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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1961 2
1964 1
1965 2
1966 3
1967 2
1968 9
1969 5
1970 5
1971 8
1972 15
1973 8
1974 17
1975 44
1976 52
1977 51
1978 57
1979 100
1980 109
1981 120
1982 171
1983 241
1984 304
1985 361
1986 457
1987 499
1988 597
1989 733
1990 891
1991 1151
1992 1340
1993 1690
1994 2050
1995 2383
1996 2831
1997 3071
1998 3550
1999 4026
2000 4568
2001 5051
2002 5764
2003 6417
2004 7577
2005 8105
2006 9416
2007 9979
2008 10756
2009 11460
2010 12907
2011 14314
2012 15717
2013 17204
2014 18246
2015 19157
2016 19518
2017 20478
2018 21557
2019 23013
2020 25426
2021 27835
2022 27432
2023 27045
2024 14837
2025 1

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369,222 results

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Page 1
ROS signalling in the biology of cancer.
Moloney JN, Cotter TG. Moloney JN, et al. Semin Cell Dev Biol. 2018 Aug;80:50-64. doi: 10.1016/j.semcdb.2017.05.023. Epub 2017 Jun 3. Semin Cell Dev Biol. 2018. PMID: 28587975 Review.
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour cells express elevated levels of antioxidant proteins to detoxify elevated ROS levels, establish a redox balance, while maintaining pro-tumou …
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour c …
Central 5-HT receptors and their function; present and future.
Sharp T, Barnes NM. Sharp T, et al. Neuropharmacology. 2020 Oct 15;177:108155. doi: 10.1016/j.neuropharm.2020.108155. Epub 2020 Jun 6. Neuropharmacology. 2020. PMID: 32522572 Review.
Moreover, unexpected complexity in 5-HT receptor function has been identified including agonist-dependent signalling that goes beyond the pharmacology of canonical 5-HT receptor signalling pathways set down in the 1980s and 1990s. This new knowledge of 5-HT …
Moreover, unexpected complexity in 5-HT receptor function has been identified including agonist-dependent signalling that goes …
Protein multi-functionality: introduction.
Gurevich VV. Gurevich VV. Cell Mol Life Sci. 2019 Nov;76(22):4405-4406. doi: 10.1007/s00018-019-03271-6. Epub 2019 Aug 17. Cell Mol Life Sci. 2019. PMID: 31422443 Free PMC article. Review.
Particular functions in a multi-functional protein are often fulfilled by identifiable smaller elements that can be expressed separately. Identification of mono-functional elements of a multi-functional protein paves the way to the construction of novel precisely targeted …
Particular functions in a multi-functional protein are often fulfilled by identifiable smaller elements that can be expressed separat …
Personalized phosphoproteomics identifies functional signaling.
Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Højlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmøller C, James DE, Wojtaszewski JFP, Humphrey SJ. Needham EJ, et al. Nat Biotechnol. 2022 Apr;40(4):576-584. doi: 10.1038/s41587-021-01099-9. Epub 2021 Dec 2. Nat Biotechnol. 2022. PMID: 34857927
We measure individual subject phosphoproteome responses to interventions with corresponding phenotypes measured in parallel. Applying this approach to investigate how exercise potentiates insulin signaling in human skeletal muscle, we identify both known and …
We measure individual subject phosphoproteome responses to interventions with corresponding phenotypes measured in parallel. Applying this a …
Identifying signals of potentially harmful medications in pregnancy: use of the double false discovery rate method to adjust for multiple testing.
Cavadino A, Prieto-Merino D, Morris JK. Cavadino A, et al. Br J Clin Pharmacol. 2019 Feb;85(2):356-365. doi: 10.1111/bcp.13799. Epub 2018 Nov 26. Br J Clin Pharmacol. 2019. PMID: 30350871 Free PMC article.
The Australian classification system was used to identify high-risk medications in order to compare two methods of controlling the false discovery rate (FDR): a single FDR applied across all combinations, and a double FDR incorpora …
The Australian classification system was used to identify high-risk medications in order to compare two methods of cont …
Notch-mediated cellular interactions between vascular cells.
Cuervo H, Mühleder S, García-Gónzalez I, Benedito R. Cuervo H, et al. Curr Opin Cell Biol. 2023 Dec;85:102254. doi: 10.1016/j.ceb.2023.102254. Epub 2023 Oct 11. Curr Opin Cell Biol. 2023. PMID: 37832167 Review.
Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits the cell-cycle and metabolism of endotheli …
Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and me …
Decoding Galphaq signaling.
Litosch I. Litosch I. Life Sci. 2016 May 1;152:99-106. doi: 10.1016/j.lfs.2016.03.037. Epub 2016 Mar 22. Life Sci. 2016. PMID: 27012764 Review.
While the fundamental steps which prime Galphaq to interact with PLC-beta have been identified, questions remain concerning signal strength with PLC-beta and other effectors. ...A better understanding of allosteric modulation may therefore identify a wealth o …
While the fundamental steps which prime Galphaq to interact with PLC-beta have been identified, questions remain concerning signal
Interorganellar communication.
Pesaresi P, Schneider A, Kleine T, Leister D. Pesaresi P, et al. Curr Opin Plant Biol. 2007 Dec;10(6):600-6. doi: 10.1016/j.pbi.2007.07.007. Epub 2007 Aug 23. Curr Opin Plant Biol. 2007. PMID: 17719262 Review.
Signals originating from chloroplasts and mitochondria modulate nuclear gene expression (retrograde signalling). ...In addition, multiple interactions of these four pathways with sugar and hormone signalling occur. ...
Signals originating from chloroplasts and mitochondria modulate nuclear gene expression (retrograde signalling). ...In additio
[Malignant lymphoma].
Kato H, Kinoshita T. Kato H, et al. Rinsho Ketsueki. 2016 Mar;57(3):249-59. doi: 10.11406/rinketsu.57.249. Rinsho Ketsueki. 2016. PMID: 27076235 Japanese.
The development of high throughput technologies based on knowledge of the human genome identifies novel mutations, epigenetic alterations, and signaling pathways characteristics of each of the lymphoma subtypes. The mutational landscape of tumors may have a clinical …
The development of high throughput technologies based on knowledge of the human genome identifies novel mutations, epigenetic alterat …
Ca(2+)-calmodulin signalling at the host-pathogen interface.
Wanford JJ, Odendall C. Wanford JJ, et al. Curr Opin Microbiol. 2023 Apr;72:102267. doi: 10.1016/j.mib.2023.102267. Epub 2023 Jan 28. Curr Opin Microbiol. 2023. PMID: 36716574 Free article. Review.
Multiple eukaryotic cell processes are modulated by calcium ions (Ca(2+)). As such, Ca(2+) is emerging as a crucial regulator of innate immunity in multicellular organisms. In particular, recent studies have identified roles of Ca(2+) signalling at the host-b
Multiple eukaryotic cell processes are modulated by calcium ions (Ca(2+)). As such, Ca(2+) is emerging as a crucial regulator of inna
369,222 results
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