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Immune and behavioral consequences of microglial reactivity in the aged brain.
Wynne AM, Henry CJ, Godbout JP. Wynne AM, et al. Integr Comp Biol. 2009 Sep;49(3):254-66. doi: 10.1093/icb/icp009. Epub 2009 Apr 23. Integr Comp Biol. 2009. PMID: 21665818 Free PMC article.
Bidirectional communication between the immune system and the brain is essential for mounting the appropriate immunological, physiological, and behavioral responses to immune activation. ...In support of this notion, peripheral infection in the elderly …
Bidirectional communication between the immune system and the brain is essential for mounting the appropriate immunological, p …
Review: microglia of the aged brain: primed to be activated and resistant to regulation.
Norden DM, Godbout JP. Norden DM, et al. Neuropathol Appl Neurobiol. 2013 Feb;39(1):19-34. doi: 10.1111/j.1365-2990.2012.01306.x. Neuropathol Appl Neurobiol. 2013. PMID: 23039106 Free PMC article. Review.
In this context, microglial activation is amplified and prolonged in the aged brain compared with adults. ...The consequences of impaired regulation and microglial hyper-activation following immune challenge are exaggerated neuroinflammat …
In this context, microglial activation is amplified and prolonged in the aged brain compared with adults. ...The con
Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system.
Dilger RN, Johnson RW. Dilger RN, et al. J Leukoc Biol. 2008 Oct;84(4):932-9. doi: 10.1189/jlb.0208108. J Leukoc Biol. 2008. PMID: 18495785 Free PMC article. Review.
Recent studies suggest that activation of the peripheral immune system elicits a discordant central (i.e., in the brain) inflammatory response in aged but otherwise healthy subjects compared with younger cohorts. A fundamental difference in the reactive
Recent studies suggest that activation of the peripheral immune system elicits a discordant central (i.e., in the brain) infla …
Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice.
Fenn AM, Henry CJ, Huang Y, Dugan A, Godbout JP. Fenn AM, et al. Brain Behav Immun. 2012 Jul;26(5):766-77. doi: 10.1016/j.bbi.2011.10.003. Epub 2011 Oct 17. Brain Behav Immun. 2012. PMID: 22024136 Free PMC article.
In several models of aging, microglia become more inflammatory and reactive to immune challenges. For example, peripheral LPS injection causes exaggerated microglial activation associated with prolonged sickness and depressive-like behavior in aged
In several models of aging, microglia become more inflammatory and reactive to immune challenges. For example, peripheral LPS …