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2001 1
2004 1
2006 2
2007 1
2010 1
2015 1
2018 1
2021 0
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Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.
Holtkamp S, Kreiter S, Selmi A, Simon P, Koslowski M, Huber C, Türeci O, Sahin U. Holtkamp S, et al. Blood. 2006 Dec 15;108(13):4009-17. doi: 10.1182/blood-2006-04-015024. Epub 2006 Aug 29. Blood. 2006. PMID: 16940422 Free article.
However, pharmacokinetic exploration of RNA as a potential drug compound and a key aspect of clinical development is still pending. While investigating the impact of different structural modifications of RNA molecules on the kinetics of the encoded protein in …
However, pharmacokinetic exploration of RNA as a potential drug compound and a key aspect of clinical development is still pending. W …
Immunostimulating capacities of stabilized RNA molecules.
Scheel B, Braedel S, Probst J, Carralot JP, Wagner H, Schild H, Jung G, Rammensee HG, Pascolo S. Scheel B, et al. Eur J Immunol. 2004 Feb;34(2):537-47. doi: 10.1002/eji.200324198. Eur J Immunol. 2004. PMID: 14768059 Free article.
As opposed to CpG DNA, the cis-stabilized RNA is degraded in a few minutes, does not activate B cells and, in contrast to double-stranded RNA, requires MyD88 for activation of the DC. We postulate that phosphorothioate RNA, which mimics trans-stabil
As opposed to CpG DNA, the cis-stabilized RNA is degraded in a few minutes, does not activate B cells and, in contrast to doub …
Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA.
Scheel B, Aulwurm S, Probst J, Stitz L, Hoerr I, Rammensee HG, Weller M, Pascolo S. Scheel B, et al. Eur J Immunol. 2006 Oct;36(10):2807-16. doi: 10.1002/eji.200635910. Eur J Immunol. 2006. PMID: 17013976 Free article.
Stabilized synthetic RNA oligonucleotides (ORN) and protected messenger RNA (mRNA) were recently discovered to possess an immunostimulatory capacity through their recognition by TLR 7 and 8. ...Although they are strong danger signals, RNA are la
Stabilized synthetic RNA oligonucleotides (ORN) and protected messenger RNA (mRNA) were recently discovered to possess
The messenger's great message for vaccination.
Pascolo S. Pascolo S. Expert Rev Vaccines. 2015 Feb;14(2):153-6. doi: 10.1586/14760584.2015.1000871. Expert Rev Vaccines. 2015. PMID: 25586101
Poly ribonucleic acid (RNA) is the only polymer capable to recapitulate all processes of life: containment of genetic information, enzymatic activities and capacity to create defined 3D structures. ...However, the utilization of RNA as a gene vehicle (messeng …
Poly ribonucleic acid (RNA) is the only polymer capable to recapitulate all processes of life: containment of genetic information, en …
Binding of the anticancer alkaloid sanguinarine to double stranded RNAs: insights into the structural and energetics aspects.
Chowdhury SR, Islam MM, Kumar GS. Chowdhury SR, et al. Mol Biosyst. 2010 Jul;6(7):1265-76. doi: 10.1039/b927001a. Epub 2010 May 4. Mol Biosyst. 2010. PMID: 20442937
Elucidation of the molecular aspects of small molecule-RNA complexation is of prime importance for rational RNA targeted drug design strategies. ...These results further advance our understanding on the binding of small molecules that are specific bind …
Elucidation of the molecular aspects of small molecule-RNA complexation is of prime importance for rational RNA targete …
Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumors.
Meeran SM, Katiyar S, Elmets CA, Katiyar SK. Meeran SM, et al. Cancer Res. 2007 Apr 15;67(8):3785-93. doi: 10.1158/0008-5472.CAN-06-3134. Cancer Res. 2007. PMID: 17440092 Free PMC article. Retracted.
IL-12 KO mice and their wild-type (WT) counterparts were subjected to a photocarcinogenesis protocol. When tumor yield was stabilized, samples of tumor and tumor-uninvolved UVB-exposed skin were collected and subjected to immunohistochemistry, gelatinolytic zymography, rea …
IL-12 KO mice and their wild-type (WT) counterparts were subjected to a photocarcinogenesis protocol. When tumor yield was stabilized
Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma.
Ligtenberg MA, Pico de Coaña Y, Shmushkovich T, Yoshimoto Y, Truxova I, Yang Y, Betancur-Boissel M, Eliseev AV, Wolfson AD, Kiessling R. Ligtenberg MA, et al. Mol Ther. 2018 Jun 6;26(6):1482-1493. doi: 10.1016/j.ymthe.2018.04.015. Epub 2018 Apr 13. Mol Ther. 2018. PMID: 29735366 Free PMC article.
In this study, we generated a novel self-delivering small interfering RNA (siRNA) (sdRNA) that knocked down PD-1 expression on healthy donor T cells as well as patient-derived tumor-infiltrating lymphocytes (TIL). We have developed an alternative chemical modification of …
In this study, we generated a novel self-delivering small interfering RNA (siRNA) (sdRNA) that knocked down PD-1 expression on health …
Platelet-derived growth factor stimulates the formation of versican-hyaluronan aggregates and pericellular matrix expansion in arterial smooth muscle cells.
Evanko SP, Johnson PY, Braun KR, Underhill CB, Dudhia J, Wight TN. Evanko SP, et al. Arch Biochem Biophys. 2001 Oct 1;394(1):29-38. doi: 10.1006/abbi.2001.2507. Arch Biochem Biophys. 2001. PMID: 11566024
PDGF is a potent mitogen and chemotactic agent for ASMC and also stimulates the production of extracellular matrix molecules which may regulate the proliferative and migratory capacity of the cells. ...These data suggest that PDGF modulates the synthesis and organiz …
PDGF is a potent mitogen and chemotactic agent for ASMC and also stimulates the production of extracellular matrix molecules which ma …