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Incidence of second malignancies among patients treated with proton versus photon radiation.
Chung CS, Yock TI, Nelson K, Xu Y, Keating NL, Tarbell NJ. Chung CS, et al. Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):46-52. doi: 10.1016/j.ijrobp.2013.04.030. Epub 2013 Jun 15. Int J Radiat Oncol Biol Phys. 2013. PMID: 23778197
The main outcome measure was the incidence of second malignancies after radiation. RESULTS: We matched 558 proton patients with 558 photon patients from the Surveillance, Epidemiology, and End Results registry. ... …
The main outcome measure was the incidence of second malignancies after radiation. RESULTS: We matched 558 pr …
Predicted rates of secondary malignancies from proton versus photon radiation therapy for stage I seminoma.
Simone CB 2nd, Kramer K, O'Meara WP, Bekelman JE, Belard A, McDonough J, O'Connell J. Simone CB 2nd, et al. Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):242-9. doi: 10.1016/j.ijrobp.2010.11.021. Epub 2011 Jan 13. Int J Radiat Oncol Biol Phys. 2012. PMID: 21236595 Free PMC article.
CONCLUSIONS: For patients with stage I seminoma, proton radiation therapy reduced the predicted secondary cancer risk compared with photon therapy. ...Proton radiation therapy also allowed significant sparing of most …
CONCLUSIONS: For patients with stage I seminoma, proton radiation therapy reduced the predicted secondary cancer …
Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy.
Paganetti H. Paganetti H. Health Phys. 2012 Nov;103(5):652-61. doi: 10.1097/HP.0b013e318261113d. Health Phys. 2012. PMID: 23032895 Free PMC article. Review.
With the average age of radiation therapy patients decreasing and the advent of more complex treatment options comes the concern that the incidences of radiation-induced cancer might increase in the future. ...Furthermore, example calculations a …
With the average age of radiation therapy patients decreasing and the advent of more complex treatment options comes th …
Second primary cancer risks in seminoma patients treated with current and previous radiotherapy protocols: a systematic literature review.
Heemsbergen WD, Spampinato S, Dirkx M, Jahreiß MC, Boormans JL, Franckena M, Boersma LJ. Heemsbergen WD, et al. Radiother Oncol. 2025 Aug;209:110955. doi: 10.1016/j.radonc.2025.110955. Epub 2025 May 24. Radiother Oncol. 2025. PMID: 40419115 Free article.
BACKGROUND AND PURPOSE: Postoperative radiotherapy (RT) with para-aortal (PAO) +/- para-iliac (dog-leg) fields in seminoma patients is an effective treatment, associated with a lifetime risk of developing infra-diaphragmatic radiation-induced second primar …
BACKGROUND AND PURPOSE: Postoperative radiotherapy (RT) with para-aortal (PAO) +/- para-iliac (dog-leg) fields in seminoma patients i …
Long-Term Follow-up of Patients Treated at a Single Institution Using a Passively Scattered Proton Beam; Observations Around the Occurrence of Second Malignancies.
Vernimmen FJ, Fredericks S, Wallace ND, Fitzgerald AP. Vernimmen FJ, et al. Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):680-685. doi: 10.1016/j.ijrobp.2018.10.022. Epub 2018 Oct 27. Int J Radiat Oncol Biol Phys. 2019. PMID: 30612964
PURPOSE: To investigate the occurrence of second malignancies resulting from the secondary radiation from a passively scattered proton beam. ...This setup allows for stereotactic positioning and permits fractionated treatments. The majority of patie …
PURPOSE: To investigate the occurrence of second malignancies resulting from the secondary radiation from a passively s …
Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma.
Taddei PJ, Howell RM, Krishnan S, Scarboro SB, Mirkovic D, Newhauser WD. Taddei PJ, et al. Phys Med Biol. 2010 Dec 7;55(23):7055-65. doi: 10.1088/0031-9155/55/23/S07. Epub 2010 Nov 12. Phys Med Biol. 2010. PMID: 21076199 Free PMC article.
Radiotherapy for HCC is uncommon, largely because of the likelihood of radiation-induced liver disease, an acute side effect that is often fatal. Proton beam therapy (PBT) and intensity-modulated radiation therapy (IMRT) may offer HCC patient …
Radiotherapy for HCC is uncommon, largely because of the likelihood of radiation-induced liver disease, an acute side effect that is …
Subsequent Neoplasm Risk After Modern Mediastinal Radiation Therapy for Pediatric Hodgkin Lymphoma: Insights From a Multi-Institutional Children's Oncology Group Trial.
Milgrom SA, Paganetti H, Dama H, Renfro L, Wu Y, Meyer I, Jeeva M, Parsons SK, Punnett A, Charpentier AM, Lo AC, Vega RM, Keller FG, Kelly KM, Hoppe BS, Castellino SM, Hodgson D. Milgrom SA, et al. Int J Radiat Oncol Biol Phys. 2026 Jul 15;125(4):1121-1129. doi: 10.1016/j.ijrobp.2026.01.026. Epub 2026 Feb 6. Int J Radiat Oncol Biol Phys. 2026. PMID: 41655816 Free PMC article.
PURPOSE: The reported incidence of subsequent malignant neoplasms (SMNs) in long-term survivors of pediatric classic Hodgkin lymphoma (cHL) is based on patients treated with outdated radiation therapy (RT) doses and techniques. ...On aver …
PURPOSE: The reported incidence of subsequent malignant neoplasms (SMNs) in long-term survivors of pediatric classic Hodgkin l …