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98 results
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Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway.
Fuerer C, Iggo R. Fuerer C, et al. Among authors: iggo r. Gene Ther. 2002 Feb;9(4):270-81. doi: 10.1038/sj.gt.3301651. Gene Ther. 2002. PMID: 11896466
Monitoring adenoviral p53 transduction efficiency by yeast functional assay.
Tada M, Sakuma S, Iggo RD, Saya H, Sawamura Y, Fujiwara T, Roth JA. Tada M, et al. Among authors: iggo rd. Gene Ther. 1998 Mar;5(3):339-44. doi: 10.1038/sj.gt.3300605. Gene Ther. 1998. PMID: 9614553
Mammalian p53 can function as a transcription factor in yeast.
Schärer E, Iggo R. Schärer E, et al. Among authors: iggo r. Nucleic Acids Res. 1992 Apr 11;20(7):1539-45. doi: 10.1093/nar/20.7.1539. Nucleic Acids Res. 1992. PMID: 1579447 Free PMC article.
Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells.
Fuerer C, Homicsko K, Lukashev AN, Pittet AL, Iggo RD. Fuerer C, et al. BMC Cancer. 2006 Oct 4;6:236. doi: 10.1186/1471-2407-6-236. BMC Cancer. 2006. PMID: 17020613 Free PMC article.
RAD001 (everolimus) improves the efficacy of replicating adenoviruses that target colon cancer.
Homicsko K, Lukashev A, Iggo RD. Homicsko K, et al. Cancer Res. 2005 Aug 1;65(15):6882-90. doi: 10.1158/0008-5472.CAN-05-0309. Cancer Res. 2005. PMID: 16061672
Determinants of interferon-stimulated gene induction by RNAi vectors.
Pebernard S, Iggo RD. Pebernard S, et al. Differentiation. 2004 Mar;72(2-3):103-11. doi: 10.1111/j.1432-0436.2004.07202001.x. Differentiation. 2004. PMID: 15066190
Regulation of p53 stability and function in HCT116 colon cancer cells.
Kaeser MD, Pebernard S, Iggo RD. Kaeser MD, et al. J Biol Chem. 2004 Feb 27;279(9):7598-605. doi: 10.1074/jbc.M311732200. Epub 2003 Dec 9. J Biol Chem. 2004. PMID: 14665630
Promoter-specific p53-dependent histone acetylation following DNA damage.
Kaeser MD, Iggo RD. Kaeser MD, et al. Oncogene. 2004 May 13;23(22):4007-13. doi: 10.1038/sj.onc.1207536. Oncogene. 2004. PMID: 15007388
Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954.
Lukashev AN, Fuerer C, Chen MJ, Searle P, Iggo R. Lukashev AN, et al. Among authors: iggo r. Hum Gene Ther. 2005 Dec;16(12):1473-83. doi: 10.1089/hum.2005.16.1473. Hum Gene Ther. 2005. PMID: 16390278
Induction of an interferon response by RNAi vectors in mammalian cells.
Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL, Iggo R. Bridge AJ, et al. Among authors: iggo r. Nat Genet. 2003 Jul;34(3):263-4. doi: 10.1038/ng1173. Nat Genet. 2003. PMID: 12796781
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