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Year Number of Results
1924 1
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1928 1
1934 1
1935 1
1936 1
1945 5
1946 1
1947 2
1951 1
1952 1
1954 4
1955 5
1956 4
1957 6
1958 4
1959 5
1960 5
1961 8
1962 16
1963 29
1964 56
1965 37
1966 46
1967 40
1968 73
1969 96
1970 96
1971 118
1972 85
1973 102
1974 88
1975 80
1976 52
1977 37
1978 40
1979 41
1980 51
1981 42
1982 41
1983 39
1984 59
1985 62
1986 52
1987 41
1988 52
1989 61
1990 45
1991 49
1992 55
1993 64
1994 68
1995 80
1996 96
1997 99
1998 94
1999 97
2000 134
2001 131
2002 134
2003 122
2004 143
2005 159
2006 178
2007 181
2008 184
2009 194
2010 183
2011 204
2012 232
2013 232
2014 276
2015 272
2016 305
2017 331
2018 348
2019 380
2020 437
2021 512
2022 562
2023 537
2024 650
2025 46

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8,869 results

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Page 1
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ. Hobbs SJ, et al. Nature. 2022 May;605(7910):522-526. doi: 10.1038/s41586-022-04716-y. Epub 2022 Apr 8. Nature. 2022. PMID: 35395152 Free PMC article.
Using a biochemical screen of 57 phages in Escherichia coli and Bacillus subtilis, we discover Acb1 from phage T4 and Apyc1 from phage SBSphiJ as founding members of distinct families of immune evasion proteins. ...Active Acb1 and Apyc1 enzymes are con …
Using a biochemical screen of 57 phages in Escherichia coli and Bacillus subtilis, we discover Acb1 from phage T4 and Apyc1 fr …
Mechanisms and clinical importance of bacteriophage resistance.
Egido JE, Costa AR, Aparicio-Maldonado C, Haas PJ, Brouns SJJ. Egido JE, et al. FEMS Microbiol Rev. 2022 Feb 9;46(1):fuab048. doi: 10.1093/femsre/fuab048. FEMS Microbiol Rev. 2022. PMID: 34558600 Free PMC article. Review.
However, bacteriophage resistance through defense systems and other means could hinder the development of successful phage-based therapies. Here, we review the current state of the field of bacteriophage defense, highlight the relevance of bacteriophage …
However, bacteriophage resistance through defense systems and other means could hinder the development of successful phage-bas …
The Biology of CRISPR-Cas: Backward and Forward.
Hille F, Richter H, Wong SP, Bratovič M, Ressel S, Charpentier E. Hille F, et al. Cell. 2018 Mar 8;172(6):1239-1259. doi: 10.1016/j.cell.2017.11.032. Cell. 2018. PMID: 29522745 Free article. Review.
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRISPR …
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute …
Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy.
Lopatina A, Tal N, Sorek R. Lopatina A, et al. Annu Rev Virol. 2020 Sep 29;7(1):371-384. doi: 10.1146/annurev-virology-011620-040628. Epub 2020 Jun 19. Annu Rev Virol. 2020. PMID: 32559405 Review.
Facing frequent phage challenges, bacteria have evolved numerous mechanisms to resist phage infection. A commonly used phage resistance strategy is abortive infection (Abi), in which the infected cell commits suicide before the phage can complete its r …
Facing frequent phage challenges, bacteria have evolved numerous mechanisms to resist phage infection. A commonly used phag …
Bacteriophage host range and bacterial resistance.
Hyman P, Abedon ST. Hyman P, et al. Adv Appl Microbiol. 2010;70:217-48. doi: 10.1016/S0065-2164(10)70007-1. Epub 2010 Mar 6. Adv Appl Microbiol. 2010. PMID: 20359459 Review.
We consider these adaptations as they occur among bacteriophages (phages) and their bacterial hosts, since they are significant to phage use as antibacterials (phage therapy) or to protection of industrial ferments from phage attack. ...Restrict …
We consider these adaptations as they occur among bacteriophages (phages) and their bacterial hosts, since they are significan …
Mycobacterial phage TM4 requires a eukaryotic-like Ser/Thr protein kinase to silence and escape anti-phage immunity.
Li X, Long X, Chen L, Guo X, Lu L, Hu L, He ZG. Li X, et al. Cell Host Microbe. 2023 Sep 13;31(9):1469-1480.e4. doi: 10.1016/j.chom.2023.07.005. Epub 2023 Aug 10. Cell Host Microbe. 2023. PMID: 37567169 Free article.
Here, we report that a eukaryotic-like StpK7 encoded by MSMEG_1200 in M. smegmatis is required for mycobacteriophage TM4 to escape bacterial defense. stpK7 is located within a gene island, MSMEG_1191-MSMEG_1200, containing multiple anti-phage genes resembling the BREX ( …
Here, we report that a eukaryotic-like StpK7 encoded by MSMEG_1200 in M. smegmatis is required for mycobacteriophage TM4 to escape bacterial …
Bacteriophages inhibit and evade cGAS-like immune function in bacteria.
Huiting E, Cao X, Ren J, Athukoralage JS, Luo Z, Silas S, An N, Carion H, Zhou Y, Fraser JS, Feng Y, Bondy-Denomy J. Huiting E, et al. Cell. 2023 Feb 16;186(4):864-876.e21. doi: 10.1016/j.cell.2022.12.041. Epub 2023 Feb 6. Cell. 2023. PMID: 36750095 Free PMC article.
Whether bacteria harboring CBASS antagonize and co-evolve with phages is unknown. Here, we identified an endogenous cGAS-like enzyme in Pseudomonas aeruginosa that generates 3',3'-cGAMP during phage infection, signals to a phospholipase effector, and limits phage …
Whether bacteria harboring CBASS antagonize and co-evolve with phages is unknown. Here, we identified an endogenous cGAS-like enzyme …
An expanded arsenal of immune systems that protect bacteria from phages.
Millman A, Melamed S, Leavitt A, Doron S, Bernheim A, Hör J, Garb J, Bechon N, Brandis A, Lopatina A, Ofir G, Hochhauser D, Stokar-Avihail A, Tal N, Sharir S, Voichek M, Erez Z, Ferrer JLM, Dar D, Kacen A, Amitai G, Sorek R. Millman A, et al. Cell Host Microbe. 2022 Nov 9;30(11):1556-1569.e5. doi: 10.1016/j.chom.2022.09.017. Epub 2022 Oct 26. Cell Host Microbe. 2022. PMID: 36302390 Free article.
This property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but the full arsenal of anti-phage mechanisms remains unknown. We report the discovery of 21 defense systems that protect bacteria from phag …
This property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but the fu …
Discovery of phage determinants that confer sensitivity to bacterial immune systems.
Stokar-Avihail A, Fedorenko T, Hör J, Garb J, Leavitt A, Millman A, Shulman G, Wojtania N, Melamed S, Amitai G, Sorek R. Stokar-Avihail A, et al. Cell. 2023 Apr 27;186(9):1863-1876.e16. doi: 10.1016/j.cell.2023.02.029. Epub 2023 Apr 7. Cell. 2023. PMID: 37030292 Free article.
To systematically address this question, we isolated 177 phage mutants that escape 15 different defense systems. In many cases, these escaper phages were mutated in the gene sensed by the defense system, enabling us to map the phage determinants that confer s …
To systematically address this question, we isolated 177 phage mutants that escape 15 different defense systems. In many cases, these …
Biotechnological applications of bacteriophages: State of the art.
Harada LK, Silva EC, Campos WF, Del Fiol FS, Vila M, Dąbrowska K, Krylov VN, Balcão VM. Harada LK, et al. Microbiol Res. 2018 Jul-Aug;212-213:38-58. doi: 10.1016/j.micres.2018.04.007. Epub 2018 Apr 30. Microbiol Res. 2018. PMID: 29853167 Free article. Review.
Furthermore, bacteriophage-based vaccination is emerging as one of the most promising preventive strategies. ...Topics covered in detail include the potential of bacteriophage particles in human infections (bacteriophage therapy), nanocages for gene de …
Furthermore, bacteriophage-based vaccination is emerging as one of the most promising preventive strategies. ...Topics covered …
8,869 results