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LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG. Qile M, et al. Among authors: ijzerman ap. Br J Pharmacol. 2019 Oct;176(19):3871-3885. doi: 10.1111/bph.14798. Epub 2019 Aug 30. Br J Pharmacol. 2019. PMID: 31339551 Free PMC article.
A covalent antagonist for the human adenosine A2A receptor.
Yang X, Dong G, Michiels TJM, Lenselink EB, Heitman L, Louvel J, IJzerman AP. Yang X, et al. Among authors: ijzerman ap. Purinergic Signal. 2017 Jun;13(2):191-201. doi: 10.1007/s11302-016-9549-9. Epub 2016 Dec 3. Purinergic Signal. 2017. PMID: 27915383 Free PMC article.
Medicinal chemistry of adenosine A1 receptor ligands.
Soudijn W, van Wijngaarden I, IJzerman AP. Soudijn W, et al. Among authors: ijzerman ap. Curr Top Med Chem. 2003;3(4):355-67. doi: 10.2174/1568026033392165. Curr Top Med Chem. 2003. PMID: 12570755 Review.
Synthesis and biological evaluation of disubstituted N6-cyclopentyladenine analogues: the search for a neutral antagonist with high affinity for the adenosine A1 receptor.
de Ligt RA, van der Klein PA, von Frijtag Drabbe Künzel JK, Lorenzen A, Ait El Maate F, Fujikawa S, van Westhoven R, van den Hoven T, Brussee J, IJzerman AP. de Ligt RA, et al. Among authors: ijzerman ap. Bioorg Med Chem. 2004 Jan 2;12(1):139-49. doi: 10.1016/j.bmc.2003.10.023. Bioorg Med Chem. 2004. PMID: 14697779
Allosteric modulation of adenosine receptors.
Göblyös A, Ijzerman AP. Göblyös A, et al. Among authors: ijzerman ap. Biochim Biophys Acta. 2011 May;1808(5):1309-18. doi: 10.1016/j.bbamem.2010.06.013. Epub 2010 Jun 27. Biochim Biophys Acta. 2011. PMID: 20599682 Review.
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