor function has been identified including agonist-dependent signalling that goes beyond the pharmacology of canonical 5-HT receptor signalling pathways set down in the 1980s and 1990s. This new knowledge of 5-HT …
Moreover, unexpected complexity in 5-HT receptor function has been identified including agonist-dependent signalling that goes …
Protein multi-functionality: introduction.
Gurevich VV. Gurevich VV. Cell Mol Life Sci. 2019 Nov;76(22):4405-4406. doi: 10.1007/s00018-019-03271-6. Epub 2019 Aug 17. Cell Mol Life Sci. 2019. PMID: 31422443 Free PMC article. Review.
Particular functions in a multi-functional protein are often fulfilled by identifiable smaller elements that can be expressed separately. Identification of mono-functional elements of a multi-functional protein paves the way to the construction of novel precisely targeted …
Particular functions in a multi-functional protein are often fulfilled by identifiable smaller elements that can be expressed separat …
Personalized phosphoproteomics identifies functional signaling.
Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Højlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmøller C, James DE, Wojtaszewski JFP, Humphrey SJ. Needham EJ, et al. Nat Biotechnol. 2022 Apr;40(4):576-584. doi: 10.1038/s41587-021-01099-9. Epub 2021 Dec 2. Nat Biotechnol. 2022. PMID: 34857927
We measure individual subject phosphoproteome responses to interventions with corresponding phenotypes measured in parallel. Applying this approach to investigate how exercise potentiates insulin signaling in human skeletal muscle, we identify both known and …
We measure individual subject phosphoproteome responses to interventions with corresponding phenotypes measured in parallel. Applying this a …
Identifying signals of potentially harmful medications in pregnancy: use of the double false discovery rate method to adjust for multiple testing.
Cavadino A, Prieto-Merino D, Morris JK. Cavadino A, et al. Br J Clin Pharmacol. 2019 Feb;85(2):356-365. doi: 10.1111/bcp.13799. Epub 2018 Nov 26. Br J Clin Pharmacol. 2019. PMID: 30350871 Free PMC article.
The Australian classification system was used to identify high-risk medications in order to compare two methods of controlling the false discovery rate (FDR): a single FDR applied across all combinations, and a double FDR incorpora …
The Australian classification system was used to identify high-risk medications in order to compare two methods of cont …
Interorganellar communication.
Pesaresi P, Schneider A, Kleine T, Leister D. Pesaresi P, et al. Curr Opin Plant Biol. 2007 Dec;10(6):600-6. doi: 10.1016/j.pbi.2007.07.007. Epub 2007 Aug 23. Curr Opin Plant Biol. 2007. PMID: 17719262 Review.
Signals originating from chloroplasts and mitochondria modulate nuclear gene expression (retrograde signalling). ...In addition, multiple interactions of these four pathways with sugar and hormone signalling occur. ...
Signals originating from chloroplasts and mitochondria modulate nuclear gene expression (retrograde signalling). ...In additio
Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract.
Kola JB, Docsa T, Uray K. Kola JB, et al. Int J Mol Sci. 2022 Dec 22;24(1):177. doi: 10.3390/ijms24010177. Int J Mol Sci. 2022. PMID: 36613619 Free PMC article. Review.
Normal gastrointestinal function relies on sensing and transducing mechanical signals into changes in intracellular signaling pathways. Both specialized mechanosensing cells, such as certain enterochromaffin cells and enteric neurons, and non-specialized cells, such …
Normal gastrointestinal function relies on sensing and transducing mechanical signals into changes in intracellular signaling
[Malignant lymphoma].
Kato H, Kinoshita T. Kato H, et al. Rinsho Ketsueki. 2016 Mar;57(3):249-59. doi: 10.11406/rinketsu.57.249. Rinsho Ketsueki. 2016. PMID: 27076235 Japanese.
The development of high throughput technologies based on knowledge of the human genome identifies novel mutations, epigenetic alterations, and signaling pathways characteristics of each of the lymphoma subtypes. The mutational landscape of tumors may have a clinical …
The development of high throughput technologies based on knowledge of the human genome identifies novel mutations, epigenetic alterat …
Decoding Galphaq signaling.
Litosch I. Litosch I. Life Sci. 2016 May 1;152:99-106. doi: 10.1016/j.lfs.2016.03.037. Epub 2016 Mar 22. Life Sci. 2016. PMID: 27012764 Review.
While the fundamental steps which prime Galphaq to interact with PLC-beta have been identified, questions remain concerning signal strength with PLC-beta and other effectors. ...A better understanding of allosteric modulation may therefore identify a wealth o …
While the fundamental steps which prime Galphaq to interact with PLC-beta have been identified, questions remain concerning signal
Mobile signals in systemic acquired resistance.
Kachroo A, Kachroo P. Kachroo A, et al. Curr Opin Plant Biol. 2020 Dec;58:41-47. doi: 10.1016/j.pbi.2020.10.004. Epub 2020 Nov 14. Curr Opin Plant Biol. 2020. PMID: 33202317 Review.
Several SAR-inducing chemicals that could be classified as the potential mobile signal have been identified. Many of these function in a bifurcate pathway with both branches being equally essential for SAR induction. This review reflects on the potential
Several SAR-inducing chemicals that could be classified as the potential mobile signal have been identified. Many of th …
366,770 results
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