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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1961 2
1964 1
1965 2
1966 3
1967 2
1968 9
1969 5
1970 5
1971 8
1972 15
1973 8
1974 17
1975 44
1976 52
1977 51
1978 57
1979 100
1980 109
1981 120
1982 171
1983 241
1984 304
1985 361
1986 457
1987 499
1988 597
1989 733
1990 891
1991 1151
1992 1340
1993 1686
1994 2045
1995 2382
1996 2829
1997 3071
1998 3549
1999 4026
2000 4567
2001 5050
2002 5764
2003 6416
2004 7577
2005 8105
2006 9416
2007 9980
2008 10756
2009 11459
2010 12906
2011 14300
2012 15697
2013 17180
2014 18225
2015 19127
2016 19490
2017 20450
2018 21526
2019 22940
2020 25357
2021 27752
2022 11173
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316,048 results
Results by year

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ROS signalling in the biology of cancer.
Moloney JN, Cotter TG. Moloney JN, et al. Semin Cell Dev Biol. 2018 Aug;80:50-64. doi: 10.1016/j.semcdb.2017.05.023. Epub 2017 Jun 3. Semin Cell Dev Biol. 2018. PMID: 28587975 Review.
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour cells express elevated levels of antioxidant proteins to detoxify elevated ROS levels, establish a redox balance, while maintaining pro-tumou …
Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour c …
Ethylene signaling in rice and Arabidopsis: New regulators and mechanisms.
Zhao H, Yin CC, Ma B, Chen SY, Zhang JS. Zhao H, et al. J Integr Plant Biol. 2021 Jan;63(1):102-125. doi: 10.1111/jipb.13028. J Integr Plant Biol. 2021. PMID: 33095478 Review.
In addition to this canonical signaling pathway, an alternative ethylene receptor-mediated phosphor-relay pathway has also been proposed to participate in ethylene signaling. ...Several novel regulators and/or mechanisms of the rice ethylene signaling pathway …
In addition to this canonical signaling pathway, an alternative ethylene receptor-mediated phosphor-relay pathway has also been propo …
Identifying signals of potentially harmful medications in pregnancy: use of the double false discovery rate method to adjust for multiple testing.
Cavadino A, Prieto-Merino D, Morris JK. Cavadino A, et al. Br J Clin Pharmacol. 2019 Feb;85(2):356-365. doi: 10.1111/bcp.13799. Epub 2018 Nov 26. Br J Clin Pharmacol. 2019. PMID: 30350871 Free PMC article.
The Australian classification system was used to identify high-risk medications in order to compare two methods of controlling the false discovery rate (FDR): a single FDR applied across all combinations, and a double FDR incorpora …
The Australian classification system was used to identify high-risk medications in order to compare two methods of cont …
Brassinosteroid signalling.
Zhu JY, Sae-Seaw J, Wang ZY. Zhu JY, et al. Development. 2013 Apr;140(8):1615-20. doi: 10.1242/dev.060590. Development. 2013. PMID: 23533170 Free PMC article. Review.
The brassinosteroid (BR) class of steroid hormones regulates plant development and physiology. The BR signal is transduced by a receptor kinase-mediated signal transduction pathway, which is distinct from animal steroid signalling systems. Recent studi …
The brassinosteroid (BR) class of steroid hormones regulates plant development and physiology. The BR signal is transduced by a recep …
Interorganellar communication.
Pesaresi P, Schneider A, Kleine T, Leister D. Pesaresi P, et al. Curr Opin Plant Biol. 2007 Dec;10(6):600-6. doi: 10.1016/j.pbi.2007.07.007. Epub 2007 Aug 23. Curr Opin Plant Biol. 2007. PMID: 17719262 Review.
Signals originating from chloroplasts and mitochondria modulate nuclear gene expression (retrograde signalling). ...In addition, multiple interactions of these four pathways with sugar and hormone signalling occur. ...
Signals originating from chloroplasts and mitochondria modulate nuclear gene expression (retrograde signalling). ...In additio
Decoding Gαq signaling.
Litosch I. Litosch I. Life Sci. 2016 May 1;152:99-106. doi: 10.1016/j.lfs.2016.03.037. Epub 2016 Mar 22. Life Sci. 2016. PMID: 27012764 Review.
While the fundamental steps which prime Galphaq to interact with PLC-beta have been identified, questions remain concerning signal strength with PLC-beta and other effectors. ...A better understanding of allosteric modulation may therefore identify a wealth o …
While the fundamental steps which prime Galphaq to interact with PLC-beta have been identified, questions remain concerning signal
Auxin signal transduction.
Hagen G. Hagen G. Essays Biochem. 2015;58:1-12. doi: 10.1042/bse0580001. Essays Biochem. 2015. PMID: 26374883 Review.
A combination of molecular, genetic and biochemical approaches has identified several key components involved in auxin signal transduction. ...Future goals are to determine the levels of regulation of the key components of the transcriptional complex, to i
A combination of molecular, genetic and biochemical approaches has identified several key components involved in auxin signal
The role of the 12(S)-HETE/GPR31/12-HETER axis in cancer and ischemia-reperfusion injury.
Napolitano M. Napolitano M. Biochem Soc Trans. 2019 Apr 30;47(2):743-754. doi: 10.1042/BST20180635. Epub 2019 Mar 22. Biochem Soc Trans. 2019. PMID: 30902921 Review.
Recent studies shed light and interest on the 12(S)-HETE/GPR31/12-HETER-activated signaling pathways and functions. The full spectrum of GPR31/12-HETER-mediated biological functions has yet to be characterized. Further studies are needed to identify other …
Recent studies shed light and interest on the 12(S)-HETE/GPR31/12-HETER-activated signaling pathways and functions. The full s …
[Malignant lymphoma].
Kato H, Kinoshita T. Kato H, et al. Rinsho Ketsueki. 2016 Mar;57(3):249-59. doi: 10.11406/rinketsu.57.249. Rinsho Ketsueki. 2016. PMID: 27076235 Japanese.
The development of high throughput technologies based on knowledge of the human genome identifies novel mutations, epigenetic alterations, and signaling pathways characteristics of each of the lymphoma subtypes. The mutational landscape of tumors may have a clinical …
The development of high throughput technologies based on knowledge of the human genome identifies novel mutations, epigenetic alterat …
Is the Quest for Signaling Bias Worth the Effort?
Kenakin T. Kenakin T. Mol Pharmacol. 2018 Apr;93(4):266-269. doi: 10.1124/mol.117.111187. Epub 2018 Jan 18. Mol Pharmacol. 2018. PMID: 29348268 Review.
The question of whether signaling bias is a viable discovery strategy for drug therapy is discussed as a value proposition. On the positive side, bias is easily identified and quantified in simple in vitro functional assays with little resource expenditure. . …
The question of whether signaling bias is a viable discovery strategy for drug therapy is discussed as a value proposition. On …
316,048 results
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