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Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function.
Iiri T, Herzmark P, Nakamoto JM, van Dop C, Bourne HR. Iiri T, et al. Nature. 1994 Sep 8;371(6493):164-8. doi: 10.1038/371164a0. Nature. 1994. PMID: 8072545
Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?
Rondard P, Iiri T, Srinivasan S, Meng E, Fujita T, Bourne HR. Rondard P, et al. Among authors: iiri t. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6150-5. doi: 10.1073/pnas.101136198. Epub 2001 May 8. Proc Natl Acad Sci U S A. 2001. PMID: 11344266 Free PMC article.
G proteins propel surprise.
Iiri T, Bourne HR. Iiri T, et al. Nat Genet. 1998 Jan;18(1):8-10. doi: 10.1038/ng0198-8. Nat Genet. 1998. PMID: 9425887 No abstract available.
G-protein diseases furnish a model for the turn-on switch.
Iiri T, Farfel Z, Bourne HR. Iiri T, et al. Nature. 1998 Jul 2;394(6688):35-8. doi: 10.1038/27831. Nature. 1998. PMID: 9665125
Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing hormone secretion in GT1 cells.
Vitalis EA, Costantin JL, Tsai PS, Sakakibara H, Paruthiyil S, Iiri T, Martini JF, Taga M, Choi AL, Charles AC, Weiner RI. Vitalis EA, et al. Among authors: iiri t. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1861-6. doi: 10.1073/pnas.040545197. Proc Natl Acad Sci U S A. 2000. PMID: 10677547 Free PMC article.
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.
Sheikh SP, Vilardarga JP, Baranski TJ, Lichtarge O, Iiri T, Meng EC, Nissenson RA, Bourne HR. Sheikh SP, et al. Among authors: iiri t. J Biol Chem. 1999 Jun 11;274(24):17033-41. doi: 10.1074/jbc.274.24.17033. J Biol Chem. 1999. PMID: 10358054
Galphai is not required for chemotaxis mediated by Gi-coupled receptors.
Neptune ER, Iiri T, Bourne HR. Neptune ER, et al. Among authors: iiri t. J Biol Chem. 1999 Jan 29;274(5):2824-8. doi: 10.1074/jbc.274.5.2824. J Biol Chem. 1999. PMID: 9915816
A Gsalpha mutant designed to inhibit receptor signaling through Gs.
Iiri T, Bell SM, Baranski TJ, Fujita T, Bourne HR. Iiri T, et al. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):499-504. doi: 10.1073/pnas.96.2.499. Proc Natl Acad Sci U S A. 1999. PMID: 9892662 Free PMC article.
Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling.
Apanovitch DM, Iiri T, Karasawa T, Bourne HR, Dohlman HG. Apanovitch DM, et al. Among authors: iiri t. J Biol Chem. 1998 Oct 30;273(44):28597-602. doi: 10.1074/jbc.273.44.28597. J Biol Chem. 1998. PMID: 9786851
Conditional activation defect of a human Gsalpha mutant.
Iiri T, Farfel Z, Bourne HR. Iiri T, et al. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5656-61. doi: 10.1073/pnas.94.11.5656. Proc Natl Acad Sci U S A. 1997. PMID: 9159128 Free PMC article.
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