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Highly purified eicosapentaenoic acid prevents the progression of hepatic steatosis by repressing monounsaturated fatty acid synthesis in high-fat/high-sucrose diet-fed mice.
Kajikawa S, Harada T, Kawashima A, Imada K, Mizuguchi K. Kajikawa S, et al. Prostaglandins Leukot Essent Fatty Acids. 2009 Apr;80(4):229-38. doi: 10.1016/j.plefa.2009.02.004. Epub 2009 Mar 27. Prostaglandins Leukot Essent Fatty Acids. 2009. PMID: 19328666
Eicosapentaenoic Acid Prevents Saturated Fatty Acid-Induced Vascular Endothelial Dysfunction: Involvement of Long-Chain Acyl-CoA Synthetase.
Ishida T, Naoe S, Nakakuki M, Kawano H, Imada K. Ishida T, et al. J Atheroscler Thromb. 2015;22(11):1172-85. doi: 10.5551/jat.28167. Epub 2015 May 27. J Atheroscler Thromb. 2015. PMID: 26016511
Palmitic acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-κB, novel targets of eicosapentaenoic acid.
Kageyama A, Matsui H, Ohta M, Sambuichi K, Kawano H, Notsu T, Imada K, Yokoyama T, Kurabayashi M. Kageyama A, et al. PLoS One. 2013 Jun 28;8(6):e68197. doi: 10.1371/journal.pone.0068197. Print 2013. PLoS One. 2013. PMID: 23840832 Free PMC article.
Eicosapentaenoic acid suppresses palmitate-induced cytokine production by modulating long-chain acyl-CoA synthetase 1 expression in human THP-1 macrophages.
Nakakuki M, Kawano H, Notsu T, Imada K. Nakakuki M, et al. Atherosclerosis. 2013 Apr;227(2):289-96. doi: 10.1016/j.atherosclerosis.2012.12.036. Epub 2013 Feb 4. Atherosclerosis. 2013. PMID: 23433401
Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor.
Ishida T, Ohta M, Nakakuki M, Kami H, Uchiyama R, Kawano H, Notsu T, Imada K, Shimano H. Ishida T, et al. Prostaglandins Leukot Essent Fatty Acids. 2013 Apr;88(4):281-8. doi: 10.1016/j.plefa.2013.01.001. Epub 2013 Jan 30. Prostaglandins Leukot Essent Fatty Acids. 2013. PMID: 23375839
Eicosapentaenoic acid attenuates statin-induced ER stress and toxicity in myoblast.
Ohta M, Kawano H, Notsu T, Naba H, Imada K. Ohta M, et al. Biochem Biophys Res Commun. 2012 Jul 27;424(2):301-7. doi: 10.1016/j.bbrc.2012.06.111. Epub 2012 Jun 27. Biochem Biophys Res Commun. 2012. PMID: 22749998
Eicosapentaenoic acid administration attenuates the pro-inflammatory properties of VLDL by decreasing its susceptibility to lipoprotein lipase in macrophages.
Jinno Y, Nakakuki M, Kawano H, Notsu T, Mizuguchi K, Imada K. Jinno Y, et al. Atherosclerosis. 2011 Dec;219(2):566-72. doi: 10.1016/j.atherosclerosis.2011.09.046. Epub 2011 Oct 4. Atherosclerosis. 2011. PMID: 22018640
Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells.
Mita S, Shimizu Y, Notsu T, Imada K, Kyo S. Mita S, et al. Fertil Steril. 2011 Dec;96(6):1485-1489.e4. doi: 10.1016/j.fertnstert.2011.09.040. Epub 2011 Oct 20. Fertil Steril. 2011. PMID: 22014880
Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet.
Kajikawa S, Imada K, Takeuchi T, Shimizu Y, Kawashima A, Harada T, Mizuguchi K. Kajikawa S, et al. Dig Dis Sci. 2011 Apr;56(4):1065-74. doi: 10.1007/s10620-010-1400-5. Epub 2010 Sep 17. Dig Dis Sci. 2011. PMID: 20848203
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