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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 2
1975 5
1976 3
1977 3
1978 3
1979 1
1980 5
1981 2
1982 2
1983 3
1984 4
1985 11
1986 2
1987 16
1988 11
1989 16
1990 16
1991 17
1992 14
1993 12
1994 24
1995 22
1996 24
1997 24
1998 34
1999 29
2000 54
2001 38
2002 52
2003 53
2004 57
2005 60
2006 81
2007 65
2008 98
2009 81
2010 98
2011 97
2012 95
2013 103
2014 102
2015 87
2016 113
2017 99
2018 111
2019 130
2020 134
2021 121
2022 82
2023 89
2024 13

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2,208 results

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Page 1
Clinical implications of T cell exhaustion for cancer immunotherapy.
Chow A, Perica K, Klebanoff CA, Wolchok JD. Chow A, et al. Nat Rev Clin Oncol. 2022 Dec;19(12):775-790. doi: 10.1038/s41571-022-00689-z. Epub 2022 Oct 10. Nat Rev Clin Oncol. 2022. PMID: 36216928 Review.
T cells are pivotal to the efficacy of current cancer immunotherapies, including immune-checkpoint inhibitors and adoptive cell therapies. However, cancer is associated with T cell exhaustion, a hypofunctional state characterized by progressive loss of T c
T cells are pivotal to the efficacy of current cancer immunotherapies, including immune-checkpoint inhibitors and adoptive cell therapies. H …
The T cell immune response against SARS-CoV-2.
Moss P. Moss P. Nat Immunol. 2022 Feb;23(2):186-193. doi: 10.1038/s41590-021-01122-w. Epub 2022 Feb 1. Nat Immunol. 2022. PMID: 35105982 Review.
The adaptive immune response is a major determinant of the clinical outcome after SARS-CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and correlate with protection but are relatively impaired in severe disease and are associate …
The adaptive immune response is a major determinant of the clinical outcome after SARS-CoV-2 infection and underpins vaccine efficacy. T
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment.
Crespo J, Sun H, Welling TH, Tian Z, Zou W. Crespo J, et al. Curr Opin Immunol. 2013 Apr;25(2):214-21. doi: 10.1016/j.coi.2012.12.003. Epub 2013 Jan 6. Curr Opin Immunol. 2013. PMID: 23298609 Free PMC article. Review.
Many different molecular and cellular mechanisms contribute to the failure of T cells to eradicate the tumor. These include immune suppressive networks that impair ongoing T cell function and enable tumor escape. Recent studies have started to reveal t …
Many different molecular and cellular mechanisms contribute to the failure of T cells to eradicate the tumor. These include immune suppressi …
The effect of stress on the defense systems.
Dragoş D, Tănăsescu MD. Dragoş D, et al. J Med Life. 2010 Jan-Mar;3(1):10-8. J Med Life. 2010. PMID: 20302192 Free PMC article. Review.
The alteration of this mechanism in chronically stressed people impairs the organism's ability to mount a strong immune response with a resultant increase in morbidity. ...There is a substance P, which under stressful circumstances mediates the increase in macrophage cytok …
The alteration of this mechanism in chronically stressed people impairs the organism's ability to mount a strong immune response with …
T Cells in Fibrosis and Fibrotic Diseases.
Zhang M, Zhang S. Zhang M, et al. Front Immunol. 2020 Jun 26;11:1142. doi: 10.3389/fimmu.2020.01142. eCollection 2020. Front Immunol. 2020. PMID: 32676074 Free PMC article. Review.
Based on the divergent expression of surface molecules and cell functions, T cells are subdivided into natural killer T (NKT) cells, gammadelta T cells, CD8(+) cytotoxic T lymphocytes (CTL), regulatory T (Treg) cells, T follicular regulatory (Tfr) cells, and …
Based on the divergent expression of surface molecules and cell functions, T cells are subdivided into natural killer T (NKT) cells, …
Turning cold tumors into hot tumors by improving T-cell infiltration.
Liu YT, Sun ZJ. Liu YT, et al. Theranostics. 2021 Mar 11;11(11):5365-5386. doi: 10.7150/thno.58390. eCollection 2021. Theranostics. 2021. PMID: 33859752 Free PMC article. Review.
ICIs are not effective in "cold tumors", which are characterized by the lack of T-cell infiltration. To realize the full potential of immunotherapy and solve this obstacle, it is essential to understand the drivers of T-cell infiltration into tumors. W …
ICIs are not effective in "cold tumors", which are characterized by the lack of T-cell infiltration. To realize the full poten …
Mechanisms underlying T cell ageing.
Goronzy JJ, Weyand CM. Goronzy JJ, et al. Nat Rev Immunol. 2019 Sep;19(9):573-583. doi: 10.1038/s41577-019-0180-1. Epub 2019 Jun 11. Nat Rev Immunol. 2019. PMID: 31186548 Free PMC article. Review.
T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing the response to vaccination. Easy accessibility to peripheral human T cells as well as an expanding array of tools to examine T cell
T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing th
Autoimmune seizures and epilepsy.
Geis C, Planagumà J, Carreño M, Graus F, Dalmau J. Geis C, et al. J Clin Invest. 2019 Mar 1;129(3):926-940. doi: 10.1172/JCI125178. Epub 2019 Feb 4. J Clin Invest. 2019. PMID: 30714986 Free PMC article. Review.
The risk of epilepsy is higher for disorders in which the antigens are intracellular (often T cell-mediated) compared with disorders in which the antigens are on the cell surface (antibody-mediated). Most autoantibodies against neuronal surface antigens show robust …
The risk of epilepsy is higher for disorders in which the antigens are intracellular (often T cell-mediated) compared with dis …
Approach to primary immunodeficiency.
Devonshire AL, Makhija M. Devonshire AL, et al. Allergy Asthma Proc. 2019 Nov 1;40(6):465-469. doi: 10.2500/aap.2019.40.4273. Allergy Asthma Proc. 2019. PMID: 31690396 Review.
Mycobacterial infections are characteristic of defects in the interleukin (IL) 12/interferon gamma pathway. Screening of newborns for T-cell lymphopenia by using polymerase chain reaction to amplify T-cell receptor excision circles, which are formed wh …
Mycobacterial infections are characteristic of defects in the interleukin (IL) 12/interferon gamma pathway. Screening of newborns for T
An update on the pathophysiology of immune thrombocytopenia.
Semple JW, Rebetz J, Maouia A, Kapur R. Semple JW, et al. Curr Opin Hematol. 2020 Nov;27(6):423-429. doi: 10.1097/MOH.0000000000000612. Curr Opin Hematol. 2020. PMID: 32868673 Review.
PURPOSE OF REVIEW: To summarize the literature relating to the pathophysiology of ITP including the working mechanisms of therapies, T-cell and B-cell physiology, protein/RNA/DNA biochemistry, and animal models in an attempt to unify the perceived abnormal im …
PURPOSE OF REVIEW: To summarize the literature relating to the pathophysiology of ITP including the working mechanisms of therapies, T
2,208 results