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Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability.
Morita M, Hayashi T, Ochiai M, Maeda M, Yamaguchi T, Ina K, Kuzuya M. Morita M, et al. Among authors: Ina K. Biochem Biophys Res Commun. 2014 Nov 7;454(1):53-7. doi: 10.1016/j.bbrc.2014.10.029. Epub 2014 Oct 14. Biochem Biophys Res Commun. 2014. PMID: 25445598
Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide.
Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro LJ, Hattori Y. Matsui-Hirai H, et al. Among authors: Ina K. J Pharmacol Exp Ther. 2011 Jun;337(3):591-9. doi: 10.1124/jpet.110.177584. Epub 2011 Feb 28. J Pharmacol Exp Ther. 2011. PMID: 21357660
Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women.
Funami J, Hayashi T, Nomura H, Ding QF, Ishitsuka-Watanabe A, Matsui-Hirai H, Ina K, Zhang J, Yu ZY, Iguchi A. Funami J, et al. Among authors: Ina K. Life Sci. 2009 Aug 12;85(7-8):316-21. doi: 10.1016/j.lfs.2009.06.009. Epub 2009 Jun 26. Life Sci. 2009. PMID: 19560472
Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes.
Hayashi T, Kotani H, Yamaguchi T, Taguchi K, Iida M, Ina K, Maeda M, Kuzuya M, Hattori Y, Ignarro LJ. Hayashi T, et al. Among authors: Ina K. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1168-73. doi: 10.1073/pnas.1322153111. Epub 2014 Jan 7. Proc Natl Acad Sci U S A. 2014. PMID: 24398515 Free PMC article.
Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age.
Hayashi T, Araki A, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Kubota K, Noda M, Noto H, Ina K, Nomura H; Japan CDM group. Hayashi T, et al. Among authors: Ina K. Cardiovasc Diabetol. 2013 Jan 9;12:10. doi: 10.1186/1475-2840-12-10. Cardiovasc Diabetol. 2013. PMID: 23302697 Free PMC article. Clinical Trial.
Age, gender, insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients.
Hayashi T, Kawashima S, Nomura H, Itoh H, Watanabe H, Ohrui T, Yokote K, Sone H, Hattori Y, Yoshizumi M, Ina K, Kubota K; Japan Cholesterol and Diabetes Mellitus Investigation Group. Hayashi T, et al. Among authors: Ina K. Cardiovasc Diabetol. 2011 Oct 6;10:86. doi: 10.1186/1475-2840-10-86. Cardiovasc Diabetol. 2011. PMID: 21978180 Free PMC article. Clinical Trial.
Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals.
Hayashi T, Kubota K, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Araki A, Noda M, Noto H, Sakuma I, Yoshizumi M, Ina K, Nomura H; Japan CDM group. Hayashi T, et al. Among authors: Ina K. Int J Cardiol. 2014 Dec 20;177(3):860-6. doi: 10.1016/j.ijcard.2014.10.093. Epub 2014 Nov 5. Int J Cardiol. 2014. PMID: 25466567
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