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Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD.
Sci Rep. 2016 Nov 18;6:36777. doi: 10.1038/srep36777.
Sci Rep. 2016.
PMID: 27857147
Free PMC article.
Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.
Imlay LS, Armstrong CM, Masters MC, Li T, Price KE, Edwards RL, Mann KM, Li LX, Stallings CL, Berry NG, O'Neill PM, Odom AR.
Imlay LS, et al.
ACS Infect Dis. 2015 Apr 10;1(4):157-167. doi: 10.1021/id500047s. Epub 2015 Mar 2.
ACS Infect Dis. 2015.
PMID: 26783558
Free PMC article.
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Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).
Armstrong CM, Meyers DJ, Imlay LS, Freel Meyers C, Odom AR.
Armstrong CM, et al. Among authors: imlay ls.
Antimicrob Agents Chemother. 2015 Sep;59(9):5511-9. doi: 10.1128/AAC.00602-15. Epub 2015 Jun 29.
Antimicrob Agents Chemother. 2015.
PMID: 26124156
Free PMC article.
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Isoprenoid metabolism in apicomplexan parasites.
Imlay L, Odom AR.
Imlay L, et al.
Curr Clin Microbiol Rep. 2014 Dec 1;1(3-4):37-50. doi: 10.1007/s40588-014-0006-7.
Curr Clin Microbiol Rep. 2014.
PMID: 25893156
Free PMC article.
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Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL).
Imlay LS, Lawong AK, Gahalawat S, Kumar A, Xing C, Mittal N, Wittlin S, Churchyard A, Niederstrasser H, Crespo-Fernandez B, Posner BA, Gamo FJ, Baum J, Winzeler EA, Laleu B, Ready JM, Phillips MA.
Imlay LS, et al.
ACS Infect Dis. 2023 Mar 10;9(3):527-539. doi: 10.1021/acsinfecdis.2c00527. Epub 2023 Feb 10.
ACS Infect Dis. 2023.
PMID: 36763526
Free PMC article.
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