Ikeuchi T - Search Results

1

Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.

Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T. Tokutake T, et al. Among authors: ikeuchi t. J Biol Chem. 2012 Oct 12;287(42):35222-35233. doi: 10.1074/jbc.M112.348300. Epub 2012 Aug 21. J Biol Chem. 2012. PMID: 22910909 Free PMC article.

2

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.

Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS. Yu C, et al. Among authors: ikeuchi t. J Biol Chem. 2001 Nov 23;276(47):43756-60. doi: 10.1074/jbc.C100410200. Epub 2001 Oct 2. J Biol Chem. 2001. PMID: 11583985 Free article.

3

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

Ikeuchi T, Dolios G, Kim SH, Wang R, Sisodia SS. Ikeuchi T, et al. J Biol Chem. 2003 Feb 28;278(9):7010-8. doi: 10.1074/jbc.M209252200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12493731 Free article.

4

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.

Ikeuchi T, Sisodia SS. Ikeuchi T, et al. J Biol Chem. 2003 Mar 7;278(10):7751-4. doi: 10.1074/jbc.C200711200. Epub 2003 Jan 24. J Biol Chem. 2003. PMID: 12551931 Free article.

5

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.

Kim SH, Ikeuchi T, Yu C, Sisodia SS. Kim SH, et al. Among authors: ikeuchi t. J Biol Chem. 2003 Sep 5;278(36):33992-4002. doi: 10.1074/jbc.M305834200. Epub 2003 Jun 23. J Biol Chem. 2003. PMID: 12821663 Free article.

6

Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects.

Miida T, Takahashi A, Ikeuchi T. Miida T, et al. Among authors: ikeuchi t. Pharmacol Ther. 2007 Feb;113(2):378-93. doi: 10.1016/j.pharmthera.2006.09.003. Epub 2006 Nov 16. Pharmacol Ther. 2007. PMID: 17113151 Review.

7

Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase.

Kasuga K, Kaneko H, Nishizawa M, Onodera O, Ikeuchi T. Kasuga K, et al. Among authors: ikeuchi t. Biochem Biophys Res Commun. 2007 Aug 17;360(1):90-6. doi: 10.1016/j.bbrc.2007.06.022. Epub 2007 Jun 12. Biochem Biophys Res Commun. 2007. PMID: 17577576

8

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T. Kaneko H, et al. Among authors: ikeuchi t. J Neurosci. 2007 Nov 28;27(48):13092-7. doi: 10.1523/JNEUROSCI.4244-07.2007. J Neurosci. 2007. PMID: 18045903 Free PMC article.

9

Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations.

Ikeuchi T, Kaneko H, Miyashita A, Nozaki H, Kasuga K, Tsukie T, Tsuchiya M, Imamura T, Ishizu H, Aoki K, Ishikawa A, Onodera O, Kuwano R, Nishizawa M. Ikeuchi T, et al. Dement Geriatr Cogn Disord. 2008;26(1):43-9. doi: 10.1159/000141483. Epub 2008 Jun 28. Dement Geriatr Cogn Disord. 2008. PMID: 18587238

10

Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

Hara K, Shiga A, Fukutake T, Nozaki H, Miyashita A, Yokoseki A, Kawata H, Koyama A, Arima K, Takahashi T, Ikeda M, Shiota H, Tamura M, Shimoe Y, Hirayama M, Arisato T, Yanagawa S, Tanaka A, Nakano I, Ikeda S, Yoshida Y, Yamamoto T, Ikeuchi T, Kuwano R, Nishizawa M, Tsuji S, Onodera O. Hara K, et al. Among authors: ikeuchi t. N Engl J Med. 2009 Apr 23;360(17):1729-39. doi: 10.1056/NEJMoa0801560. N Engl J Med. 2009. PMID: 19387015 Free article.

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