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1963 4
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21 results

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Page 1
Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2.
Zhou W, Fang H, Wu Q, Wang X, Liu R, Li F, Xiao J, Yuan L, Zhou Z, Ma J, Wang L, Zhao W, You H, Ju J, Feng J, Chen C. Zhou W, et al. Int J Biol Sci. 2019 Jun 10;15(8):1723-1732. doi: 10.7150/ijbs.35284. eCollection 2019. Int J Biol Sci. 2019. PMID: 31360114 Free PMC article.
Ilamycin E promotes apoptosis via activation of endoplasmic reticulum (ER) stress, increasing the expression of CHOP, and down-regulating the expression of anti-apoptotic protein Bcl-2. Depletion of CHOP or overexpression of Bcl2 significantly rescued Ilamycin E-ind …
Ilamycin E promotes apoptosis via activation of endoplasmic reticulum (ER) stress, increasing the expression of CHOP, and down-regula …
Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities.
Li J, Liu Z, Hong M, Sun C, Zhang T, Zhang H, Ju J, Ma J. Li J, et al. Front Chem. 2021 Oct 29;9:774555. doi: 10.3389/fchem.2021.774555. eCollection 2021. Front Chem. 2021. PMID: 34778219 Free PMC article.
Our study reveals that four of ilamycin NJLs (1, 6, 8, and 10) have slightly stronger anti-TB activities against Mtb H37Rv (minimum inhibitory concentration, 1.6-1.7 muM) compared with that of ilamycin F on day 14th, but obviously display more potent activities than …
Our study reveals that four of ilamycin NJLs (1, 6, 8, and 10) have slightly stronger anti-TB activities against Mtb H37Rv (minimum i …
Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway.
Xie Q, Yang Z, Huang X, Zhang Z, Li J, Ju J, Zhang H, Ma J. Xie Q, et al. J Hematol Oncol. 2019 Jun 11;12(1):60. doi: 10.1186/s13045-019-0744-3. J Hematol Oncol. 2019. PMID: 31186039 Free PMC article.
However, the cytotoxic activity of Ilamycin C to TNBC cells and a detailed antitumor mechanism have not been reported. METHODS: CCK-8 assays were used to examine cell viability and cytotoxic activity of Ilamycin C to TNBC, non-TNBC MCF7, and nonmalignant MCF10A cell …
However, the cytotoxic activity of Ilamycin C to TNBC cells and a detailed antitumor mechanism have not been reported. METHODS: CCK-8 …
Total Synthesis and Biological Evaluation of Modified Ilamycin Derivatives.
Greve J, Mogk A, Kazmaier U. Greve J, et al. Mar Drugs. 2022 Oct 3;20(10):632. doi: 10.3390/md20100632. Mar Drugs. 2022. PMID: 36286456 Free PMC article.
Derivatives of the ilamycins with a simplified tryptophane unit are synthesized in a straightforward manner. The ilamycin derivative 26 with a cyclic hemiaminal structure is active in the nM-range against several mycobacterial strains and shows no significant cytotoxicity. …
Derivatives of the ilamycins with a simplified tryptophane unit are synthesized in a straightforward manner. The ilamycin derivative …
Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria.
Gao Y, Fang C, Zhou B, Hameed HMA, Sun C, Tian X, He J, Han X, Zhang H, Li J, Ju J, Chen X, Zhong N, Ma J, Xiong X, Zhang T. Gao Y, et al. Commun Biol. 2025 Aug 13;8(1):1219. doi: 10.1038/s42003-025-08646-z. Commun Biol. 2025. PMID: 40804467 Free PMC article.
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identify two novel ilamycin analogs, ilamycin E (ILE) and ilamycin F (ILF), both targeting the ClpC1 component of the ClpC1P1P2 prote …
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identify two n …
Medium optimization and subsequent fermentative regulation enabled the scaled-up production of anti-tuberculosis drug leads ilamycin-E1/E2.
Fan Z, Tong N, Zhuang Z, Ma C, Ma J, Ju J, Duan Y, Zhu X. Fan Z, et al. Biotechnol J. 2022 Apr;17(4):e2100427. doi: 10.1002/biot.202100427. Epub 2022 Feb 10. Biotechnol J. 2022. PMID: 35098690
MAIN METHODS AND MAJOR RESULTS: By applying the statistical Plackett-Burman design (PBD) model, bacterial peptone was first screened out as the only significant but negative factor to affect the ilamycin-E1/E2 production. Subsequent single factor optimization in shaking fl …
MAIN METHODS AND MAJOR RESULTS: By applying the statistical Plackett-Burman design (PBD) model, bacterial peptone was first screened out as …
ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis.
Barter IK, Bedding MJ, Leodolter J, Maxwell JWC, Hawkins PME, Stevens MT, McNeil MB, Jowsey WJ, Wang T, Quan D, Junker S, Flórido M, Hesselson D, Cook GM, Clausen T, Britton WJ, Larance M, Payne RJ. Barter IK, et al. Nat Commun. 2026 Jan 29;17(1):1725. doi: 10.1038/s41467-026-68423-2. Nat Commun. 2026. PMID: 41611701 Free PMC article.
In this study, we combine quantitative proteomics, bioinformatics, transcriptomics, CRISPRi knockdown, and targeted biochemical and biophysical assays to dissect the mechanisms of ecumicin, ilamycin and cyclomarin in clinically relevant Mycobacterium tuberculosis. Striking …
In this study, we combine quantitative proteomics, bioinformatics, transcriptomics, CRISPRi knockdown, and targeted biochemical and biophysi …
Efficient ilamycins production utilizing Enteromorpha prolifera by metabolically engineered Streptomyces atratus.
Jiang YX, Zheng GF, Chen LC, Yang N, Xin XJ, Ma JY, Ju JH, Wu H, Zhao M, Wang R, An FL. Jiang YX, et al. Biotechnol Biofuels Bioprod. 2023 Oct 5;16(1):151. doi: 10.1186/s13068-023-02398-w. Biotechnol Biofuels Bioprod. 2023. PMID: 37798770 Free PMC article.
Furthermore, the production titer of ilamycins and ilamycin E reached 1561.77 mg/L and 745.44 mg/L, respectively, in a 5 L bioreactor. This study suggests that E. prolifera is a promising and eco-friendly nitrogen source for the production of ilamycins....
Furthermore, the production titer of ilamycins and ilamycin E reached 1561.77 mg/L and 745.44 mg/L, respectively, in a 5 L bioreactor …
Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents.
Ma J, Huang H, Xie Y, Liu Z, Zhao J, Zhang C, Jia Y, Zhang Y, Zhang H, Zhang T, Ju J. Ma J, et al. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. Nat Commun. 2017. PMID: 28855504 Free PMC article.
Here, we show the isolation of six anti-mycobacterial ilamycin congeners (1-6) bearing rare L-3-nitro-tyrosine and L-2-amino-4-hexenoic acid structural units from the deep sea-derived Streptomyces atratus SCSIO ZH16. ...Here, the authors show that anti-mycobacterial ila …
Here, we show the isolation of six anti-mycobacterial ilamycin congeners (1-6) bearing rare L-3-nitro-tyrosine and L-2-amino-4-hexeno …
21 results