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Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine.
Ramsey LB, Prows CA, Zhang K, Saldaña SN, Sorter MT, Pestian JP, Wenstrup RJ, Vinks AA, Glauser TA. Ramsey LB, et al. Clin Pharmacol Ther. 2019 Jan;105(1):49-52. doi: 10.1002/cpt.1165. Epub 2018 Jul 29. Clin Pharmacol Ther. 2019. PMID: 30058217 Free PMC article. Review. No abstract available.
Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care.
Mizuno T, Dong M, Taylor ZL, Ramsey LB, Vinks AA. Mizuno T, et al. Br J Clin Pharmacol. 2020 Jun 11. doi: 10.1111/bcp.14426. Online ahead of print. Br J Clin Pharmacol. 2020. PMID: 32529759 Review.
Such an approach was pioneered in the late 1970s, but its broad clinical acceptance and implementation have been hampered by the lack of widespread computer technology, including user-friendly software tools. ...Advanced pharmacometrics research is now more appliable and …
Such an approach was pioneered in the late 1970s, but its broad clinical acceptance and implementation have been hampered by the lack …
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.
Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, MacPhee IA. Birdwell KA, et al. Clin Pharmacol Ther. 2015 Jul;98(1):19-24. doi: 10.1002/cpt.113. Epub 2015 Jun 3. Clin Pharmacol Ther. 2015. PMID: 25801146 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC; Clinical Pharmacogenetics Implementation Consortium. Crews KR, et al. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. Clin Pharmacol Ther. 2014. PMID: 24458010 Free PMC article. Review.
We summarize evidence from the literature supporting this association and provide therapeutic recommendations for codeine based on CYP2D6 genotype. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D …
We summarize evidence from the literature supporting this association and provide therapeutic recommendations for codeine based on CYP2D6 ge …
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.
Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T. Lima JJ, et al. Clin Pharmacol Ther. 2020 Aug 8. doi: 10.1002/cpt.2015. Online ahead of print. Clin Pharmacol Ther. 2020. PMID: 32770672
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.
Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez J, Sadhasivam S, Klein TE, Schwab M. Bell GC, et al. Clin Pharmacol Ther. 2017 Aug;102(2):213-218. doi: 10.1002/cpt.598. Epub 2017 Apr 6. Clin Pharmacol Ther. 2017. PMID: 28002639 Free PMC article. Review.
Thoughtful Clinical Use of Pharmacogenetics in Child and Adolescent Psychopharmacology.
Ramsey LB, Namerow LB, Bishop JR, Hicks JK, Bousman C, Croarkin PE, Mathews CA, Van Driest SL, Strawn JR. Ramsey LB, et al. J Am Acad Child Adolesc Psychiatry. 2020 Aug 26:S0890-8567(20)31357-5. doi: 10.1016/j.jaac.2020.08.006. Online ahead of print. J Am Acad Child Adolesc Psychiatry. 2020. PMID: 32860906
AACAP's recent policy statement on Clinical Use of Pharmacogenetic Tests in Prescribing Psychotropic Medications for Children and Adolescents(1) recommends that "clinicians avoid using pharmacogenetic testing to select psychotropic medications in ch …
AACAP's recent policy statement on Clinical Use of Pharmacogenetic Tests in Prescribing Psychotropic Medications for Childr …
Characterizing Pharmacogenetic Testing Among Children's Hospitals.
Brown JT, Ramsey LB, Van Driest SL, Aka I, Colace SI. Brown JT, et al. Clin Transl Sci. 2020 Dec 16. doi: 10.1111/cts.12931. Online ahead of print. Clin Transl Sci. 2020. PMID: 33325650
Large pediatric institutions that routinely use pharmacogenetics in their patient care have published their practices and experiences; however, minimal data exist regarding the full spectrum of pharmacogenetic implementation among children's hos …
Large pediatric institutions that routinely use pharmacogenetics in their patient care have published their practices and experiences …
Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients.
Ramsey LB, Ong HH, Schildcrout JS, Shi Y, Tang LA, Hicks JK, El Rouby N, Cavallari LH, Tuteja S, Aquilante CL, Beitelshees AL, Lemkin DL, Blake KV, Williams H, Cimino JJ, Davis BH, Limdi NA, Empey PE, Horvat CM, Kao DP, Lipori GP, Rosenman MB, Skaar TC, Teal E, Winterstein AG, Owusu Obeng A, Salyakina D, Gupta A, Gruber J, McCafferty-Fernandez J, Bishop JR, Rivers Z, Benner A, Tamraz B, Long-Boyle J, Peterson JF, Van Driest SL; IGNITE Pharmacogenetics Working Group. Ramsey LB, et al. JAMA Netw Open. 2020 Dec 1;3(12):e2029411. doi: 10.1001/jamanetworkopen.2020.29411. JAMA Netw Open. 2020. PMID: 33315113 Free PMC article.
IMPORTANCE: Genotype-guided prescribing in pediatrics could prevent adverse drug reactions and improve therapeutic response. Clinical pharmacogenetic implementation guidelines are available for many medications commonly prescribed to children. ...CONCLUSIONS …
IMPORTANCE: Genotype-guided prescribing in pediatrics could prevent adverse drug reactions and improve therapeutic response. Clinical pha …
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.
Cavallari LH, Van Driest SL, Prows CA, Bishop JR, Limdi NA, Pratt VM, Ramsey LB, Smith DM, Tuteja S, Duong BQ, Hicks JK, Lee JC, Obeng AO, Beitelshees AL, Bell GC, Blake K, Crona DJ, Dressler L, Gregg RA, Hines LJ, Scott SA, Shelton RC, Weitzel KW, Johnson JA, Peterson JF, Empey PE, Skaar TC; IGNITE Network. Cavallari LH, et al. Genet Med. 2019 Oct;21(10):2255-2263. doi: 10.1038/s41436-019-0484-3. Epub 2019 Mar 21. Genet Med. 2019. PMID: 30894703 Free PMC article.
PURPOSE: A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process of implementing CYP2D …
PURPOSE: A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation …
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