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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1925 1
1954 1
1971 1
1974 1
1975 4
1977 1
1978 1
1979 1
1980 4
1981 1
1982 1
1983 1
1984 3
1985 6
1986 4
1987 6
1988 4
1989 6
1990 9
1991 9
1992 7
1993 13
1994 12
1995 5
1996 16
1997 9
1998 17
1999 21
2000 18
2001 16
2002 19
2003 21
2004 27
2005 21
2006 30
2007 22
2008 32
2009 38
2010 38
2011 46
2012 53
2013 63
2014 77
2015 64
2016 67
2017 97
2018 88
2019 129
2020 140
2021 61
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1,183 results
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Page 1
Hyperuricemia is associated with impaired intestinal permeability in mice.
Xu D, Lv Q, Wang X, Cui X, Zhao P, Yang X, Liu X, Yang W, Yang G, Wang G, Wang P, Wang Z, Li Z, Xing S. Xu D, et al. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G484-G492. doi: 10.1152/ajpgi.00151.2019. Epub 2019 Aug 1. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31369290 Free article.
In the present study, we constructed a hyperuricemic mouse model to investigate whether the metabolic disorder caused by hyperuricemia is related to intestinal dysbiosis. A significantly increased intestinal permeability was detected in hyperuricemic mice. .. …
In the present study, we constructed a hyperuricemic mouse model to investigate whether the metabolic disorder caused by hyperuricemia is re …
Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation.
Nicoletti A, Ponziani FR, Biolato M, Valenza V, Marrone G, Sganga G, Gasbarrini A, Miele L, Grieco A. Nicoletti A, et al. World J Gastroenterol. 2019 Sep 7;25(33):4814-4834. doi: 10.3748/wjg.v25.i33.4814. World J Gastroenterol. 2019. PMID: 31543676 Free PMC article. Review.
Increasing evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver damage. In particular, in patients with non-alcoholic fatty liver disease recent hypotheses are considering i …
Increasing evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation …
Impaired intestinal barrier function in a mouse model of hyperuricemia.
Guo Y, Li H, Liu Z, Li C, Chen Y, Jiang C, Yu Y, Tian Z. Guo Y, et al. Mol Med Rep. 2019 Oct;20(4):3292-3300. doi: 10.3892/mmr.2019.10586. Epub 2019 Aug 12. Mol Med Rep. 2019. PMID: 31432190 Free PMC article.
However, it is unclear whether hyperuricemia results in damage to the intestines. The aim of the present study was to investigate intestinal barrier dysfunction in a mouse model of hyperuricemia constructed by knocking out the urate oxidase (Uox) gene. ...Collective …
However, it is unclear whether hyperuricemia results in damage to the intestines. The aim of the present study was to investigate …
Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing.
Chang J, Leong RW, Wasinger VC, Ip M, Yang M, Phan TG. Chang J, et al. Gastroenterology. 2017 Sep;153(3):723-731.e1. doi: 10.1053/j.gastro.2017.05.056. Epub 2017 Jun 8. Gastroenterology. 2017. PMID: 28601482
Mucosal healing was defined as CD Endoscopic Index of Severity of 0 in CD or Mayo endoscopic sub-score of 0-1 for patients with UC. Intestinal permeability was quantified by the Confocal Leak Score (CLS; range: 0=no impaired permeability to 100=complet …
Mucosal healing was defined as CD Endoscopic Index of Severity of 0 in CD or Mayo endoscopic sub-score of 0-1 for patients with UC. Intes …
Gut-liver axis signaling in portal hypertension.
Simbrunner B, Mandorfer M, Trauner M, Reiberger T. Simbrunner B, et al. World J Gastroenterol. 2019 Oct 21;25(39):5897-5917. doi: 10.3748/wjg.v25.i39.5897. World J Gastroenterol. 2019. PMID: 31660028 Free PMC article. Review.
PHT is an important driver of hepatic decompensation such as development of ascites or variceal bleeding. Dysbiosis and an impaired intestinal barrier in ACLD facilitate translocation of bacteria and pathogen-associated molecular patterns (PAMPs) that promote diseas …
PHT is an important driver of hepatic decompensation such as development of ascites or variceal bleeding. Dysbiosis and an impaired …
A20 Restores Impaired Intestinal Permeability and Inhibits Th2 Response in Mice with Colitis.
Chen D, Ma L, Hu T, Liu J, Chen B, Yang P, Liu Z. Chen D, et al. Dig Dis Sci. 2020 May;65(5):1340-1347. doi: 10.1007/s10620-019-05860-8. Epub 2019 Oct 4. Dig Dis Sci. 2020. PMID: 31584137
This study aimed to investigate whether A20 exogenous administration restored impaired intestinal permeability and inhibited T helper (Th)2 response in mice with colitis. ...RESULTS: A20 rectal treatment alleviated DSS-induced chronic colitis and restored …
This study aimed to investigate whether A20 exogenous administration restored impaired intestinal permeability and inhi …
Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease.
Schwiertz A, Spiegel J, Dillmann U, Grundmann D, Bürmann J, Faßbender K, Schäfer KH, Unger MM. Schwiertz A, et al. Parkinsonism Relat Disord. 2018 May;50:104-107. doi: 10.1016/j.parkreldis.2018.02.022. Epub 2018 Feb 12. Parkinsonism Relat Disord. 2018. PMID: 29454662
BACKGROUND/OBJECTIVE: Intestinal inflammation and increased intestinal permeability (both possibly fueled by dysbiosis) have been suggested to be implicated in the multifactorial pathogenesis of Parkinson's disease (PD). The objective of the current st …
BACKGROUND/OBJECTIVE: Intestinal inflammation and increased intestinal permeability (both possibly fueled by dysbiosis) …
Regulation of the intestinal barrier by nutrients: The role of tight junctions.
Suzuki T. Suzuki T. Anim Sci J. 2020 Jan-Dec;91(1):e13357. doi: 10.1111/asj.13357. Anim Sci J. 2020. PMID: 32219956 Free PMC article. Review.
Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal epithelial cells are composed of different junctional molecules, such as claudin and occludin, and regulate the paracellular permeability of water, ions, and macrom …
Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal epithelial cells are composed o …
Protective Effect of Proanthocyanidins in a Rat Model of Mild Intestinal Inflammation and Impaired Intestinal Permeability Induced by LPS.
Gil-Cardoso K, Comitato R, Ginés I, Ardévol A, Pinent M, Virgili F, Terra X, Blay M. Gil-Cardoso K, et al. Mol Nutr Food Res. 2019 Apr;63(8):e1800720. doi: 10.1002/mnfr.201800720. Epub 2019 Jan 23. Mol Nutr Food Res. 2019. PMID: 30656830
Ileal gene expression of permeability/inflammatory genes is analyzed. LPS administration induces intestinal permeability, inflammation, and oxidative stress. ...CONCLUSIONS: Proanthocyanidins, at nutritional and pharmacological doses, prevents endotoxin-induc …
Ileal gene expression of permeability/inflammatory genes is analyzed. LPS administration induces intestinal permeability …
Intestinal Barrier Function in Gluten-Related Disorders.
Cardoso-Silva D, Delbue D, Itzlinger A, Moerkens R, Withoff S, Branchi F, Schumann M. Cardoso-Silva D, et al. Nutrients. 2019 Oct 1;11(10):2325. doi: 10.3390/nu11102325. Nutrients. 2019. PMID: 31581491 Free PMC article. Review.
Instead, recent research has revealed that an innate immune response to a yet-to-be-defined antigen, as well as the gut microbiota, are pivotal in the development in this disorder. Although impairment of the epithelial barrier has been described in all three clinical condi …
Instead, recent research has revealed that an innate immune response to a yet-to-be-defined antigen, as well as the gut microbiota, are pivo …
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