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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. Vaziri H, et al. Cell. 2001 Oct 19;107(2):149-59. doi: 10.1016/s0092-8674(01)00527-x. Cell. 2001. PMID: 11672523
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity.
Armstrong CM, Kaeberlein M, Imai SI, Guarente L. Armstrong CM, et al. Mol Biol Cell. 2002 Apr;13(4):1427-38. doi: 10.1091/mbc.01-10-0482. Mol Biol Cell. 2002. PMID: 11950950 Free PMC article.
Negative control of p53 by Sir2alpha promotes cell survival under stress.
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Luo J, et al. Cell. 2001 Oct 19;107(2):137-48. doi: 10.1016/s0092-8674(01)00524-4. Cell. 2001. PMID: 11672522
Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging.
Imai S, Johnson FB, Marciniak RA, McVey M, Park PU, Guarente L. Imai S, et al. Cold Spring Harb Symp Quant Biol. 2000;65:297-302. doi: 10.1101/sqb.2000.65.297. Cold Spring Harb Symp Quant Biol. 2000. PMID: 12760043 Review. No abstract available.
The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs.
Ghisays F, Brace CS, Yackly SM, Kwon HJ, Mills KF, Kashentseva E, Dmitriev IP, Curiel DT, Imai SI, Ellenberger T. Ghisays F, et al. Cell Rep. 2015 Mar 17;10(10):1665-1673. doi: 10.1016/j.celrep.2015.02.036. Epub 2015 Mar 12. Cell Rep. 2015. PMID: 25772354 Free PMC article.
NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.
Lin JB, Kubota S, Ban N, Yoshida M, Santeford A, Sene A, Nakamura R, Zapata N, Kubota M, Tsubota K, Yoshino J, Imai SI, Apte RS. Lin JB, et al. Cell Rep. 2016 Sep 27;17(1):69-85. doi: 10.1016/j.celrep.2016.08.073. Cell Rep. 2016. PMID: 27681422 Free PMC article.
A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression.
Grimm AA, Brace CS, Wang T, Stormo GD, Imai S. Grimm AA, et al. Aging Cell. 2011 Apr;10(2):305-17. doi: 10.1111/j.1474-9726.2010.00667.x. Epub 2011 Feb 1. Aging Cell. 2011. PMID: 21176092 Free PMC article.
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Ramsey KM, Mills KF, Satoh A, Imai S. Ramsey KM, et al. Aging Cell. 2008 Jan;7(1):78-88. doi: 10.1111/j.1474-9726.2007.00355.x. Epub 2007 Nov 14. Aging Cell. 2008. PMID: 18005249 Free PMC article.
Is Sirt1 a miracle bullet for longevity?
Imai S. Imai S. Aging Cell. 2007 Dec;6(6):735-7. doi: 10.1111/j.1474-9726.2007.00344.x. Epub 2007 Oct 17. Aging Cell. 2007. PMID: 17941969
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