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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1822 1
1864 1
1883 1
1885 1
1909 1
1917 1
1920 1
1927 1
1937 1
1943 2
1945 25
1946 30
1947 228
1948 304
1949 274
1950 620
1951 704
1952 868
1953 822
1954 853
1955 822
1956 853
1957 846
1958 722
1959 254
1960 5
1961 3
1962 4
1963 641
1964 1009
1965 847
1966 832
1967 928
1968 981
1969 701
1970 623
1971 522
1972 366
1973 311
1974 338
1975 444
1976 420
1977 431
1978 498
1979 486
1980 545
1981 575
1982 672
1983 816
1984 1094
1985 1496
1986 1850
1987 2553
1988 3971
1989 4658
1990 5185
1991 5638
1992 6171
1993 6946
1994 7585
1995 8062
1996 8647
1997 9185
1998 9776
1999 10537
2000 11808
2001 12453
2002 13347
2003 14426
2004 15807
2005 17503
2006 18401
2007 19593
2008 20353
2009 21185
2010 23064
2011 24741
2012 26575
2013 27956
2014 31205
2015 34434
2016 36098
2017 37837
2018 39838
2019 41467
2020 47961
2021 51820
2022 50106
2023 47304
2024 17317

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735,600 results

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Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Ralpha antibody, is required to broadly inhibit type 2 inflammation.
Le Floc'h A, Allinne J, Nagashima K, Scott G, Birchard D, Asrat S, Bai Y, Lim WK, Martin J, Huang T, Potocky TB, Kim JH, Rafique A, Papadopoulos NJ, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Allergy. 2020 May;75(5):1188-1204. doi: 10.1111/all.14151. Epub 2020 Jan 3. Allergy. 2020. PMID: 31838750 Free PMC article.
Then, in a mouse asthma model by comparing in head-to-head studies, either IL-4 or IL-13 inhibition to dual IL-4/IL-13 inhibition, we demonstrate that blockade of both IL-4 and IL-13 is required to broadly block type 2 inflammation, which …
Then, in a mouse asthma model by comparing in head-to-head studies, either IL-4 or IL-13 inhibition to dual IL-4/IL …
Interleukin-1 (IL-1) pathway.
Weber A, Wasiliew P, Kracht M. Weber A, et al. Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1. Sci Signal. 2010. PMID: 20086235 Review.
The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1-type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1 …
The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in …
The IL-1 family in tumorigenesis and antitumor immunity.
Sun R, Gao DS, Shoush J, Lu B. Sun R, et al. Semin Cancer Biol. 2022 Nov;86(Pt 2):280-295. doi: 10.1016/j.semcancer.2022.05.002. Epub 2022 May 14. Semin Cancer Biol. 2022. PMID: 35580824 Review.
The IL-1 family of cytokines consists of IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, and IL-36gamma. These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL- …
The IL-1 family of cytokines consists of IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL- …
Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic disease.
Cole S, Manghera A, Burns L, Barrett J, Yager N, Rhys H, Skelton A, Cole J, Goodyear CS, Griffiths M, Baeten D, Bertolini M, Shaw S, Al-Mossawi H, Maroof A. Cole S, et al. J Allergy Clin Immunol. 2023 Sep;152(3):783-798. doi: 10.1016/j.jaci.2023.03.035. Epub 2023 May 25. J Allergy Clin Immunol. 2023. PMID: 37244461
Despite sharing 50% sequence homology with IL-17A, the role of IL-17F remains less clear. Clinical findings suggest that dual inhibition of IL-17A and IL-17F in psoriatic disease is more efficacious than IL-17A inhibition alone, positing a patho …
Despite sharing 50% sequence homology with IL-17A, the role of IL-17F remains less clear. Clinical findings suggest that dual …
IL-1 Superfamily Members and Periodontal Diseases.
Papathanasiou E, Conti P, Carinci F, Lauritano D, Theoharides TC. Papathanasiou E, et al. J Dent Res. 2020 Dec;99(13):1425-1434. doi: 10.1177/0022034520945209. Epub 2020 Aug 6. J Dent Res. 2020. PMID: 32758110 Free PMC article. Review.
Over the years, the IL-1 family expanded to include 11 members of cytokines, some with agonist activity (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, and IL-36gamma), receptor antagonists (IL-1Ra, IL …
Over the years, the IL-1 family expanded to include 11 members of cytokines, some with agonist activity (IL-1alpha, IL- …
Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis.
Deng C, Peng N, Tang Y, Yu N, Wang C, Cai X, Zhang L, Hu D, Ciccia F, Lu L. Deng C, et al. Front Immunol. 2021 May 28;12:691559. doi: 10.3389/fimmu.2021.691559. eCollection 2021. Front Immunol. 2021. PMID: 34122457 Free PMC article. Review.
Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. ...IL-25 binds to its receptor composed of IL-17 receptor A (IL-17RA) and IL-17 receptor B (IL-17RB) for signal transduc …
Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. ...IL-25 …
IL-17 Signaling in the Tumor Microenvironment.
Gorczynski RM. Gorczynski RM. Adv Exp Med Biol. 2020;1240:47-58. doi: 10.1007/978-3-030-38315-2_4. Adv Exp Med Biol. 2020. PMID: 32060887 Review.
The IL-17 family itself comprises at least six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F, all of which are known to be secreted as disulfide-linked homo- or heterodimers. These in turn b …
The IL-17 family itself comprises at least six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (al …
IL-1 Family Members in Cancer; Two Sides to Every Story.
Baker KJ, Houston A, Brint E. Baker KJ, et al. Front Immunol. 2019 Jun 7;10:1197. doi: 10.3389/fimmu.2019.01197. eCollection 2019. Front Immunol. 2019. PMID: 31231372 Free PMC article. Review.
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1alpha and IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) as well as two ligands with anti-inflammatory activit …
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1alpha and IL-1bet …
The Role of IL-37 and IL-38 in Obstetrics Abnormalities.
Wang M. Wang M. Front Med (Lausanne). 2021 Aug 27;8:737084. doi: 10.3389/fmed.2021.737084. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34513891 Free PMC article. Review.
Dysregulation of IL-37 and IL-38 has been observed in many auto-immune diseases. IL-37 is substantially reduced in the umbilical cords and placentas of GDM subjects, but IL-37 is significantly induced in the placentas of pre-eclampsia patients, suggest …
Dysregulation of IL-37 and IL-38 has been observed in many auto-immune diseases. IL-37 is substantially reduced in the …
Interleukins and Ischemic Stroke.
Zhu H, Hu S, Li Y, Sun Y, Xiong X, Hu X, Chen J, Qiu S. Zhu H, et al. Front Immunol. 2022 Jan 31;13:828447. doi: 10.3389/fimmu.2022.828447. eCollection 2022. Front Immunol. 2022. PMID: 35173738 Free PMC article. Review.
This overview is aimed to roughly discuss the multiple roles of ILs after ischemic stroke. The roles of IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL-16, IL-17, …
This overview is aimed to roughly discuss the multiple roles of ILs after ischemic stroke. The roles of IL-1, IL-2, IL- …
735,600 results
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