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von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.
Kuznetsova AV, Meller J, Schnell PO, Nash JA, Ignacak ML, Sanchez Y, Conaway JW, Conaway RC, Czyzyk-Krzeska MF. Kuznetsova AV, et al. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2706-11. doi: 10.1073/pnas.0436037100. Epub 2003 Feb 25. Proc Natl Acad Sci U S A. 2003. PMID: 12604794 Free PMC article.
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
Mikhaylova O, Ignacak ML, Barankiewicz TJ, Harbaugh SV, Yi Y, Maxwell PH, Schneider M, Van Geyte K, Carmeliet P, Revelo MP, Wyder M, Greis KD, Meller J, Czyzyk-Krzeska MF. Mikhaylova O, et al. Among authors: ignacak ml. Mol Cell Biol. 2008 Apr;28(8):2701-17. doi: 10.1128/MCB.01231-07. Epub 2008 Feb 19. Mol Cell Biol. 2008. PMID: 18285459 Free PMC article.
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