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Receptor Switching in Newly Evolved Adeno-associated Viruses.
Havlik LP, Das A, Mietzsch M, Oh DK, Ark J, McKenna R, Agbandje-McKenna M, Asokan A. Havlik LP, et al. J Virol. 2021 Sep 9;95(19):e0058721. doi: 10.1128/JVI.00587-21. Epub 2021 Sep 9. J Virol. 2021. PMID: 34232726 Free PMC article.
Directed evolution has yielded new AAV variants; however, structure-function correlates underlying their improved transduction are generally overlooked. Here, we report that infectious cycling of structurally diverse AAV surface loop libraries yields functionally di …
Directed evolution has yielded new AAV variants; however, structure-function correlates underlying their improved transduction are ge …
Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma.
Thomsen EA, Rovsing AB, Anderson MV, Due H, Huang J, Luo Y, Dybkaer K, Mikkelsen JG. Thomsen EA, et al. Mol Oncol. 2020 Sep;14(9):1978-1997. doi: 10.1002/1878-0261.12753. Epub 2020 Jul 16. Mol Oncol. 2020. PMID: 32585766 Free PMC article.
Diffuse large B-cell lymphoma (DLBCL) is characterized by extensive genetic heterogeneity, and this results in unpredictable responses to the current treatment, R-CHOP, which consists of a cancer drug combination supplemented with the humanized CD20-targeting monocl …
Diffuse large B-cell lymphoma (DLBCL) is characterized by extensive genetic heterogeneity, and this results in unpredictable response …